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    Results: 1 to 20 of 210

    1.

    A novel insulin analog with unique properties: LysB3,GluB29 insulin induces prominent activation of insulin receptor substrate 2, but marginal phosphorylation of insulin receptor substrate 1.

    Rakatzi I, Ramrath S, Ledwig D, Dransfeld O, Bartels T, Seipke G, Eckel J.

    Diabetes. 2003 Sep;52(9):2227-38.PMID: 12941761 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes.

    Mur C, Valverde AM, Kahn CR, Benito M.

    Diabetes. 2002 Mar;51(3):743-54.PMID: 11872675 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling.

    Kim B, Cheng HL, Margolis B, Feldman EL.

    J Biol Chem. 1998 Dec 18;273(51):34543-50.PMID: 9852124 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts.

    Takahashi Y, Tobe K, Kadowaki H, Katsumata D, Fukushima Y, Yazaki Y, Akanuma Y, Kadowaki T.

    Endocrinology. 1997 Feb;138(2):741-50.PMID: 9003010 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Insulin receptor substrate-1 enhances growth hormone-induced proliferation.

    Liang L, Zhou T, Jiang J, Pierce JH, Gustafson TA, Frank SJ.

    Endocrinology. 1999 May;140(5):1972-83.PMID: 10218944 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Effects of streptozocin diabetes and diabetes treatment by islet transplantation on in vivo insulin signaling in rat heart.

    Laviola L, Belsanti G, Davalli AM, Napoli R, Perrini S, Weir GC, Giorgino R, Giorgino F.

    Diabetes. 2001 Dec;50(12):2709-20.PMID: 11723053 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control.

    Parpal S, Karlsson M, Thorn H, Strålfors P.

    J Biol Chem. 2001 Mar 30;276(13):9670-8. Epub 2000 Dec 19.PMID: 11121405 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways.

    Sasaoka T, Ishiki M, Sawa T, Ishihara H, Takata Y, Imamura T, Usui I, Olefsky JM, Kobayashi M.

    Endocrinology. 1996 Oct;137(10):4427-34.PMID: 8828504 [PubMed - indexed for MEDLINE]Related articles

    9.

    Tyrosine phosphorylation-dependent and -independent role of Shc in the regulation of IGF-1-induced mitogenesis and glycogen synthesis.

    Sasaoka T, Ishiki M, Wada T, Hori H, Hirai H, Haruta T, Ishihara H, Kobayashi M.

    Endocrinology. 2001 Dec;142(12):5226-35.PMID: 11713219 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Growth hormone stimulates the tyrosine kinase activity of JAK2 and induces tyrosine phosphorylation of insulin receptor substrates and Shc in rat tissues.

    Thirone AC, Carvalho CR, Saad MJ.

    Endocrinology. 1999 Jan;140(1):55-62.PMID: 9886807 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Differential phosphorylation of IRS-1 and IRS-2 by insulin and IGF-I receptors.

    Rakatzi I, Stosik M, Gromke T, Siddle K, Eckel J.

    Arch Physiol Biochem. 2006 Feb;112(1):37-47.PMID: 16754202 [PubMed - indexed for MEDLINE]Related articles

    12.

    Differential modulation of the tyrosine phosphorylation state of the insulin receptor by IRS (insulin receptor subunit) proteins.

    Solow BT, Harada S, Goldstein BJ, Smith JA, White MF, Jarett L.

    Mol Endocrinol. 1999 Oct;13(10):1784-98.PMID: 10517679 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Augmented growth response to IGF-1 via increased IRS-1 in Chinese hamster ovary cells expressing kinase-negative insulin receptors.

    Inoue S, Fukuda K, Kudara T, Igura T, Inui Y, Tamura S, Hanafusa T, Kawata S, Matsuzawa Y.

    Diabetologia. 1999 Jun;42(6):763-72.PMID: 10382598 [PubMed - indexed for MEDLINE]Related articles

    14.

    Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phosphoinositide 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects.

    Krook A, Whitehead JP, Dobson SP, Griffiths MR, Ouwens M, Baker C, Hayward AC, Sen SK, Maassen JA, Siddle K, Tavaré JM, O'Rahilly S.

    J Biol Chem. 1997 Nov 28;272(48):30208-14.PMID: 9374504 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model.

    Weng LP, Smith WM, Brown JL, Eng C.

    Hum Mol Genet. 2001 Mar 15;10(6):605-16.PMID: 11230180 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10.

    Dey BR, Frick K, Lopaczynski W, Nissley SP, Furlanetto RW.

    Mol Endocrinol. 1996 Jun;10(6):631-41.PMID: 8776723 [PubMed - indexed for MEDLINE]Related articles

    17.

    Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor.

    Schreyer S, Ledwig D, Rakatzi I, Klöting I, Eckel J.

    Endocrinology. 2003 Apr;144(4):1211-8.PMID: 12639902 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Shc and CEACAM1 interact to regulate the mitogenic action of insulin.

    Poy MN, Ruch RJ, Fernstrom MA, Okabayashi Y, Najjar SM.

    J Biol Chem. 2002 Jan 11;277(2):1076-84. Epub 2001 Nov 1.PMID: 11694516 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Insulin signals to prenyltransferases via the Shc branch of intracellular signaling.

    Goalstone ML, Leitner JW, Berhanu P, Sharma PM, Olefsky JM, Draznin B.

    J Biol Chem. 2001 Apr 20;276(16):12805-12. Epub 2001 Jan 25.PMID: 11278505 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.

    Sasaoka T, Draznin B, Leitner JW, Langlois WJ, Olefsky JM.

    J Biol Chem. 1994 Apr 8;269(14):10734-8.PMID: 8144662 [PubMed - indexed for MEDLINE]Related articlesFree article

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