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    Results: 1 to 20 of 159

    1.

    Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice.

    Kulkarni RN, Almind K, Goren HJ, Winnay JN, Ueki K, Okada T, Kahn CR.

    Diabetes. 2003 Jun;52(6):1528-34.PMID: 12765966 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance.

    Almind K, Kulkarni RN, Lannon SM, Kahn CR.

    Diabetes. 2003 Jun;52(6):1535-43.PMID: 12765967 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.

    Terauchi Y, Iwamoto K, Tamemoto H, Komeda K, Ishii C, Kanazawa Y, Asanuma N, Aizawa T, Akanuma Y, Yasuda K, Kodama T, Tobe K, Yazaki Y, Kadowaki T.

    J Clin Invest. 1997 Mar 1;99(5):861-6.PMID: 9062343 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Genetic modifiers of the insulin resistance phenotype in mice.

    Kido Y, Philippe N, Schäffer AA, Accili D.

    Diabetes. 2000 Apr;49(4):589-96.PMID: 10871196 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles.

    Brüning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR.

    Cell. 1997 Feb 21;88(4):561-72.PMID: 9038347 [PubMed - indexed for MEDLINE]Related articles

    6.

    Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

    Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, Accili D.

    J Clin Invest. 2000 Jan;105(2):199-205.PMID: 10642598 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice.

    Terauchi Y, Matsui J, Suzuki R, Kubota N, Komeda K, Aizawa S, Eto K, Kimura S, Nagai R, Tobe K, Lienhard GE, Kadowaki T.

    J Biol Chem. 2003 Apr 18;278(16):14284-90. Epub 2002 Dec 18.PMID: 12493745 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.

    Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB.

    J Biol Chem. 2007 Aug 17;282(33):23829-40. Epub 2007 Jun 1.PMID: 17545163 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Evidence for a circulating islet cell growth factor in insulin-resistant states.

    Flier SN, Kulkarni RN, Kahn CR.

    Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7475-80. Epub 2001 Jun 12.PMID: 11404474 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Ontogenetic characteristics of enzyme activities and plasma metabolites in C57BL/6J:Jcl mice deficient in insulin receptor substrate 2.

    Hashimoto H, Arai T, Takeguchi A, Hioki K, Ohnishi Y, Kawai K, Ito M, Suzuki R, Yamauchi T, Ohsugi M, Saito M, Ueyama Y, Tobe K, Kadowaki T, Tamaoki N, Kosaka K.

    Comp Med. 2006 Jun;56(3):176-87.PMID: 16774126 [PubMed - indexed for MEDLINE]Related articles

    11.

    Disease model: hyperinsulinemia and insulin resistance. Part A-targeted disruption of insulin signaling or glucose transport.

    Sone H, Suzuki H, Takahashi A, Yamada N.

    Trends Mol Med. 2001 Jul;7(7):320-2. Review.PMID: 11425641 [PubMed - indexed for MEDLINE]Related articles

    12.

    Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.

    Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR.

    J Clin Invest. 2002 Jan;109(1):141-9.PMID: 11781359 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice.

    Kahn CR.

    Trans Am Clin Climatol Assoc. 2003;114:125-48.PMID: 12813916 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Phenotypes of IRS-2 deficient mice produced by reproductive technology are stable.

    Hashimoto H, Arai T, Ohnishi Y, Eto T, Ito M, Hioki K, Suzuki R, Yamauchi T, Ohsugi M, Saito M, Ueyama Y, Tobe K, Kadowaki T, Tamaoki N, Kosaka K.

    Exp Anim. 2007 Apr;56(2):149-54.PMID: 17460360 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Liver-specific IGF-I gene deficient mice exhibit accelerated diabetes in response to streptozotocin, associated with early onset of insulin resistance.

    Yu R, Yakar S, Liu YL, Lu Y, LeRoith D, Miao D, Liu JL.

    Mol Cell Endocrinol. 2003 Jun 30;204(1-2):31-42.PMID: 12850279 [PubMed - indexed for MEDLINE]Related articles

    16.

    Insulin resistance and hyperinsulinaemia in insulin receptor substrate-1 knockout mice.

    Jenkins AB, Storlien LH.

    Diabetologia. 1997 Sep;40(9):1113-4. No abstract available. PMID: 9300252 [PubMed - indexed for MEDLINE]Related articles

    17.

    Allelic variation on chromosome 5 controls beta-cell mass expansion during hyperglycemia in leptin receptor-deficient diabetes mice.

    Luo N, Liu SM, Liu H, Li Q, Xu Q, Sun X, Davis B, Li J, Chua S Jr.

    Endocrinology. 2006 May;147(5):2287-95. Epub 2006 Feb 16.PMID: 16484328 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus.

    Kahn CR, Brüning JC, Michael MD, Kulkarni RN.

    J Pediatr Endocrinol Metab. 2000;13 Suppl 6:1377-84. Review.PMID: 11202213 [PubMed - indexed for MEDLINE]Related articles

    19.

    [Achievements in molecular genetics studies of diabetes mellitus]

    Pankov IuA.

    Biomed Khim. 2005 Mar-Apr;51(2):107-17. Review. Russian. PMID: 15945346 [PubMed - indexed for MEDLINE]Related articles

    20.

    Analysis of compensatory beta-cell response in mice with combined mutations of Insr and Irs2.

    Kim JJ, Kido Y, Scherer PE, White MF, Accili D.

    Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1694-701. Epub 2007 Feb 13.PMID: 17299086 [PubMed - indexed for MEDLINE]Related articlesFree article

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