PubMed

At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation.

Kyriakis JM.

J Biol. 2003;2(4):26. Epub 2003 Oct 22. Review.PMID: 14575531 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase in metabolic control and insulin signaling.

Towler MC, Hardie DG.

Circ Res. 2007 Feb 16;100(3):328-41. Review.PMID: 17307971 [PubMed - indexed for MEDLINE]Related articlesFree article

The AMP-activated protein kinase cascade--a unifying system for energy control.

Carling D.

Trends Biochem Sci. 2004 Jan;29(1):18-24. Review.PMID: 14729328 [PubMed - indexed for MEDLINE]Related articles

Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways.

Han S, Khuri FR, Roman J.

Cancer Res. 2006 Jan 1;66(1):315-23.PMID: 16397245 [PubMed - indexed for MEDLINE]Related articlesFree article

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.

Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35. Epub 2004 Feb 25.PMID: 14985505 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK, the metabolic syndrome and cancer.

Luo Z, Saha AK, Xiang X, Ruderman NB.

Trends Pharmacol Sci. 2005 Feb;26(2):69-76. Review.PMID: 15681023 [PubMed - indexed for MEDLINE]Related articles

AMPK/LKB1 signaling in epithelial cell polarity and cell division.

Brenman JE.

Cell Cycle. 2007 Nov 15;6(22):2755-9. Epub 2007 Aug 22. Review.PMID: 17986859 [PubMed - indexed for MEDLINE]Related articles

Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.

Forcet C, Etienne-Manneville S, Gaude H, Fournier L, Debilly S, Salmi M, Baas A, Olschwang S, Clevers H, Billaud M.

Hum Mol Genet. 2005 May 15;14(10):1283-92. Epub 2005 Mar 30.PMID: 15800014 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.

Xie Z, Dong Y, Zhang M, Cui MZ, Cohen RA, Riek U, Neumann D, Schlattner U, Zou MH.

J Biol Chem. 2006 Mar 10;281(10):6366-75. Epub 2006 Jan 9.PMID: 16407220 [PubMed - indexed for MEDLINE]Related articlesFree article

The LKB1 tumor suppressor negatively regulates mTOR signaling.

Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC.

Cancer Cell. 2004 Jul;6(1):91-9.PMID: 15261145 [PubMed - indexed for MEDLINE]Related articles

LKB1: cancer, polarity, metabolism, and now fertility.

Shaw RJ.

Biochem J. 2008 Nov 15;416(1):e1-3.PMID: 18939946 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenosine monophosphate-activated protein kinase suppresses vascular smooth muscle cell proliferation through the inhibition of cell cycle progression.

Igata M, Motoshima H, Tsuruzoe K, Kojima K, Matsumura T, Kondo T, Taguchi T, Nakamaru K, Yano M, Kukidome D, Matsumoto K, Toyonaga T, Asano T, Nishikawa T, Araki E.

Circ Res. 2005 Oct 14;97(8):837-44. Epub 2005 Sep 8.PMID: 16151020 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.

Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL.

Genes Dev. 2004 Jul 1;18(13):1533-8.PMID: 15231735 [PubMed - indexed for MEDLINE]Related articlesFree article

[From cancer to diabetes treatment : the tumor suppressor LKB1 as a new pharmacological target]

Foretz M, Guigas B, Viollet B.

Med Sci (Paris). 2006 Apr;22(4):348-50. French. No abstract available. PMID: 16597397 [PubMed - indexed for MEDLINE]Related articles

Interference with energy metabolism by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside induces HPV suppression in cervical carcinoma cells and apoptosis in the absence of LKB1.

Nafz J, De-Castro Arce J, Fleig V, Patzelt A, Mazurek S, Rösl F.

Biochem J. 2007 May 1;403(3):501-10.PMID: 17212587 [PubMed - indexed for MEDLINE]Related articlesFree article

LKB1; linking cell structure and tumor suppression.

Hezel AF, Bardeesy N.

Oncogene. 2008 Nov 24;27(55):6908-19. Review.PMID: 19029933 [PubMed - indexed for MEDLINE]Related articles

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

Hardie DG.

Nat Rev Mol Cell Biol. 2007 Oct;8(10):774-85. Review.PMID: 17712357 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase in the heart: role during health and disease.

Arad M, Seidman CE, Seidman JG.

Circ Res. 2007 Mar 2;100(4):474-88. Review.PMID: 17332438 [PubMed - indexed for MEDLINE]Related articlesFree article

Dialogue between LKB1 and AMPK: a hot topic at the cellular pole.

Forcet C, Billaud M.

Sci STKE. 2007 Sep 18;2007(404):pe51. Review.PMID: 17878409 [PubMed - indexed for MEDLINE]Related articles

IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.

Suzuki A, Kusakai G, Kishimoto A, Shimojo Y, Ogura T, Lavin MF, Esumi H.

Biochem Biophys Res Commun. 2004 Nov 19;324(3):986-92.PMID: 15485651 [PubMed - indexed for MEDLINE]Related articles