PubMed

An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures.

Bennett RG, Hamel FG, Duckworth WC.

Diabetes. 2003 Sep;52(9):2315-20.PMID: 12941771 [PubMed - indexed for MEDLINE]Related articlesFree article

Degradation of amylin by insulin-degrading enzyme.

Bennett RG, Duckworth WC, Hamel FG.

J Biol Chem. 2000 Nov 24;275(47):36621-5.PMID: 10973971 [PubMed - indexed for MEDLINE]Related articlesFree article

The effects of amylin on insulin secretion from Rin m5F cells and glycogen synthesis and lipogenesis in rat primary cultured hepatocytes.

Suzuki S, Murakami M, Abe S, Satoh Y, Shintani S, Ishizuka J, Suzuki K, Thompson JC, Toyota T.

Diabetes Res Clin Pract. 1992 Jan;15(1):77-84.PMID: 1311671 [PubMed - indexed for MEDLINE]Related articles

Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid.

Aitken JF, Loomes KM, Konarkowska B, Cooper GJ.

Biochem J. 2003 Sep 15;374(Pt 3):779-84.PMID: 12812521 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin inhibition of the proteasome is dependent on degradation of insulin by insulin-degrading enzyme.

Bennett RG, Fawcett J, Kruer MC, Duckworth WC, Hamel FG.

J Endocrinol. 2003 Jun;177(3):399-405.PMID: 12773120 [PubMed - indexed for MEDLINE]Related articlesFree article

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.

Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ.

J Neurosci. 2000 Mar 1;20(5):1657-65.PMID: 10684867 [PubMed - indexed for MEDLINE]Related articlesFree article

[Kinetic studies of insulin degrading enzyme in cultured human lymphocytes]

Yaso S.

Nippon Naibunpi Gakkai Zasshi. 1988 Apr 20;64(4):289-302. Japanese. PMID: 3042472 [PubMed - indexed for MEDLINE]Related articles

Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures.

Lynch JA, George AM, Eisenhauer PB, Conn K, Gao W, Carreras I, Wells JM, McKee A, Ullman MD, Fine RE.

J Neurosci Res. 2006 May 15;83(7):1262-70.PMID: 16511862 [PubMed - indexed for MEDLINE]Related articles

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.

Shen Y, Joachimiak A, Rosner MR, Tang WJ.

Nature. 2006 Oct 19;443(7113):870-4. Epub 2006 Oct 11.PMID: 17051221 [PubMed - indexed for MEDLINE]Related articles

Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation.

Castillo GM, Cummings JA, Yang W, Judge ME, Sheardown MJ, Rimvall K, Hansen JB, Snow AD.

Diabetes. 1998 Apr;47(4):612-20.PMID: 9568695 [PubMed - indexed for MEDLINE]Related articlesFree article

Amylin in pancreatic islets and pancreatic endocrine neoplasms.

Tomita T.

Pathol Int. 2003 Sep;53(9):591-5.PMID: 14507315 [PubMed - indexed for MEDLINE]Related articles

Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation.

Cordes CM, Bennett RG, Siford GL, Hamel FG.

Biochem Pharmacol. 2009 Mar 15;77(6):1064-73. Epub 2008 Dec 27.PMID: 19154729 [PubMed - indexed for MEDLINE]Related articles

[Experimental study of amylin-induced functional damage to rat pancreatic islet cells in vitro]

Zhou L, Xue YM.

Di Yi Jun Yi Da Xue Xue Bao. 2003 Sep;23(9):922-4. Chinese. PMID: 13129721 [PubMed - indexed for MEDLINE]Related articles

Amyloid fibril toxicity in Alzheimer's disease and diabetes.

Lorenzo A, Yankner BA.

Ann N Y Acad Sci. 1996 Jan 17;777:89-95. Review.PMID: 8624132 [PubMed - indexed for MEDLINE]Related articles

Islet amyloid polypeptide/amylin messenger RNA and protein expression in human insulinomas in relation to amyloid formation.

van Hulst KL, Oosterwijk C, Born W, Vroom TM, Nieuwenhuis MG, Blankenstein MA, Lips CJ, Fischer JA, Höppener JW.

Eur J Endocrinol. 1999 Jan;140(1):69-78.PMID: 10037255 [PubMed - indexed for MEDLINE]Related articlesFree article

Investigation into the presence of insulin-degrading enzyme in cultured type II alveolar cells and the effects of enzyme inhibitors on pulmonary bioavailability of insulin in rats.

Hsu MC, Bai JP.

J Pharm Pharmacol. 1998 May;50(5):507-14.PMID: 9643444 [PubMed - indexed for MEDLINE]Related articles

Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.

Pérez A, Morelli L, Cresto JC, Castaño EM.

Neurochem Res. 2000 Feb;25(2):247-55.PMID: 10786709 [PubMed - indexed for MEDLINE]Related articles

Transepithelial transport of insulin: I. Insulin degradation by insulin-degrading enzyme in small intestinal epithelium.

Bai JP, Chang LL.

Pharm Res. 1995 Aug;12(8):1171-5.PMID: 7494830 [PubMed - indexed for MEDLINE]Related articles

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus.

Lorenzo A, Razzaboni B, Weir GC, Yankner BA.

Nature. 1994 Apr 21;368(6473):756-60.PMID: 8152488 [PubMed - indexed for MEDLINE]Related articles

Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.

Zhao L, Teter B, Morihara T, Lim GP, Ambegaokar SS, Ubeda OJ, Frautschy SA, Cole GM.

J Neurosci. 2004 Dec 8;24(49):11120-6.PMID: 15590928 [PubMed - indexed for MEDLINE]Related articlesFree article