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    Results: 1 to 20 of 200

    1.

    Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise.

    Beeson M, Sajan MP, Dizon M, Grebenev D, Gomez-Daspet J, Miura A, Kanoh Y, Powe J, Bandyopadhyay G, Standaert ML, Farese RV.

    Diabetes. 2003 Aug;52(8):1926-34.PMID: 12882907 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Skeletal muscle insulin resistance in obesity-associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota.

    Standaert ML, Ortmeyer HK, Sajan MP, Kanoh Y, Bandyopadhyay G, Hansen BC, Farese RV.

    Diabetes. 2002 Oct;51(10):2936-43.PMID: 12351430 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects.

    Luna V, Casauban L, Sajan MP, Gomez-Daspet J, Powe JL, Miura A, Rivas J, Standaert ML, Farese RV.

    Diabetologia. 2006 Feb;49(2):375-82. Epub 2006 Jan 5.PMID: 16395615 [PubMed - indexed for MEDLINE]Related articles

    4.

    Rosiglitazone, insulin treatment, and fasting correct defective activation of protein kinase C-zeta/lambda by insulin in vastus lateralis muscles and adipocytes of diabetic rats.

    Kanoh Y, Bandyopadhyay G, Sajan MP, Standaert ML, Farese RV.

    Endocrinology. 2001 Apr;142(4):1595-605.PMID: 11250941 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Impaired activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 in cultured preadipocyte-derived adipocytes and myotubes of obese subjects.

    Sajan MP, Standaert ML, Miura A, Bandyopadhyay G, Vollenweider P, Franklin DM, Lea-Currie R, Farese RV.

    J Clin Endocrinol Metab. 2004 Aug;89(8):3994-8.PMID: 15292339 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Defective activation of atypical protein kinase C zeta and lambda by insulin and phosphatidylinositol-3,4,5-(PO4)(3) in skeletal muscle of rats following high-fat feeding and streptozotocin-induced diabetes.

    Kanoh Y, Sajan MP, Bandyopadhyay G, Miura A, Standaert ML, Farese RV.

    Endocrinology. 2003 Mar;144(3):947-54.PMID: 12586772 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle.

    Temofonte N, Sajan MP, Nimal S, Pastoor T, Fumero C, Casaubon L, Powe JL, Standaert ML, Farese RV.

    Diabetologia. 2009 Jan;52(1):60-4. Epub 2008 Oct 30.PMID: 18972094 [PubMed - indexed for MEDLINE]Related articles

    8.

    Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction.

    Kim YB, Kotani K, Ciaraldi TP, Henry RR, Kahn BB.

    Diabetes. 2003 Aug;52(8):1935-42.PMID: 12882908 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients [corrected].

    Storgaard H, Song XM, Jensen CB, Madsbad S, Björnholm M, Vaag A, Zierath JR.

    Diabetes. 2001 Dec;50(12):2770-8. Erratum in: Diabetes 2002 Feb;51(2):552. PMID: 11723060 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities.

    Tremblay F, Lavigne C, Jacques H, Marette A.

    Diabetes. 2001 Aug;50(8):1901-10.PMID: 11473054 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients.

    Miyazaki Y, He H, Mandarino LJ, DeFronzo RA.

    Diabetes. 2003 Aug;52(8):1943-50.PMID: 12882909 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes.

    Farese RV, Sajan MP, Standaert ML.

    Exp Biol Med (Maywood). 2005 Oct;230(9):593-605. Review.PMID: 16179727 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes.

    Storgaard H, Jensen CB, Björnholm M, Song XM, Madsbad S, Zierath JR, Vaag AA.

    J Clin Endocrinol Metab. 2004 Mar;89(3):1301-11.PMID: 15001626 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Insulin-stimulated plasma membrane association and activation of Akt2, aPKC zeta and aPKC lambda in high fat fed rodent skeletal muscle.

    Herr HJ, Bernard JR, Reeder DW, Rivas DA, Limon JJ, Yaspelkis BB 3rd.

    J Physiol. 2005 Jun 1;565(Pt 2):627-36. Epub 2005 Mar 31.PMID: 15802290 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans.

    Casaubon L, Sajan MP, Rivas J, Powe JL, Standaert ML, Farese RV.

    Diabetologia. 2006 Dec;49(12):3000-8. Epub 2006 Oct 7.PMID: 17028898 [PubMed - indexed for MEDLINE]Related articles

    16.

    Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle.

    Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM.

    Diabetes. 2005 Aug;54(8):2351-9.PMID: 16046301 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats.

    Song XM, Kawano Y, Krook A, Ryder JW, Efendic S, Roth RA, Wallberg-Henriksson H, Zierath JR.

    Diabetes. 1999 Mar;48(3):664-70.PMID: 10078575 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Evidence against a role for insulin-signaling proteins PI 3-kinase and Akt in insulin resistance in human skeletal muscle induced by short-term GH infusion.

    Jessen N, Djurhuus CB, Jørgensen JO, Jensen LS, Møller N, Lund S, Schmitz O.

    Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E194-9. Epub 2004 Aug 31.PMID: 15339744 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells palmitate rather than tumour necrosis factor inhibits insulin-dependent protein kinase B (PKB)/Akt stimulation and glucose uptake.

    Storz P, Döppler H, Wernig A, Pfizenmaier K, Müller G.

    Eur J Biochem. 1999 Nov;266(1):17-25.PMID: 10542046 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3' kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance.

    Vollenweider P, Ménard B, Nicod P.

    Diabetes. 2002 Apr;51(4):1052-9.PMID: 11916925 [PubMed - indexed for MEDLINE]Related articlesFree article

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