PubMed

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid.

Butler AE, Janson J, Soeller WC, Butler PC.

Diabetes. 2003 Sep;52(9):2304-14.PMID: 12941770 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes.

Butler AE, Jang J, Gurlo T, Carty MD, Soeller WC, Butler PC.

Diabetes. 2004 Jun;53(6):1509-16.PMID: 15161755 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes.

Matveyenko AV, Butler PC.

Diabetes. 2006 Jul;55(7):2106-14.PMID: 16804082 [PubMed - indexed for MEDLINE]Related articlesFree article

Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice.

Lin CY, Gurlo T, Kayed R, Butler AE, Haataja L, Glabe CG, Butler PC.

Diabetes. 2007 May;56(5):1324-32. Epub 2007 Mar 12.PMID: 17353506 [PubMed - indexed for MEDLINE]Related articlesFree article

Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis.

Ritzel RA, Butler PC.

Diabetes. 2003 Jul;52(7):1701-8.PMID: 12829636 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes.

Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC.

Diabetes. 2003 Jan;52(1):102-10.PMID: 12502499 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes.

Matveyenko AV, Butler PC.

ILAR J. 2006;47(3):225-33. Review.PMID: 16804197 [PubMed - indexed for MEDLINE]Related articlesFree article

Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress.

Matveyenko AV, Gurlo T, Daval M, Butler AE, Butler PC.

Diabetes. 2009 Apr;58(4):906-16. Epub 2009 Jan 16.PMID: 19151199 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

Andrikopoulos S, Verchere CB, Terauchi Y, Kadowaki T, Kahn SE.

Diabetes. 2000 Dec;49(12):2056-62.PMID: 11118007 [PubMed - indexed for MEDLINE]Related articlesFree article

Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model.

Höppener JW, Oosterwijk C, Nieuwenhuis MG, Posthuma G, Thijssen JH, Vroom TM, Ahrén B, Lips CJ.

Diabetologia. 1999 Apr;42(4):427-34.PMID: 10230646 [PubMed - indexed for MEDLINE]Related articles

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes.

Huang CJ, Lin CY, Haataja L, Gurlo T, Butler AE, Rizza RA, Butler PC.

Diabetes. 2007 Aug;56(8):2016-27. Epub 2007 May 2.PMID: 17475933 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide.

Huang CJ, Haataja L, Gurlo T, Butler AE, Wu X, Soeller WC, Butler PC.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1656-62. Epub 2007 Oct 2.PMID: 17911343 [PubMed - indexed for MEDLINE]Related articlesFree article

An in vitro model of early islet amyloid polypeptide (IAPP) fibrillogenesis using human IAPP-transgenic mouse islets.

Henson MS, Buman BL, Jordan K, Rahrmann EP, Hardy RM, Johnson KH, O'Brien TD.

Amyloid. 2006 Dec;13(4):250-9.PMID: 17107885 [PubMed - indexed for MEDLINE]Related articles

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.

Janson J, Soeller WC, Roche PC, Nelson RT, Torchia AJ, Kreutter DK, Butler PC.

Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7283-8.PMID: 8692984 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes.

Hull RL, Westermark GT, Westermark P, Kahn SE.

J Clin Endocrinol Metab. 2004 Aug;89(8):3629-43. Review.PMID: 15292279 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet amyloid polypeptide and type 2 diabetes.

Marzban L, Park K, Verchere CB.

Exp Gerontol. 2003 Apr;38(4):347-51. Review.PMID: 12670620 [PubMed - indexed for MEDLINE]Related articles

Human islet amyloid polypeptide transgenic mice: in vivo and ex vivo models for the role of hIAPP in type 2 diabetes mellitus.

Höppener JW, Jacobs HM, Wierup N, Sotthewes G, Sprong M, de Vos P, Berger R, Sundler F, Ahrén B.

Exp Diabetes Res. 2008;2008:697035.PMID: 18497871 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid.

Hull RL, Andrikopoulos S, Verchere CB, Vidal J, Wang F, Cnop M, Prigeon RL, Kahn SE.

Diabetes. 2003 Feb;52(2):372-9.PMID: 12540610 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis.

Haataja L, Gurlo T, Huang CJ, Butler PC.

Endocr Rev. 2008 May;29(3):303-16. Epub 2008 Feb 26. Review.PMID: 18314421 [PubMed - indexed for MEDLINE]Related articlesFree article

Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.

de Koning EJ, Morris ER, Hofhuis FM, Posthuma G, Höppener JW, Morris JF, Capel PJ, Clark A, Verbeek JS.

Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8467-71.PMID: 8078905 [PubMed - indexed for MEDLINE]Related articlesFree article