PubMed

Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats.

Li G, Mobbs CV, Scarpace PJ.

Diabetes. 2003 Aug;52(8):1951-7.PMID: 12882910 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats.

Li G, Zhang Y, Wilsey JT, Scarpace PJ.

Diabetologia. 2005 Nov;48(11):2376-85. Epub 2005 Oct 5.PMID: 16205885 [PubMed - indexed for MEDLINE]Related articles

Lean rats with hypothalamic pro-opiomelanocortin overexpression exhibit greater diet-induced obesity and impaired central melanocortin responsiveness.

Li G, Zhang Y, Cheng KY, Scarpace PJ.

Diabetologia. 2007 Jul;50(7):1490-9. Epub 2007 May 16.PMID: 17505816 [PubMed - indexed for MEDLINE]Related articles

Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus.

Dhillon H, Kalra SP, Kalra PS.

Mol Ther. 2001 Aug;4(2):139-45.PMID: 11482985 [PubMed - indexed for MEDLINE]Related articlesFree article

Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study.

Dhillon H, Kalra SP, Prima V, Zolotukhin S, Scarpace PJ, Moldawer LL, Muzyczka N, Kalra PS.

Regul Pept. 2001 Jun 15;99(2-3):69-77.PMID: 11384767 [PubMed - indexed for MEDLINE]Related articles

Central leptin gene therapy fails to overcome leptin resistance associated with diet-induced obesity.

Wilsey J, Zolotukhin S, Prima V, Scarpace PJ.

Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R1011-20.PMID: 14557234 [PubMed - indexed for MEDLINE]Related articles

Neuronal histamine regulates food intake, adiposity, and uncoupling protein expression in agouti yellow (A(y)/a) obese mice.

Masaki T, Chiba S, Yoshimichi G, Yasuda T, Noguchi H, Kakuma T, Sakata T, Yoshimatsu H.

Endocrinology. 2003 Jun;144(6):2741-8.PMID: 12746338 [PubMed - indexed for MEDLINE]Related articlesFree article

Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss.

Li G, Zhang Y, Rodrigues E, Zheng D, Matheny M, Cheng KY, Scarpace PJ.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E252-8. Epub 2007 Mar 27.PMID: 17389713 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats.

Li G, Klein RL, Matheny M, King MA, Meyer EM, Scarpace PJ.

Neuroscience. 2002;115(3):879-89.PMID: 12435426 [PubMed - indexed for MEDLINE]Related articles

Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus.

Korner J, Savontaus E, Chua SC Jr, Leibel RL, Wardlaw SL.

J Neuroendocrinol. 2001 Nov;13(11):959-66.PMID: 11737554 [PubMed - indexed for MEDLINE]Related articles

Evidence for the existence of distinct central appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic site-specific leptin gene therapy.

Bagnasco M, Dube MG, Kalra PS, Kalra SP.

Endocrinology. 2002 Nov;143(11):4409-21.PMID: 12399438 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats.

Havel PJ, Hahn TM, Sindelar DK, Baskin DG, Dallman MF, Weigle DS, Schwartz MW.

Diabetes. 2000 Feb;49(2):244-52.PMID: 10868941 [PubMed - indexed for MEDLINE]Related articlesFree article

Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: increase in serum ghrelin levels.

Dube MG, Beretta E, Dhillon H, Ueno N, Kalra PS, Kalra SP.

Diabetes. 2002 Jun;51(6):1729-36.PMID: 12031959 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of leptin receptor mutation on Agrp gene expression in fed and fasted lean and obese (LA/N-faf) rats.

Korner J, Wardlaw SL, Liu SM, Conwell IM, Leibel RL, Chua SC Jr.

Endocrinology. 2000 Jul;141(7):2465-71.PMID: 10875247 [PubMed - indexed for MEDLINE]Related articlesFree article

Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice.

Masaki T, Yoshimatsu H, Chiba S, Watanabe T, Sakata T.

Diabetes. 2001 Feb;50(2):376-84.PMID: 11272150 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: effects on serum ghrelin and appetite-regulating genes.

Beretta E, Dube MG, Kalra PS, Kalra SP.

Pediatr Res. 2002 Aug;52(2):189-98.PMID: 12149495 [PubMed - indexed for MEDLINE]Related articles

The effect of moxonidine on feeding and body fat in obese Zucker rats: role of hypothalamic NPY neurones.

Bing C, King P, Pickavance L, Brown M, Ziegler D, Kaan E, Williams G.

Br J Pharmacol. 1999 May;127(1):35-42.PMID: 10369453 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus.

Schwartz MW, Seeley RJ, Woods SC, Weigle DS, Campfield LA, Burn P, Baskin DG.

Diabetes. 1997 Dec;46(12):2119-23.PMID: 9392508 [PubMed - indexed for MEDLINE]Related articles

Peripheral, but not central, administration of adiponectin reduces visceral adiposity and upregulates the expression of uncoupling protein in agouti yellow (Ay/a) obese mice.

Masaki T, Chiba S, Yasuda T, Tsubone T, Kakuma T, Shimomura I, Funahashi T, Matsuzawa Y, Yoshimatsu H.

Diabetes. 2003 Sep;52(9):2266-73.PMID: 12941765 [PubMed - indexed for MEDLINE]Related articlesFree article

Obesity in insulin receptor substrate-2-deficient mice: disrupted control of arcuate nucleus neuropeptides.

Masaki T, Chiba S, Noguchi H, Yasuda T, Tobe K, Suzuki R, Kadowaki T, Yoshimatsu H.

Obes Res. 2004 May;12(5):878-85.PMID: 15166310 [PubMed - indexed for MEDLINE]Related articles