PubMed

Free fatty acid-mediated impairment of glucose-stimulated insulin secretion in nondiabetic Oji-Cree individuals from the Sandy Lake community of Ontario, Canada: a population at very high risk for developing type 2 diabetes.

Carpentier A, Zinman B, Leung N, Giacca A, Hanley AJ, Harris SB, Hegele RA, Lewis GF.

Diabetes. 2003 Jun;52(6):1485-95.PMID: 12765961 [PubMed - indexed for MEDLINE]Related articlesFree article

A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes.

Kashyap S, Belfort R, Gastaldelli A, Pratipanawatr T, Berria R, Pratipanawatr W, Bajaj M, Mandarino L, DeFronzo R, Cusi K.

Diabetes. 2003 Oct;52(10):2461-74.PMID: 14514628 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes.

Carpentier A, Mittelman SD, Bergman RN, Giacca A, Lewis GF.

Diabetes. 2000 Mar;49(3):399-408.PMID: 10868961 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes.

Boden G, Chen X.

Diabetes. 1999 Mar;48(3):577-83.PMID: 10078559 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats.

Mason TM, Goh T, Tchipashvili V, Sandhu H, Gupta N, Lewis GF, Giacca A.

Diabetes. 1999 Mar;48(3):524-30.PMID: 10078552 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretion after short- and long-term low-grade free fatty acid infusion in men with increased risk of developing type 2 diabetes.

Storgaard H, Jensen CB, Vaag AA, Vølund A, Madsbad S.

Metabolism. 2003 Jul;52(7):885-94.PMID: 12870166 [PubMed - indexed for MEDLINE]Related articles

Elevation of plasma fatty acids by ten-hour intralipid infusion has no effect on basal or glucose-stimulated insulin secretion in normal man.

Amery CM, Round RA, Smith JM, Nattrass M.

Metabolism. 2000 Apr;49(4):450-4.PMID: 10778867 [PubMed - indexed for MEDLINE]Related articles

Effects of an intravenous lipid challenge and free fatty acid elevation on in vivo insulin sensitivity in African American versus Caucasian adolescents.

Burns SF, Kelsey SF, Arslanian SA.

Diabetes Care. 2009 Feb;32(2):355-60. Epub 2008 Nov 18.PMID: 19017772 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of a 48-h fat infusion on insulin secretion and glucose utilization.

Boden G, Chen X, Rosner J, Barton M.

Diabetes. 1995 Oct;44(10):1239-42.PMID: 7556964 [PubMed - indexed for MEDLINE]Related articles

Effects of free fatty acids and glucose on splanchnic insulin dynamics.

Hennes MM, Dua A, Kissebah AH.

Diabetes. 1997 Jan;46(1):57-62.PMID: 8971082 [PubMed - indexed for MEDLINE]Related articles

Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator--activated receptor-gamma2 gene.

Stefan N, Fritsche A, Häring H, Stumvoll M.

Diabetes. 2001 May;50(5):1143-8.PMID: 11334419 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation.

Carpentier A, Mittelman SD, Lamarche B, Bergman RN, Giacca A, Lewis GF.

Am J Physiol. 1999 Jun;276(6 Pt 1):E1055-66.PMID: 10362618 [PubMed - indexed for MEDLINE]Related articlesFree article

Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects.

Paolisso G, Gambardella A, Amato L, Tortoriello R, D'Amore A, Varricchio M, D'Onofrio F.

Diabetologia. 1995 Nov;38(11):1295-9.PMID: 8582538 [PubMed - indexed for MEDLINE]Related articles

Young, low-birth-weight men are not more susceptible to the diabetogenic effects of a prolonged free fatty acid exposure than matched controls.

Jensen CB, Storgaard H, Holst JJ, Dela F, Madsbad S, Vaag A.

Metabolism. 2005 Oct;54(10):1398-406.PMID: 16154442 [PubMed - indexed for MEDLINE]Related articles

The impact of acute elevation of non-esterified fatty acids on insulin sensitivity and secretion in women with former gestational diabetes.

McLachlan KA, Alford FP.

Clin Endocrinol (Oxf). 2005 Jan;62(1):79-84.PMID: 15638874 [PubMed - indexed for MEDLINE]Related articles

Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes.

Cusi K, Kashyap S, Gastaldelli A, Bajaj M, Cersosimo E.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1775-81. Epub 2007 Feb 13.PMID: 17299078 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acids reduce splanchnic and peripheral glucose uptake in patients with type 2 diabetes.

Bajaj M, Pratipanawatr T, Berria R, Pratipanawatr W, Kashyap S, Cusi K, Mandarino L, DeFronzo RA.

Diabetes. 2002 Oct;51(10):3043-8.PMID: 12351445 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes.

Storgaard H, Jensen CB, Björnholm M, Song XM, Madsbad S, Zierath JR, Vaag AA.

J Clin Endocrinol Metab. 2004 Mar;89(3):1301-11.PMID: 15001626 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans.

Lewis GF, Vranic M, Harley P, Giacca A.

Diabetes. 1997 Jul;46(7):1111-9.PMID: 9200644 [PubMed - indexed for MEDLINE]Related articles

Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans.

Dobbins RL, Chester MW, Daniels MB, McGarry JD, Stein DT.

Diabetes. 1998 Oct;47(10):1613-8.PMID: 9753300 [PubMed - indexed for MEDLINE]Related articlesFree article