PubMed

Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis.

Kim H, Haluzik M, Asghar Z, Yau D, Joseph JW, Fernandez AM, Reitman ML, Yakar S, Stannard B, Heron-Milhavet L, Wheeler MB, LeRoith D.

Diabetes. 2003 Jul;52(7):1770-8.PMID: 12829645 [PubMed - indexed for MEDLINE]Related articlesFree article

WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice.

Chou CJ, Haluzik M, Gregory C, Dietz KR, Vinson C, Gavrilova O, Reitman ML.

J Biol Chem. 2002 Jul 5;277(27):24484-9. Epub 2002 May 6.PMID: 11994294 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus.

Pennisi P, Gavrilova O, Setser-Portas J, Jou W, Santopietro S, Clemmons D, Yakar S, LeRoith D.

Endocrinology. 2006 Jun;147(6):2619-30. Epub 2006 Mar 2.PMID: 16513827 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice.

Héron-Milhavet L, Haluzik M, Yakar S, Gavrilova O, Pack S, Jou WC, Ibrahimi A, Kim H, Hunt D, Yau D, Asghar Z, Joseph J, Wheeler MB, Abumrad NA, LeRoith D.

Endocrinology. 2004 Oct;145(10):4667-76. Epub 2004 Jul 1.PMID: 15231693 [PubMed - indexed for MEDLINE]Related articlesFree article

Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes.

Zhao H, Yakar S, Gavrilova O, Sun H, Zhang Y, Kim H, Setser J, Jou W, LeRoith D.

Diabetes. 2004 Nov;53(11):2901-9.PMID: 15504971 [PubMed - indexed for MEDLINE]Related articlesFree article

Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues.

Way JM, Harrington WW, Brown KK, Gottschalk WK, Sundseth SS, Mansfield TA, Ramachandran RK, Willson TM, Kliewer SA.

Endocrinology. 2001 Mar;142(3):1269-77.PMID: 11181544 [PubMed - indexed for MEDLINE]Related articlesFree article

Improvement of insulin sensitivity after peroxisome proliferator-activated receptor-alpha agonist treatment is accompanied by paradoxical increase of circulating resistin levels.

Haluzik MM, Lacinova Z, Dolinkova M, Haluzikova D, Housa D, Horinek A, Vernerova Z, Kumstyrova T, Haluzik M.

Endocrinology. 2006 Sep;147(9):4517-24. Epub 2006 Jun 1.PMID: 16740970 [PubMed - indexed for MEDLINE]Related articlesFree article

Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes.

Kim H, Haluzik M, Gavrilova O, Yakar S, Portas J, Sun H, Pajvani UB, Scherer PE, LeRoith D.

Diabetologia. 2004 Dec;47(12):2215-25. Epub 2004 Dec 15.PMID: 15662559 [PubMed - indexed for MEDLINE]Related articles

MKR mice are resistant to the metabolic actions of both insulin and adiponectin: discordance between insulin resistance and adiponectin responsiveness.

Kim CH, Pennisi P, Zhao H, Yakar S, Kaufman JB, Iganaki K, Shiloach J, Scherer PE, Quon MJ, LeRoith D.

Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E298-305. Epub 2006 Feb 28.PMID: 16507604 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor (PPAR)-alpha agonism prevents the onset of type 2 diabetes in Zucker diabetic fatty rats: A comparison with PPAR gamma agonism.

Bergeron R, Yao J, Woods JW, Zycband EI, Liu C, Li Z, Adams A, Berger JP, Zhang BB, Moller DE, Doebber TW.

Endocrinology. 2006 Sep;147(9):4252-62. Epub 2006 May 25.PMID: 16728496 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor alpha is involved in the regulation of lipid metabolism by ginseng.

Yoon M, Lee H, Jeong S, Kim JJ, Nicol CJ, Nam KW, Kim M, Cho BG, Oh GT.

Br J Pharmacol. 2003 Apr;138(7):1295-302.PMID: 12711630 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle-specific Pparg deletion causes insulin resistance.

Hevener AL, He W, Barak Y, Le J, Bandyopadhyay G, Olson P, Wilkes J, Evans RM, Olefsky J.

Nat Med. 2003 Dec;9(12):1491-7. Epub 2003 Nov 16.PMID: 14625542 [PubMed - indexed for MEDLINE]Related articles

A novel peroxisome proliferator-activated receptor alpha/gamma dual agonist demonstrates favorable effects on lipid homeostasis.

Guo Q, Sahoo SP, Wang PR, Milot DP, Ippolito MC, Wu MS, Baffic J, Biswas C, Hernandez M, Lam MH, Sharma N, Han W, Kelly LJ, MacNaul KL, Zhou G, Desai R, Heck JV, Doebber TW, Berger JP, Moller DE, Sparrow CP, Chao YS, Wright SD.

Endocrinology. 2004 Apr;145(4):1640-8. Epub 2003 Dec 30.PMID: 14701675 [PubMed - indexed for MEDLINE]Related articlesFree article

A proteome analysis of livers from obese (ob/ob) mice treated with the peroxisome proliferator WY14,643.

Edvardsson U, Alexandersson M, Brockenhuus von Löwenhielm H, Nyström AC, Ljung B, Nilsson F, Dahllöf B.

Electrophoresis. 1999 Apr-May;20(4-5):935-42.PMID: 10344269 [PubMed - indexed for MEDLINE]Related articles

Effect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice.

Kim H, Pennisi PA, Gavrilova O, Pack S, Jou W, Setser-Portas J, East-Palmer J, Tang Y, Manganiello VC, Leroith D.

Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1227-36.PMID: 16682489 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct mechanisms of glucose lowering by specific agonists for peroxisomal proliferator activated receptor gamma and retinoic acid X receptors.

Li X, Hansen PA, Xi L, Chandraratna RA, Burant CF.

J Biol Chem. 2005 Nov 18;280(46):38317-27. Epub 2005 Sep 22.PMID: 16179348 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor-alpha deficiency does not alter insulin sensitivity in mice maintained on regular or high-fat diet: hyperinsulinemic-euglycemic clamp studies.

Haluzik M, Gavrilova O, LeRoith D.

Endocrinology. 2004 Apr;145(4):1662-7. Epub 2003 Dec 11.PMID: 14670996 [PubMed - indexed for MEDLINE]Related articlesFree article

knocking down liver ccaat/enhancer-binding protein alpha by adenovirus-transduced silent interfering ribonucleic acid improves hepatic gluconeogenesis and lipid homeostasis in db/db mice.

Qiao L, MacLean PS, You H, Schaack J, Shao J.

Endocrinology. 2006 Jun;147(6):3060-9. Epub 2006 Mar 16.PMID: 16543372 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones.

Norris AW, Chen L, Fisher SJ, Szanto I, Ristow M, Jozsi AC, Hirshman MF, Rosen ED, Goodyear LJ, Gonzalez FJ, Spiegelman BM, Kahn CR.

J Clin Invest. 2003 Aug;112(4):608-18.PMID: 12925701 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor (PPAR)-alpha activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: comparison with PPAR-gamma activation.

Ye JM, Doyle PJ, Iglesias MA, Watson DG, Cooney GJ, Kraegen EW.

Diabetes. 2001 Feb;50(2):411-7.PMID: 11272155 [PubMed - indexed for MEDLINE]Related articlesFree article