PubMed

NN414, a SUR1/Kir6.2-selective potassium channel opener, reduces blood glucose and improves glucose tolerance in the VDF Zucker rat.

Carr RD, Brand CL, Bodvarsdottir TB, Hansen JB, Sturis J.

Diabetes. 2003 Oct;52(10):2513-8.PMID: 14514634 [PubMed - indexed for MEDLINE]Related articlesFree article

Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats.

Alemzadeh R, Fledelius C, Bodvarsdottir T, Sturis J.

Metabolism. 2004 Apr;53(4):441-7.PMID: 15045689 [PubMed - indexed for MEDLINE]Related articles

The effects of NN414, a SUR1/Kir6.2 selective potassium channel opener, in healthy male subjects.

Zdravkovic M, Kruse M, Rost KL, Møss J, Kecskes A, Dyrberg T.

J Clin Pharmacol. 2005 Jul;45(7):763-72.PMID: 15951466 [PubMed - indexed for MEDLINE]Related articles

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY.

Diabetes. 2004 Jul;53(7):1706-13.PMID: 15220194 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose.

Ritzel RA, Hansen JB, Veldhuis JD, Butler PC.

J Clin Endocrinol Metab. 2004 Feb;89(2):795-805.PMID: 14764798 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved beta-cell survival and reduced insulitis in a type 1 diabetic rat model after treatment with a beta-cell-selective K(ATP) channel opener.

Skak K, Gotfredsen CF, Lundsgaard D, Hansen JB, Sturis J, Markholst H.

Diabetes. 2004 Apr;53(4):1089-95.PMID: 15047626 [PubMed - indexed for MEDLINE]Related articlesFree article

The effects of NN414, a SUR1/Kir6.2 selective potassium channel opener in subjects with type 2 diabetes.

Zdravkovic M, Kruse M, Rost KL, Møss J, Kecskes A.

Exp Clin Endocrinol Diabetes. 2007 Jun;115(6):405-6.PMID: 17701889 [PubMed - indexed for MEDLINE]Related articles

Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats.

Lynn FC, Pamir N, Ng EH, McIntosh CH, Kieffer TJ, Pederson RA.

Diabetes. 2001 May;50(5):1004-11.PMID: 11334402 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats.

Pospisilik JA, Stafford SG, Demuth HU, Brownsey R, Parkhouse W, Finegood DT, McIntosh CH, Pederson RA.

Diabetes. 2002 Apr;51(4):943-50.PMID: 11916911 [PubMed - indexed for MEDLINE]Related articlesFree article

Amplified hormonal counterregulatory responses to hypoglycemia in rats after systemic delivery of a SUR-1-selective K(+) channel opener?

Fan X, Ding Y, Cheng H, Gram DX, Sherwin RS, McCrimmon RJ.

Diabetes. 2008 Dec;57(12):3327-34. Epub 2008 Sep 5.PMID: 18776135 [PubMed - indexed for MEDLINE]Related articlesFree article

Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues.

Dabrowski M, Larsen T, Ashcroft FM, Bondo Hansen J, Wahl P.

Diabetologia. 2003 Oct;46(10):1375-82. Epub 2003 Sep 5.PMID: 12961066 [PubMed - indexed for MEDLINE]Related articles

New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells.

Nielsen FE, Ebdrup S, Jensen AF, Ynddal L, Bodvarsdottir TB, Stidsen C, Worsaae A, Boonen HC, Arkhammar PO, Fremming T, Wahl P, Kornø HT, Hansen JB.

J Med Chem. 2006 Jul 13;49(14):4127-39.PMID: 16821773 [PubMed - indexed for MEDLINE]Related articles

Lisofylline, a novel anti-inflammatory agent, enhances glucose-stimulated insulin secretion in vivo and in vitro: studies in prediabetic and normal rats.

Striffler JS, Nadler JL.

Metabolism. 2004 Mar;53(3):290-6.PMID: 15015139 [PubMed - indexed for MEDLINE]Related articles

Openers of ATP-dependent K+-channels protect against a signal-transduction-linked and not freely reversible defect of insulin secretion in a rat islet transplantation model of Type 2 diabetes.

Björklund A, Bondo Hansen J, Falkmer S, Grill V.

Diabetologia. 2004 May;47(5):885-91. Epub 2004 Apr 16.PMID: 15088085 [PubMed - indexed for MEDLINE]Related articles

Comparison of beta-cell function after long-term treatment with either insulin, insulin plus gliclazide or gliclazide in neonatal streptozotocin-induced non-insulin-dependent diabetic rats.

Kawai K, Suzuki S, Murayama Y, Watanabe Y, Yamashita K.

Diabetes Res Clin Pract. 1991 Jul;12(3):163-72.PMID: 1832376 [PubMed - indexed for MEDLINE]Related articles

Differences in plasma homocysteine levels between Zucker fatty and Zucker diabetic fatty rats following 3 weeks oral administration of organic vanadium compounds.

Wasan KM, Risovic V, Yuen VG, McNeill JH.

J Trace Elem Med Biol. 2006;19(4):251-8. Epub 2005 Dec 13.PMID: 16443173 [PubMed - indexed for MEDLINE]Related articles

Metabolic and hemodynamic effects of moxonidine in the Zucker diabetic fatty rat model of type 2 diabetes.

Yakubu-Madus FE, Johnson WT, Zimmerman KM, Dananberg J, Steinberg MI.

Diabetes. 1999 May;48(5):1093-100.PMID: 10331415 [PubMed - indexed for MEDLINE]Related articlesFree article

Attenuation of type 2 diabetes mellitus in the male Zucker diabetic fatty rat: the effects of stress and non-volitional exercise.

Király MA, Bates HE, Yue JT, Goche-Montes D, Fediuc S, Park E, Matthews SG, Vranic M, Riddell MC.

Metabolism. 2007 Jun;56(6):732-44.PMID: 17512304 [PubMed - indexed for MEDLINE]Related articles

Sensory nerve inactivation by resiniferatoxin improves insulin sensitivity in male obese Zucker rats.

Moesgaard SG, Brand CL, Sturis J, Ahrén B, Wilken M, Fleckner J, Carr RD, Svendsen O, Hansen AJ, Gram DX.

Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1137-45.PMID: 15883192 [PubMed - indexed for MEDLINE]Related articlesFree article

Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives.

Hansen JB.

Curr Med Chem. 2006;13(4):361-76. Review.PMID: 16475928 [PubMed - indexed for MEDLINE]Related articles