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    Results: 1 to 20 of 121

    1.

    Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations.

    Gloyn AL, Noordam K, Willemsen MA, Ellard S, Lam WW, Campbell IW, Midgley P, Shiota C, Buettger C, Magnuson MA, Matschinsky FM, Hattersley AT.

    Diabetes. 2003 Sep;52(9):2433-40.PMID: 12941786 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.

    Gloyn AL, Odili S, Zelent D, Buettger C, Castleden HA, Steele AM, Stride A, Shiota C, Magnuson MA, Lorini R, d'Annunzio G, Stanley CA, Kwagh J, van Schaftingen E, Veiga-da-Cunha M, Barbetti F, Dunten P, Han Y, Grimsby J, Taub R, Ellard S, Hattersley AT, Matschinsky FM.

    J Biol Chem. 2005 Apr 8;280(14):14105-13. Epub 2005 Jan 25.PMID: 15677479 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation.

    Cuesta-Muñoz AL, Huopio H, Otonkoski T, Gomez-Zumaquero JM, Näntö-Salonen K, Rahier J, López-Enriquez S, García-Gimeno MA, Sanz P, Soriguer FC, Laakso M.

    Diabetes. 2004 Aug;53(8):2164-8.PMID: 15277402 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Activating glucokinase (GCK) mutations as a cause of medically responsive congenital hyperinsulinism: prevalence in children and characterisation of a novel GCK mutation.

    Christesen HB, Tribble ND, Molven A, Siddiqui J, Sandal T, Brusgaard K, Ellard S, Njølstad PR, Alm J, Brock Jacobsen B, Hussain K, Gloyn AL.

    Eur J Endocrinol. 2008 Jul;159(1):27-34. Epub 2008 May 1.PMID: 18450771 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy.

    Gloyn AL.

    Hum Mutat. 2003 Nov;22(5):353-62. Review.PMID: 14517946 [PubMed - indexed for MEDLINE]Related articles

    6.

    Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis.

    Davis EA, Cuesta-Muñoz A, Raoul M, Buettger C, Sweet I, Moates M, Magnuson MA, Matschinsky FM.

    Diabetologia. 1999 Oct;42(10):1175-86.PMID: 10525657 [PubMed - indexed for MEDLINE]Related articles

    7.

    Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations.

    Sayed S, Langdon DR, Odili S, Chen P, Buettger C, Schiffman AB, Suchi M, Taub R, Grimsby J, Matschinsky FM, Stanley CA.

    Diabetes. 2009 Jun;58(6):1419-27. Epub 2009 Mar 31.PMID: 19336674 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Functional analysis of human glucokinase gene mutations causing MODY2: exploring the regulatory mechanisms of glucokinase activity.

    García-Herrero CM, Galán M, Vincent O, Flández B, Gargallo M, Delgado-Alvarez E, Blázquez E, Navas MA.

    Diabetologia. 2007 Feb;50(2):325-33. Epub 2006 Dec 21.PMID: 17186219 [PubMed - indexed for MEDLINE]Related articles

    9.

    Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations.

    Heredia VV, Carlson TJ, Garcia E, Sun S.

    J Biol Chem. 2006 Dec 29;281(52):40201-7. Epub 2006 Nov 2.PMID: 17082186 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Heterogeneity in disease severity in a family with a novel G68V GCK activating mutation causing persistent hyperinsulinaemic hypoglycaemia of infancy.

    Wabitsch M, Lahr G, Van de Bunt M, Marchant C, Lindner M, von Puttkamer J, Fenneberg A, Debatin KM, Klein R, Ellard S, Clark A, Gloyn AL.

    Diabet Med. 2007 Dec;24(12):1393-9. Epub 2007 Nov 1.PMID: 17976205 [PubMed - indexed for MEDLINE]Related articles

    11.

    Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability.

    Galán M, Vincent O, Roncero I, Azriel S, Boix-Pallares P, Delgado-Alvarez E, Díaz-Cadórniga F, Blázquez E, Navas MA.

    Biochem J. 2006 Jan 1;393(Pt 1):389-96.PMID: 16173921 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy.

    Christesen HB, Jacobsen BB, Odili S, Buettger C, Cuesta-Munoz A, Hansen T, Brusgaard K, Massa O, Magnuson MA, Shiota C, Matschinsky FM, Barbetti F.

    Diabetes. 2002 Apr;51(4):1240-6.PMID: 11916951 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene.

    Barbetti F, Cobo-Vuilleumier N, Dionisi-Vici C, Toni S, Ciampalini P, Massa O, Rodriguez-Bada P, Colombo C, Lenzi L, Garcia-Gimeno MA, Bermudez-Silva FJ, Rodriguez de Fonseca F, Banin P, Aledo JC, Baixeras E, Sanz P, Cuesta-Muñoz AL.

    Mol Endocrinol. 2009 Dec;23(12):1983-9. Epub 2009 Nov 2.PMID: 19884385 [PubMed - in process]Related articles

    14.

    From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation.

    Sagen JV, Odili S, Bjørkhaug L, Zelent D, Buettger C, Kwagh J, Stanley C, Dahl-Jørgensen K, de Beaufort C, Bell GI, Han Y, Grimsby J, Taub R, Molven A, Søvik O, Njølstad PR, Matschinsky FM.

    Diabetes. 2006 Jun;55(6):1713-22.PMID: 16731834 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.

    Osbak KK, Colclough K, Saint-Martin C, Beer NL, Bellanné-Chantelot C, Ellard S, Gloyn AL.

    Hum Mutat. 2009 Nov;30(11):1512-26.PMID: 19790256 [PubMed - in process]Related articles

    16.

    Glucokinase gene mutations: structural and genotype-phenotype analyses in MODY children from South Italy.

    Tinto N, Zagari A, Capuano M, De Simone A, Capobianco V, Daniele G, Giugliano M, Spadaro R, Franzese A, Sacchetti L.

    PLoS One. 2008 Apr 2;3(4):e1870.PMID: 18382660 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Regulation of pancreatic beta-cell glucokinase: from basics to therapeutics.

    Matschinsky FM.

    Diabetes. 2002 Dec;51 Suppl 3:S394-404. Review.PMID: 12475782 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations.

    Byrne MM, Sturis J, Clément K, Vionnet N, Pueyo ME, Stoffel M, Takeda J, Passa P, Cohen D, Bell GI, et al.

    J Clin Invest. 1994 Mar;93(3):1120-30.PMID: 8132752 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Adaptation of glucokinase gene expression in the rat dorsal vagal complex in a model for recurrent intermediate insulin-induced hypoglycemia: impact of gender.

    Genabai NK, Vavaiya KV, Briski KP.

    J Mol Neurosci. 2009 Jan;37(1):80-5. Epub 2008 Jul 9.PMID: 18612599 [PubMed - indexed for MEDLINE]Related articles

    20.

    Glucokinase (GCK) and other susceptibility genes for beta-cell dysfunction: the candidate approach.

    Gloyn AL, Tribble ND, van de Bunt M, Barrett A, Johnson PR.

    Biochem Soc Trans. 2008 Jun;36(Pt 3):306-11.PMID: 18481947 [PubMed - indexed for MEDLINE]Related articles

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