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    Results: 1 to 20 of 261

    1.

    Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance.

    Haluzik M, Yakar S, Gavrilova O, Setser J, Boisclair Y, LeRoith D.

    Diabetes. 2003 Oct;52(10):2483-9.PMID: 14514630 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity.

    Yakar S, Liu JL, Fernandez AM, Wu Y, Schally AV, Frystyk J, Chernausek SD, Mejia W, Le Roith D.

    Diabetes. 2001 May;50(5):1110-8.PMID: 11334415 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice.

    Yakar S, Setser J, Zhao H, Stannard B, Haluzik M, Glatt V, Bouxsein ML, Kopchick JJ, LeRoith D.

    J Clin Invest. 2004 Jan;113(1):96-105.PMID: 14702113 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    A transgenic model to determine the physiological role of liver-derived insulin-like growth factor I.

    Sjögren K, Jansson JO, Isaksson OG, Ohlsson C.

    Minerva Endocrinol. 2002 Dec;27(4):299-311. Review.PMID: 12511852 [PubMed - indexed for MEDLINE]Related articles

    5.

    Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression.

    Anzo M, Cobb LJ, Hwang DL, Mehta H, Said JW, Yakar S, LeRoith D, Cohen P.

    Cancer Res. 2008 May 1;68(9):3342-9.PMID: 18451161 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Age-dependent onset of liver-specific IGF-I gene deficiency and its persistence in old age: implications for postnatal growth and insulin resistance in LID mice.

    Tang Z, Yu R, Lu Y, Parlow AF, Liu JL.

    Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E288-95. Epub 2005 Mar 15.PMID: 15769793 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiency.

    Liao L, Dearth RK, Zhou S, Britton OL, Lee AV, Xu J.

    Endocrinology. 2006 Aug;147(8):3877-88. Epub 2006 May 18.PMID: 16709615 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone.

    Yakar S, Bouxsein ML, Canalis E, Sun H, Glatt V, Gundberg C, Cohen P, Hwang D, Boisclair Y, Leroith D, Rosen CJ.

    J Endocrinol. 2006 May;189(2):289-99.PMID: 16648296 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    A model for tissue-specific inducible insulin-like growth factor-I (IGF-I) inactivation to determine the physiological role of liver-derived IGF-I.

    Sjögren K, Jansson JO, Isaksson OG, Ohlsson C.

    Endocrine. 2002 Dec;19(3):249-56. Review.PMID: 12624424 [PubMed - indexed for MEDLINE]Related articles

    10.

    Circulating levels of IGF-1 directly regulate bone growth and density.

    Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, Ooi GT, Setser J, Frystyk J, Boisclair YR, LeRoith D.

    J Clin Invest. 2002 Sep;110(6):771-81.PMID: 12235108 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Role of growth hormone (GH) in liver regeneration.

    Pennisi PA, Kopchick JJ, Thorgeirsson S, LeRoith D, Yakar S.

    Endocrinology. 2004 Oct;145(10):4748-55. Epub 2004 Jul 8.PMID: 15242989 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    The growth hormone-insulin like growth factor axis revisited: lessons from IGF-1 and IGF-1 receptor gene targeting.

    Yakar S, Kim H, Zhao H, Toyoshima Y, Pennisi P, Gavrilova O, Leroith D.

    Pediatr Nephrol. 2005 Mar;20(3):251-4. Epub 2005 Jan 12. Review.PMID: 15645308 [PubMed - indexed for MEDLINE]Related articles

    13.

    Protein calorie restriction affects nonhepatic IGF-I production and the lymphoid system: studies using the liver-specific IGF-I gene-deleted mouse model.

    Naranjo WM, Yakar S, Sanchez-Gomez M, Perez AU, Setser J, LERoith D.

    Endocrinology. 2002 Jun;143(6):2233-41.PMID: 12021187 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Administration of human insulin-like growth factor-binding protein-1 increases circulating levels of growth hormone in mice.

    Cingel-Ristic V, Van Neck JW, Frystyk J, Drop SL, Flyvbjerg A.

    Endocrinology. 2004 Sep;145(9):4401-7. Epub 2004 May 27.PMID: 15166120 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Studies involving the GH-IGF axis: Lessons from IGF-I and IGF-I receptor gene targeting mouse models.

    Yakar S, Pennisi P, Kim CH, Zhao H, Toyoshima Y, Gavrilova O, LeRoith D.

    J Endocrinol Invest. 2005;28(5 Suppl):19-22. Review.PMID: 16114270 [PubMed - indexed for MEDLINE]Related articles

    16.

    Tissue-specific alterations in insulin-like growth factor-I concentrations in response to 3,3',5-triiodo-L-thyronine supplementation in the growth hormone receptor-deficient sex-linked dwarf chicken.

    Vasilatos-Younken R, Dunnington EA, Siegel PB, McMurtry JP.

    Gen Comp Endocrinol. 1997 Jan;105(1):31-9.PMID: 9000465 [PubMed - indexed for MEDLINE]Related articles

    17.

    Fat storage capacity in growth-selected and control mouse lines is associated with line-specific gene expression and plasma hormone levels.

    Timtchenko D, Kratzsch J, Sauerwein H, Wegner J, Souffrant WB, Schwerin M, Brockmann GA.

    Int J Obes Relat Metab Disord. 1999 Jun;23(6):586-94.PMID: 10411231 [PubMed - indexed for MEDLINE]Related articles

    18.

    Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus.

    Pennisi P, Gavrilova O, Setser-Portas J, Jou W, Santopietro S, Clemmons D, Yakar S, LeRoith D.

    Endocrinology. 2006 Jun;147(6):2619-30. Epub 2006 Mar 2.PMID: 16513827 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism.

    Fan Y, Menon RK, Cohen P, Hwang D, Clemens T, DiGirolamo DJ, Kopchick JJ, Le Roith D, Trucco M, Sperling MA.

    J Biol Chem. 2009 Jul 24;284(30):19937-44. Epub 2009 May 21.PMID: 19460757 [PubMed - indexed for MEDLINE]Related articles

    20.

    Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects.

    Rico-Bautista E, Greenhalgh CJ, Tollet-Egnell P, Hilton DJ, Alexander WS, Norstedt G, Flores-Morales A.

    Mol Endocrinol. 2005 Mar;19(3):781-93. Epub 2004 Nov 24.PMID: 15563548 [PubMed - indexed for MEDLINE]Related articlesFree article

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