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    Results: 1 to 20 of 199

    1.

    Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice.

    Mizuno TM, Kelley KA, Pasinetti GM, Roberts JL, Mobbs CV.

    Diabetes. 2003 Nov;52(11):2675-83.PMID: 14578285 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene.

    Kowalski TJ, Liu SM, Leibel RL, Chua SC Jr.

    Diabetes. 2001 Feb;50(2):425-35.PMID: 11272157 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice.

    Makimura H, Mizuno TM, Roberts J, Silverstein J, Beasley J, Mobbs CV.

    Diabetes. 2000 Nov;49(11):1917-23.PMID: 11078460 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes.

    de Luca C, Kowalski TJ, Zhang Y, Elmquist JK, Lee C, Kilimann MW, Ludwig T, Liu SM, Chua SC Jr.

    J Clin Invest. 2005 Dec;115(12):3484-93. Epub 2005 Nov 10.PMID: 16284652 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.

    Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Münzberg H, Hampel B, Alber J, Kloppenburg P, Brüning JC, Wunderlich FT.

    J Neurosci. 2009 Sep 16;29(37):11582-93.PMID: 19759305 [PubMed - indexed for MEDLINE]Related articles

    6.

    Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocortin in diabetic mice independent of changes in leptin or insulin.

    Mizuno TM, Makimura H, Silverstein J, Roberts JL, Lopingco T, Mobbs CV.

    Endocrinology. 1999 Oct;140(10):4551-7.PMID: 10499510 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice.

    Smart JL, Tolle V, Low MJ.

    J Clin Invest. 2006 Feb;116(2):495-505. Epub 2006 Jan 26. Erratum in: J Clin Invest. 2006 Mar;116(3):842. PMID: 16440060 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats.

    Li G, Zhang Y, Wilsey JT, Scarpace PJ.

    Diabetologia. 2005 Nov;48(11):2376-85. Epub 2005 Oct 5.PMID: 16205885 [PubMed - indexed for MEDLINE]Related articles

    9.

    Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).

    Challis BG, Coll AP, Yeo GS, Pinnock SB, Dickson SL, Thresher RR, Dixon J, Zahn D, Rochford JJ, White A, Oliver RL, Millington G, Aparicio SA, Colledge WH, Russ AP, Carlton MB, O'Rahilly S.

    Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4695-700. Epub 2004 Mar 15.PMID: 15070780 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats.

    Li G, Mobbs CV, Scarpace PJ.

    Diabetes. 2003 Aug;52(8):1951-7.PMID: 12882910 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity.

    Makimura H, Mizuno TM, Beasley J, Silverstein JH, Mobbs CV.

    BMC Physiol. 2003 Jun 9;3:4. Epub 2003 Jun 9.PMID: 12795810 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression.

    Makimura H, Mizuno TM, Isoda F, Beasley J, Silverstein JH, Mobbs CV.

    BMC Physiol. 2003 Jul 9;3:5. Epub 2003 Jul 9.PMID: 12848900 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.

    Ren D, Zhou Y, Morris D, Li M, Li Z, Rui L.

    J Clin Invest. 2007 Feb;117(2):397-406. Epub 2007 Jan 18.PMID: 17235396 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    The fatty acid synthase inhibitor cerulenin and feeding, like leptin, activate hypothalamic pro-opiomelanocortin (POMC) neurons.

    Shu IW, Lindenberg DL, Mizuno TM, Roberts JL, Mobbs CV.

    Brain Res. 2003 Sep 19;985(1):1-12.PMID: 12957363 [PubMed - indexed for MEDLINE]Related articles

    15.

    Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice.

    Chua SC Jr, Liu SM, Li Q, Sun A, DeNino WF, Heymsfield SB, Guo XE.

    Am J Physiol Endocrinol Metab. 2004 Mar;286(3):E384-92. Epub 2003 Nov 4.PMID: 14600075 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Independent and additive effects of central POMC and leptin pathways on murine obesity.

    Boston BA, Blaydon KM, Varnerin J, Cone RD.

    Science. 1997 Nov 28;278(5343):1641-4.PMID: 9374468 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting.

    de Souza FS, Santangelo AM, Bumaschny V, Avale ME, Smart JL, Low MJ, Rubinstein M.

    Mol Cell Biol. 2005 Apr;25(8):3076-86.PMID: 15798195 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding.

    Xu AW, Ste-Marie L, Kaelin CB, Barsh GS.

    Endocrinology. 2007 Jan;148(1):72-80. Epub 2006 Oct 5.PMID: 17023536 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    In vivo evidence for inverse agonism of Agouti-related peptide in the central nervous system of proopiomelanocortin-deficient mice.

    Tolle V, Low MJ.

    Diabetes. 2008 Jan;57(1):86-94. Epub 2007 Oct 1.PMID: 17909095 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Ablation of estrogen receptor alpha (ERalpha) prevents upregulation of POMC by leptin and insulin.

    Hirosawa M, Minata M, Harada KH, Hitomi T, Krust A, Koizumi A.

    Biochem Biophys Res Commun. 2008 Jun 27;371(2):320-3. Epub 2008 Apr 24.PMID: 18439911 [PubMed - indexed for MEDLINE]Related articles

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