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    Results: 1 to 20 of 166

    1.

    Pancreatic beta-cell lipotoxicity induced by overexpression of hormone-sensitive lipase.

    Winzell MS, Svensson H, Enerbäck S, Ravnskjaer K, Mandrup S, Esser V, Arner P, Alves-Guerra MC, Miroux B, Sundler F, Ahrén B, Holm C.

    Diabetes. 2003 Aug;52(8):2057-65.PMID: 12882923 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c.

    Yamashita T, Eto K, Okazaki Y, Yamashita S, Yamauchi T, Sekine N, Nagai R, Noda M, Kadowaki T.

    Endocrinology. 2004 Aug;145(8):3566-77. Epub 2004 Apr 1.PMID: 15059954 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

    Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB.

    J Biol Chem. 2004 Dec 3;279(49):51049-56. Epub 2004 Sep 23.PMID: 15448158 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis.

    Reid BN, Ables GP, Otlivanchik OA, Schoiswohl G, Zechner R, Blaner WS, Goldberg IJ, Schwabe RF, Chua SC Jr, Huang LS.

    J Biol Chem. 2008 May 9;283(19):13087-99. Epub 2008 Mar 12.PMID: 18337240 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Downregulation of islet hormone-sensitive lipase during long-term high-fat feeding.

    Winzell MS, Holm C, Ahrén B.

    Biochem Biophys Res Commun. 2003 May 2;304(2):273-8.PMID: 12711310 [PubMed - indexed for MEDLINE]Related articles

    6.

    A role for hormone-sensitive lipase in glucose-stimulated insulin secretion: a study in hormone-sensitive lipase-deficient mice.

    Roduit R, Masiello P, Wang SP, Li H, Mitchell GA, Prentki M.

    Diabetes. 2001 Sep;50(9):1970-5.PMID: 11522661 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1.

    Peyot ML, Nolan CJ, Soni K, Joly E, Lussier R, Corkey BE, Wang SP, Mitchell GA, Prentki M.

    Diabetes. 2004 Jul;53(7):1733-42.PMID: 15220197 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes.

    Laybutt DR, Weir GC, Kaneto H, Lebet J, Palmiter RD, Sharma A, Bonner-Weir S.

    Diabetes. 2002 Jun;51(6):1793-804.PMID: 12031967 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Altered beta-cell distribution of pdx-1 and GLUT-2 after a short-term challenge with a high-fat diet in C57BL/6J mice.

    Reimer MK, Ahrén B.

    Diabetes. 2002 Feb;51 Suppl 1:S138-43.PMID: 11815473 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells.

    Takahashi A, Motomura K, Kato T, Yoshikawa T, Nakagawa Y, Yahagi N, Sone H, Suzuki H, Toyoshima H, Yamada N, Shimano H.

    Diabetes. 2005 Feb;54(2):492-9.PMID: 15677507 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice.

    Sekiya M, Yahagi N, Tamura Y, Okazaki H, Igarashi M, Ohta K, Takanashi M, Kumagai M, Takase S, Nishi M, Takeuchi Y, Izumida Y, Kubota M, Ohashi K, Iizuka Y, Yagyu H, Gotoda T, Nagai R, Shimano H, Yamada N, Kadowaki T, Ishibashi S, Osuga J.

    Biochem Biophys Res Commun. 2009 Sep 25;387(3):511-5. Epub 2009 Jul 18.PMID: 19619509 [PubMed - indexed for MEDLINE]Related articles

    12.

    Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice.

    Ueno M, Suzuki J, Zenimaru Y, Takahashi S, Koizumi T, Noriki S, Yamaguchi O, Otsu K, Shen WJ, Kraemer FB, Miyamori I.

    Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1109-18. Epub 2008 Apr 15.PMID: 18413675 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact.

    Fex M, Olofsson CS, Fransson U, Bacos K, Lindvall H, Sörhede-Winzell M, Rorsman P, Holm C, Mulder H.

    Endocrinology. 2004 Aug;145(8):3746-53. Epub 2004 May 13.PMID: 15142983 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    The Tet-On system in transgenic mice: inhibition of the mouse pdx-1 gene activity by antisense RNA expression in pancreatic beta-cells.

    Lottmann H, Vanselow J, Hessabi B, Walther R.

    J Mol Med. 2001 Jun;79(5-6):321-8.PMID: 11485027 [PubMed - indexed for MEDLINE]Related articles

    15.

    Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition.

    Patanè G, Anello M, Piro S, Vigneri R, Purrello F, Rabuazzo AM.

    Diabetes. 2002 Sep;51(9):2749-56.PMID: 12196468 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet.

    Matsui J, Terauchi Y, Kubota N, Takamoto I, Eto K, Yamashita T, Komeda K, Yamauchi T, Kamon J, Kita S, Noda M, Kadowaki T.

    Diabetes. 2004 Nov;53(11):2844-54.PMID: 15504964 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Pancreatic beta-cell lipoprotein lipase independently regulates islet glucose metabolism and normal insulin secretion.

    Pappan KL, Pan Z, Kwon G, Marshall CA, Coleman T, Goldberg IJ, McDaniel ML, Semenkovich CF.

    J Biol Chem. 2005 Mar 11;280(10):9023-9. Epub 2005 Jan 6.PMID: 15637076 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids.

    Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V.

    Diabetes. 2001 Feb;50(2):315-21.PMID: 11272142 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Regulation of lipolytic activity by long-chain acyl-coenzyme A in islets and adipocytes.

    Hu L, Deeney JT, Nolan CJ, Peyot ML, Ao A, Richard AM, Luc E, Faergeman NJ, Knudsen J, Guo W, Sorhede-Winzell M, Prentki M, Corkey BE.

    Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1085-92. Epub 2005 Aug 9.PMID: 16091387 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B.

    Walz HA, Härndahl L, Wierup N, Zmuda-Trzebiatowska E, Svennelid F, Manganiello VC, Ploug T, Sundler F, Degerman E, Ahrén B, Holst LS.

    J Endocrinol. 2006 Jun;189(3):629-41.PMID: 16731793 [PubMed - indexed for MEDLINE]Related articlesFree article

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