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    Results: 1 to 20 of 379

    1.

    Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes.

    Bouzakri K, Roques M, Gual P, Espinosa S, Guebre-Egziabher F, Riou JP, Laville M, Le Marchand-Brustel Y, Tanti JF, Vidal H.

    Diabetes. 2003 Jun;52(6):1319-25.PMID: 12765939 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells.

    Andreozzi F, Laratta E, Sciacqua A, Perticone F, Sesti G.

    Circ Res. 2004 May 14;94(9):1211-8. Epub 2004 Mar 25.PMID: 15044323 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients.

    Krook A, Björnholm M, Galuska D, Jiang XJ, Fahlman R, Myers MG Jr, Wallberg-Henriksson H, Zierath JR.

    Diabetes. 2000 Feb;49(2):284-92.PMID: 10868945 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Effects of streptozocin diabetes and diabetes treatment by islet transplantation on in vivo insulin signaling in rat heart.

    Laviola L, Belsanti G, Davalli AM, Napoli R, Perrini S, Weir GC, Giorgino R, Giorgino F.

    Diabetes. 2001 Dec;50(12):2709-20.PMID: 11723053 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Insulin signaling leading to proliferation, survival, and membrane ruffling in C2C12 myoblasts.

    Conejo R, Lorenzo M.

    J Cell Physiol. 2001 Apr;187(1):96-108.PMID: 11241354 [PubMed - indexed for MEDLINE]Related articles

    6.

    Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes.

    Mur C, Valverde AM, Kahn CR, Benito M.

    Diabetes. 2002 Mar;51(3):743-54.PMID: 11872675 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism.

    Miele C, Riboulet A, Maitan MA, Oriente F, Romano C, Formisano P, Giudicelli J, Beguinot F, Van Obberghen E.

    J Biol Chem. 2003 Nov 28;278(48):47376-87. Epub 2003 Sep 11.PMID: 12970360 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation.

    Björnholm M, Kawano Y, Lehtihet M, Zierath JR.

    Diabetes. 1997 Mar;46(3):524-7.PMID: 9032113 [PubMed - indexed for MEDLINE]Related articles

    9.

    Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase.

    De Fea K, Roth RA.

    J Biol Chem. 1997 Dec 12;272(50):31400-6.PMID: 9395471 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients [corrected].

    Storgaard H, Song XM, Jensen CB, Madsbad S, Björnholm M, Vaag A, Zierath JR.

    Diabetes. 2001 Dec;50(12):2770-8. Erratum in: Diabetes 2002 Feb;51(2):552. PMID: 11723060 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    TNF-alpha impairs insulin signaling and insulin stimulation of glucose uptake in C2C12 muscle cells.

    del Aguila LF, Claffey KP, Kirwan JP.

    Am J Physiol. 1999 May;276(5 Pt 1):E849-55.PMID: 10329978 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3' kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance.

    Vollenweider P, Ménard B, Nicod P.

    Diabetes. 2002 Apr;51(4):1052-9.PMID: 11916925 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    WY-14643 and 9- cis-retinoic acid induce IRS-2/PI 3-kinase signalling pathway and increase glucose transport in human skeletal muscle cells: differential effect in myotubes from healthy subjects and Type 2 diabetic patients.

    Bouzakri K, Roques M, Debard C, Berbe V, Rieusset J, Laville M, Vidal H.

    Diabetologia. 2004 Jul;47(7):1314-23. Epub 2004 Jun 26.PMID: 15292987 [PubMed - indexed for MEDLINE]Related articles

    14.

    In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents.

    Qiao LY, Zhande R, Jetton TL, Zhou G, Sun XJ.

    J Biol Chem. 2002 Jul 19;277(29):26530-9. Epub 2002 May 2.PMID: 12006586 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    GTK tyrosine kinase-induced alteration of IRS-protein signalling in insulin producing cells.

    Annerén C, Welsh M.

    Mol Med. 2002 Nov;8(11):705-13.PMID: 12520087 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes.

    Engelman JA, Berg AH, Lewis RY, Lisanti MP, Scherer PE.

    Mol Endocrinol. 2000 Oct;14(10):1557-69.PMID: 11043572 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Islet transplantation restores normal levels of insulin receptor and substrate tyrosine phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle and myocardium of streptozocin-induced diabetic rats.

    Giorgino F, Logoluso F, Davalli AM, Napoli R, Laviola L, Hirshman MF, Horton ES, Weir GC, Smith RJ.

    Diabetes. 1999 Apr;48(4):801-12.PMID: 10102697 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner.

    de Alvaro C, Teruel T, Hernandez R, Lorenzo M.

    J Biol Chem. 2004 Apr 23;279(17):17070-8. Epub 2004 Feb 4.PMID: 14764603 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle.

    Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Pratipanawatr T, DeFronzo RA, Kahn CR, Mandarino LJ.

    J Clin Invest. 2000 Feb;105(3):311-20.PMID: 10675357 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.

    Folli F, Kahn CR, Hansen H, Bouchie JL, Feener EP.

    J Clin Invest. 1997 Nov 1;100(9):2158-69.PMID: 9410892 [PubMed - indexed for MEDLINE]Related articlesFree article

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