PubMed

Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis.

Ritzel RA, Butler PC.

Diabetes. 2003 Jul;52(7):1701-8.PMID: 12829636 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid.

Butler AE, Janson J, Soeller WC, Butler PC.

Diabetes. 2003 Sep;52(9):2304-14.PMID: 12941770 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway.

Lin CY, Gurlo T, Haataja L, Hsueh WA, Butler PC.

J Clin Endocrinol Metab. 2005 Dec;90(12):6678-86. Epub 2005 Oct 4.PMID: 16204373 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes.

Butler AE, Jang J, Gurlo T, Carty MD, Soeller WC, Butler PC.

Diabetes. 2004 Jun;53(6):1509-16.PMID: 15161755 [PubMed - indexed for MEDLINE]Related articlesFree article

Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice.

Lin CY, Gurlo T, Kayed R, Butler AE, Haataja L, Glabe CG, Butler PC.

Diabetes. 2007 May;56(5):1324-32. Epub 2007 Mar 12.PMID: 17353506 [PubMed - indexed for MEDLINE]Related articlesFree article

Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets.

Ritzel RA, Meier JJ, Lin CY, Veldhuis JD, Butler PC.

Diabetes. 2007 Jan;56(1):65-71.PMID: 17192466 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes.

Matveyenko AV, Butler PC.

Diabetes. 2006 Jul;55(7):2106-14.PMID: 16804082 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes.

Matveyenko AV, Butler PC.

ILAR J. 2006;47(3):225-33. Review.PMID: 16804197 [PubMed - indexed for MEDLINE]Related articlesFree article

Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress.

Matveyenko AV, Gurlo T, Daval M, Butler AE, Butler PC.

Diabetes. 2009 Apr;58(4):906-16. Epub 2009 Jan 16.PMID: 19151199 [PubMed - indexed for MEDLINE]Related articlesFree article

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

Janson J, Ashley RH, Harrison D, McIntyre S, Butler PC.

Diabetes. 1999 Mar;48(3):491-8.PMID: 10078548 [PubMed - indexed for MEDLINE]Related articlesFree article

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes.

Huang CJ, Lin CY, Haataja L, Gurlo T, Butler AE, Rizza RA, Butler PC.

Diabetes. 2007 Aug;56(8):2016-27. Epub 2007 May 2.PMID: 17475933 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased vulnerability of newly forming beta cells to cytokine-induced cell death.

Meier JJ, Ritzel RA, Maedler K, Gurlo T, Butler PC.

Diabetologia. 2006 Jan;49(1):83-9. Epub 2005 Dec 2.PMID: 16323002 [PubMed - indexed for MEDLINE]Related articles

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.

Janson J, Soeller WC, Roche PC, Nelson RT, Torchia AJ, Kreutter DK, Butler PC.

Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7283-8.PMID: 8692984 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.

Marzban L, Rhodes CJ, Steiner DF, Haataja L, Halban PA, Verchere CB.

Diabetes. 2006 Aug;55(8):2192-201.PMID: 16873681 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet amyloid polypeptide in the islets of Langerhans: friend or foe?

Gebre-Medhin S, Olofsson C, Mulder H.

Diabetologia. 2000 Jun;43(6):687-95. Review.PMID: 10907112 [PubMed - indexed for MEDLINE]Related articles

Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide.

Huang CJ, Haataja L, Gurlo T, Butler AE, Wu X, Soeller WC, Butler PC.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1656-62. Epub 2007 Oct 2.PMID: 17911343 [PubMed - indexed for MEDLINE]Related articlesFree article

Banting lecture 1990. Beta-cells in type II diabetes mellitus.

Porte D Jr.

Diabetes. 1991 Feb;40(2):166-80. Review.PMID: 1991568 [PubMed - indexed for MEDLINE]Related articles

Two novel immortal pancreatic beta-cell lines expressing and secreting human islet amyloid polypeptide do not spontaneously develop islet amyloid.

Andrikopoulos S, Verchere CB, Teague JC, Howell WM, Fujimoto WY, Wight TN, Kahn SE.

Diabetes. 1999 Oct;48(10):1962-70. Erratum in: Diabetes 2000 Jan;49(1):135. PMID: 10512360 [PubMed - indexed for MEDLINE]Related articlesFree article

Amyloid formation in response to beta cell stress occurs in vitro, but not in vivo, in islets of transgenic mice expressing human islet amyloid polypeptide.

Westermark G, Arora MB, Fox N, Carroll R, Chan SJ, Westermark P, Steiner DF.

Mol Med. 1995 Jul;1(5):542-53.PMID: 8529120 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.

Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe CG, Butler PC.

Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1317-24. Epub 2006 Jul 18.PMID: 16849627 [PubMed - indexed for MEDLINE]Related articlesFree article