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    Results: 1 to 20 of 161

    1.

    Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.

    Valverde AM, Burks DJ, Fabregat I, Fisher TL, Carretero J, White MF, Benito M.

    Diabetes. 2003 Sep;52(9):2239-48.PMID: 12941762 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes.

    Valverde AM, Fabregat I, Burks DJ, White MF, Benito M.

    Hepatology. 2004 Dec;40(6):1285-94.PMID: 15565601 [PubMed - indexed for MEDLINE]Related articles

    3.

    Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes.

    Fasshauer M, Klein J, Ueki K, Kriauciunas KM, Benito M, White MF, Kahn CR.

    J Biol Chem. 2000 Aug 18;275(33):25494-501.PMID: 10829031 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation.

    Mur C, Arribas M, Benito M, Valverde AM.

    Endocrinology. 2003 Feb;144(2):581-93.PMID: 12538620 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.

    Gonzalez-Rodriguez A, Clampit JE, Escribano O, Benito M, Rondinone CM, Valverde AM.

    Endocrinology. 2007 Feb;148(2):594-608. Epub 2006 Oct 26.PMID: 17068137 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes.

    Valverde AM, Arribas M, Mur C, Navarro P, Pons S, Cassard-Doulcier AM, Kahn CR, Benito M.

    J Biol Chem. 2003 Mar 21;278(12):10221-31. Epub 2003 Jan 13.PMID: 12525499 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes.

    Matsumoto M, Ogawa W, Teshigawara K, Inoue H, Miyake K, Sakaue H, Kasuga M.

    Diabetes. 2002 Jun;51(6):1672-80.PMID: 12031952 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes.

    Fasshauer M, Klein J, Kriauciunas KM, Ueki K, Benito M, Kahn CR.

    Mol Cell Biol. 2001 Jan;21(1):319-29.PMID: 11113206 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity.

    Wada T, Sasaoka T, Funaki M, Hori H, Murakami S, Ishiki M, Haruta T, Asano T, Ogawa W, Ishihara H, Kobayashi M.

    Mol Cell Biol. 2001 Mar;21(5):1633-46.PMID: 11238900 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats.

    Ogihara T, Asano T, Ando K, Chiba Y, Sekine N, Sakoda H, Anai M, Onishi Y, Fujishiro M, Ono H, Shojima N, Inukai K, Fukushima Y, Kikuchi M, Fujita T.

    Diabetes. 2001 Mar;50(3):573-83.PMID: 11246877 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism.

    Miele C, Riboulet A, Maitan MA, Oriente F, Romano C, Formisano P, Giudicelli J, Beguinot F, Van Obberghen E.

    J Biol Chem. 2003 Nov 28;278(48):47376-87. Epub 2003 Sep 11.PMID: 12970360 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.

    Valverde AM, Kahn CR, Benito M.

    Diabetes. 1999 Nov;48(11):2122-31.PMID: 10535444 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells.

    D'Alessandris C, Andreozzi F, Federici M, Cardellini M, Brunetti A, Ranalli M, Del Guerra S, Lauro D, Del Prato S, Marchetti P, Lauro R, Sesti G.

    FASEB J. 2004 Jun;18(9):959-61. Epub 2004 Apr 1.PMID: 15059979 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Growth hormone induces cellular insulin resistance by uncoupling phosphatidylinositol 3-kinase and its downstream signals in 3T3-L1 adipocytes.

    Takano A, Haruta T, Iwata M, Usui I, Uno T, Kawahara J, Ueno E, Sasaoka T, Kobayashi M.

    Diabetes. 2001 Aug;50(8):1891-900.PMID: 11473053 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.

    Schattenberg JM, Wang Y, Singh R, Rigoli RM, Czaja MJ.

    J Biol Chem. 2005 Mar 18;280(11):9887-94. Epub 2005 Jan 4.PMID: 15632182 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes.

    Miura A, Sajan MP, Standaert ML, Bandyopadhyay G, Kahn CR, Farese RV.

    Biochemistry. 2004 Dec 14;43(49):15503-9.PMID: 15581362 [PubMed - indexed for MEDLINE]Related articles

    17.

    Selective interaction between leptin and insulin signaling pathways in a hepatic cell line.

    Szanto I, Kahn CR.

    Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2355-60.PMID: 10688912 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Elevated basal PI 3-kinase activity and reduced insulin signaling in sucrose-induced hepatic insulin resistance.

    Pagliassotti MJ, Kang J, Thresher JS, Sung CK, Bizeau ME.

    Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E170-6.PMID: 11739098 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Effects of streptozocin diabetes and diabetes treatment by islet transplantation on in vivo insulin signaling in rat heart.

    Laviola L, Belsanti G, Davalli AM, Napoli R, Perrini S, Weir GC, Giorgino R, Giorgino F.

    Diabetes. 2001 Dec;50(12):2709-20.PMID: 11723053 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism.

    Taniguchi CM, Ueki K, Kahn R.

    J Clin Invest. 2005 Mar;115(3):718-27. Erratum in: J Clin Invest. 2005 May;115(5):1388. PMID: 15711641 [PubMed - indexed for MEDLINE]Related articlesFree article

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