PubMed

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.

Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG.

J Biol. 2003;2(4):28. Epub 2003 Sep 24.PMID: 14511394 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of 3-phosphoglycerate and other metabolites on the activation of AMP-activated protein kinase by LKB1-STRAD-MO25.

Ellingson WJ, Chesser DG, Winder WW.

Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E400-7. Epub 2006 Sep 19.PMID: 16985256 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25.

Taylor EB, Ellingson WJ, Lamb JD, Chesser DG, Winder WW.

Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1055-61. Epub 2005 Jan 11.PMID: 15644453 [PubMed - indexed for MEDLINE]Related articlesFree article

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR.

EMBO J. 2004 Feb 25;23(4):833-43. Epub 2004 Feb 19.PMID: 14976552 [PubMed - indexed for MEDLINE]Related articlesFree article

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.

Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35. Epub 2004 Feb 25.PMID: 14985505 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of the LKB1-STRAD-MO25 complex.

Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR.

J Cell Sci. 2004 Dec 15;117(Pt 26):6365-75. Epub 2004 Nov 23.PMID: 15561763 [PubMed - indexed for MEDLINE]Related articlesFree article

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation.

Jaleel M, Villa F, Deak M, Toth R, Prescott AR, Van Aalten DM, Alessi DR.

Biochem J. 2006 Mar 15;394(Pt 3):545-55.PMID: 16396636 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the AMP-activated protein kinase pathway in chickens.

Proszkowiec-Weglarz M, Richards MP, Ramachandran R, McMurtry JP.

Comp Biochem Physiol B Biochem Mol Biol. 2006 Jan;143(1):92-106. Epub 2005 Dec 15.PMID: 16343965 [PubMed - indexed for MEDLINE]Related articles

Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle.

Branvold DJ, Allred DR, Beckstead DJ, Kim HJ, Fillmore N, Condon BM, Brown JD, Sudweeks SN, Thomson DM, Winder WW.

J Appl Physiol. 2008 Oct;105(4):1218-27. Epub 2008 Jul 31.PMID: 18669938 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence against regulation of AMP-activated protein kinase and LKB1/STRAD/MO25 activity by creatine phosphate.

Taylor EB, Ellingson WJ, Lamb JD, Chesser DG, Compton CL, Winder WW.

Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E661-9. Epub 2005 Nov 8.PMID: 16278246 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of LKB1/STRAD localization and function by E-cadherin.

Sebbagh M, Santoni MJ, Hall B, Borg JP, Schwartz MA.

Curr Biol. 2009 Jan 13;19(1):37-42. Epub 2008 Dec 24.PMID: 19110428 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate.

Jaleel M, McBride A, Lizcano JM, Deak M, Toth R, Morrice NA, Alessi DR.

FEBS Lett. 2005 Feb 28;579(6):1417-23.PMID: 15733851 [PubMed - indexed for MEDLINE]Related articles

IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.

Suzuki A, Kusakai G, Kishimoto A, Shimojo Y, Ogura T, Lavin MF, Esumi H.

Biochem Biophys Res Commun. 2004 Nov 19;324(3):986-92.PMID: 15485651 [PubMed - indexed for MEDLINE]Related articles

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.

Sakamoto K, Göransson O, Hardie DG, Alessi DR.

Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E310-7. Epub 2004 Apr 6.PMID: 15068958 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.

Xie Z, Dong Y, Zhang M, Cui MZ, Cohen RA, Riek U, Neumann D, Schlattner U, Zou MH.

J Biol Chem. 2006 Mar 10;281(10):6366-75. Epub 2006 Jan 9.PMID: 16407220 [PubMed - indexed for MEDLINE]Related articlesFree article

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade.

Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LG, Neumann D, Schlattner U, Wallimann T, Carlson M, Carling D.

Curr Biol. 2003 Nov 11;13(22):2004-8.PMID: 14614828 [PubMed - indexed for MEDLINE]Related articles

AMPK activation by long chain fatty acyl analogs.

Za'tara G, Bar-Tana J, Kalderon B, Suter M, Morad E, Samovski D, Neumann D, Hertz R.

Biochem Pharmacol. 2008 Nov 15;76(10):1263-75. Epub 2008 Sep 3.PMID: 18812171 [PubMed - indexed for MEDLINE]Related articles

C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.

Fogarty S, Hardie DG.

J Biol Chem. 2009 Jan 2;284(1):77-84. Epub 2008 Oct 14.PMID: 18854318 [PubMed - indexed for MEDLINE]Related articlesFree article

LKB1-dependent signaling pathways.

Alessi DR, Sakamoto K, Bayascas JR.

Annu Rev Biochem. 2006;75:137-63. Review.PMID: 16756488 [PubMed - indexed for MEDLINE]Related articles

AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner.

Sun Y, Connors KE, Yang DQ.

Mol Cell Biochem. 2007 Dec;306(1-2):239-45. Epub 2007 Sep 5.PMID: 17786544 [PubMed - indexed for MEDLINE]Related articles