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    Results: 1 to 20 of 726

    1.

    Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice.

    Liu Y, Nakagawa Y, Wang Y, Li R, Li X, Ohzeki T, Friedman TC.

    Diabetes. 2003 Jun;52(6):1409-16.PMID: 12765951 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice.

    Liu Y, Nakagawa Y, Wang Y, Liu L, Du H, Wang W, Ren X, Lutfy K, Friedman TC.

    J Mol Endocrinol. 2008 Aug;41(2):53-64. Epub 2008 Jun 4.PMID: 18524870 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice.

    Liu Y, Nakagawa Y, Wang Y, Sakurai R, Tripathi PV, Lutfy K, Friedman TC.

    Diabetes. 2005 Jan;54(1):32-40.PMID: 15616008 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Regulation of 11beta-hydroxysteroid dehydrogenase type 1 and glucose-stimulated insulin secretion in pancreatic islets of Langerhans.

    Ortsäter H, Alberts P, Warpman U, Engblom LO, Abrahmsén L, Bergsten P.

    Diabetes Metab Res Rev. 2005 Jul-Aug;21(4):359-66.PMID: 15586384 [PubMed - indexed for MEDLINE]Related articles

    5.

    MRNA and enzyme activity of hepatic 11beta-hydroxysteroid dehydrogenase type 1 are elevated in C57BL/KsJ-db/db mice.

    Aoki K, Homma M, Hirano T, Oka K, Satoh S, Mukasa K, Ito S, Sekihara H.

    Life Sci. 2001 Oct 12;69(21):2543-9.PMID: 11693261 [PubMed - indexed for MEDLINE]Related articles

    6.

    Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice.

    Paterson JM, Morton NM, Fievet C, Kenyon CJ, Holmes MC, Staels B, Seckl JR, Mullins JJ.

    Proc Natl Acad Sci U S A. 2004 May 4;101(18):7088-93. Epub 2004 Apr 26.PMID: 15118095 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Different responsiveness in body weight and hepatic 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 1 mrna to 11beta-HSD inhibition by glycyrrhetinic acid treatment in obese and lean zucker rats.

    Li RS, Nakagawa Y, Nakanishi T, Fujisawa Y, Ohzeki T.

    Metabolism. 2004 May;53(5):600-6.PMID: 15131764 [PubMed - indexed for MEDLINE]Related articles

    8.

    Dysregulation of glucocorticoid metabolism in murine obesity: comparable effects of leptin resistance and deficiency.

    Livingstone DE, Grassick SL, Currie GL, Walker BR, Andrew R.

    J Endocrinol. 2009 May;201(2):211-8. Epub 2009 Feb 17.PMID: 19223399 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice.

    Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte D Jr, Woods SC, Seeley RJ, Weigle DS.

    Diabetes. 1996 Apr;45(4):531-5.PMID: 8603777 [PubMed - indexed for MEDLINE]Related articles

    10.

    11beta-hydroxysteroid dehydrogenase type 1 and obesity.

    Morton NM, Seckl JR.

    Front Horm Res. 2008;36:146-64. Review.PMID: 18230901 [PubMed - indexed for MEDLINE]Related articles

    11.

    Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)--a promising drug target for the treatment of metabolic syndrome.

    Masuzaki H, Flier JS.

    Curr Drug Targets Immune Endocr Metabol Disord. 2003 Dec;3(4):255-62. Review.PMID: 14683456 [PubMed - indexed for MEDLINE]Related articles

    12.

    Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice.

    Liu Y, Yan C, Wang Y, Nakagawa Y, Nerio N, Anghel A, Lutfy K, Friedman TC.

    Endocrinology. 2006 Nov;147(11):5061-8. Epub 2006 Jul 27.PMID: 16873540 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Is 11beta-hydroxysteroid dehydrogenase type 1 a therapeutic target? Effects of carbenoxolone in lean and obese Zucker rats.

    Livingstone DE, Walker BR.

    J Pharmacol Exp Ther. 2003 Apr;305(1):167-72.PMID: 12649365 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Liver-selective transgene rescue of hypothalamic-pituitary-adrenal axis dysfunction in 11beta-hydroxysteroid dehydrogenase type 1-deficient mice.

    Paterson JM, Holmes MC, Kenyon CJ, Carter R, Mullins JJ, Seckl JR.

    Endocrinology. 2007 Mar;148(3):961-6. Epub 2006 Dec 14.PMID: 17170103 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice.

    Makimura H, Mizuno TM, Roberts J, Silverstein J, Beasley J, Mobbs CV.

    Diabetes. 2000 Nov;49(11):1917-23.PMID: 11078460 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Sub-chronic administration of the 11beta-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity.

    Taylor A, Irwin N, McKillop AM, Flatt PR, Gault VA.

    Biol Chem. 2008 Apr;389(4):441-5.PMID: 18225986 [PubMed - indexed for MEDLINE]Related articles

    17.

    11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.

    Swali A, Walker EA, Lavery GG, Tomlinson JW, Stewart PM.

    Diabetologia. 2008 Nov;51(11):2003-11. Epub 2008 Sep 9.PMID: 18779947 [PubMed - indexed for MEDLINE]Related articles

    18.

    Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains.

    Alberts P, Nilsson C, Selen G, Engblom LO, Edling NH, Norling S, Klingström G, Larsson C, Forsgren M, Ashkzari M, Nilsson CE, Fiedler M, Bergqvist E, Ohman B, Björkstrand E, Abrahmsen LB.

    Endocrinology. 2003 Nov;144(11):4755-62. Epub 2003 Jul 31.PMID: 12960099 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Changes in glycemia by leptin administration or high- fat feeding in rodent models of obesity/type 2 diabetes suggest a link between resistin expression and control of glucose homeostasis.

    Asensio C, Cettour-Rose P, Theander-Carrillo C, Rohner-Jeanrenaud F, Muzzin P.

    Endocrinology. 2004 May;145(5):2206-13. Epub 2004 Feb 12.PMID: 14962997 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    A novel promoter for the 11beta-hydroxysteroid dehydrogenase type 1 gene is active in lung and is C/EBPalpha independent.

    Bruley C, Lyons V, Worsley AG, Wilde MD, Darlington GD, Morton NM, Seckl JR, Chapman KE.

    Endocrinology. 2006 Jun;147(6):2879-85. Epub 2006 Mar 16.PMID: 16543369 [PubMed - indexed for MEDLINE]Related articlesFree article

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