PubMed

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

Groves CJ, Wiltshire S, Smedley D, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, O'Rahilly S, Menzel S, Hattersley AT, McCarthy MI.

Diabetes. 2003 May;52(5):1300-5.PMID: 12716770 [PubMed - indexed for MEDLINE]Related articlesFree article

High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people.

Florez JC, Wiltshire S, Agapakis CM, Burtt NP, de Bakker PI, Almgren P, Bengtsson Boström K, Tuomi T, Gaudet D, Daly MJ, Hirschhorn JN, McCarthy MI, Altshuler D, Groop L.

Diabetes. 2006 Jan;55(1):128-35.PMID: 16380485 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of polymorphisms in the insulin-degrading enzyme gene with type 2 diabetes in the Korean population.

Kwak SH, Cho YM, Moon MK, Kim JH, Park BL, Cheong HS, Shin HD, Jang HC, Kim SY, Lee HK, Park KS.

Diabetes Res Clin Pract. 2008 Feb;79(2):284-90. Epub 2007 Oct 25.PMID: 17913278 [PubMed - indexed for MEDLINE]Related articles

Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels.

Gu HF, Efendic S, Nordman S, Ostenson CG, Brismar K, Brookes AJ, Prince JA.

Diabetes. 2004 Aug;53(8):2137-42.PMID: 15277398 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese.

Bian L, Yang JD, Guo TW, Sun Y, Duan SW, Chen WY, Pan YX, Feng GY, He L.

Neurology. 2004 Jul 27;63(2):241-5.PMID: 15277615 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study.

Karamohamed S, Demissie S, Volcjak J, Liu C, Heard-Costa N, Liu J, Shoemaker CM, Panhuysen CI, Meigs JB, Wilson P, Atwood LD, Cupples LA, Herbert A; NHLBI Framingham Heart Study.

Diabetes. 2003 Jun;52(6):1562-7.PMID: 12765971 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease.

Ertekin-Taner N, Allen M, Fadale D, Scanlin L, Younkin L, Petersen RC, Graff-Radford N, Younkin SG.

Hum Mutat. 2004 Apr;23(4):334-42.PMID: 15024728 [PubMed - indexed for MEDLINE]Related articles

Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.

Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell T, Holmans P, Hamshere M, Turic D, Jehu L, Hollingworth P, Moore P, Bryden L, Myers A, Doil LM, Tacey KM, Gibson AM, McKeith IG, Perry RH, Morris CM, Thal L, Morris JC, O'Donovan MC, Lovestone S, Grupe A, Hardy J, Owen MJ, Williams J, Goate A.

Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136B(1):62-8.PMID: 15858813 [PubMed - indexed for MEDLINE]Related articles

Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.

Liew CF, Groves CJ, Wiltshire S, Zeggini E, Frayling TM, Owen KR, Walker M, Hitman GA, Levy JC, O'rahilly S, Hattersley AT, Johnston DG, McCarthy MI.

Diabetologia. 2004 Dec;47(12):2168-75. Epub 2004 Dec 15.PMID: 15662557 [PubMed - indexed for MEDLINE]Related articles

CHOP T/C and C/T haplotypes contribute to early-onset type 2 diabetes in Italians.

Gragnoli C.

J Cell Physiol. 2008 Nov;217(2):291-5.PMID: 18680108 [PubMed - indexed for MEDLINE]Related articles

Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q.

Zeggini E, Damcott CM, Hanson RL, Karim MA, Rayner NW, Groves CJ, Baier LJ, Hale TC, Hattersley AT, Hitman GA, Hunt SE, Knowler WC, Mitchell BD, Ng MC, O'Connell JR, Pollin TI, Vaxillaire M, Walker M, Wang X, Whittaker P, Xiang K, Jia W, Chan JC, Froguel P, Deloukas P, Shuldiner AR, Elbein SC, McCarthy MI; International Type 2 Diabetes 1q Consortium.

Diabetes. 2006 Sep;55(9):2541-8. Erratum in: Diabetes. 2006 Nov;55(11):3197. Kunsun, Xiang [corrected to Xiang, Kunsan]. PMID: 16936202 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.

Owen KR, Groves CJ, Hanson RL, Knowler WC, Shuldiner AR, Elbein SC, Mitchell BD, Froguel P, Ng MC, Chan JC, Jia W, Deloukas P, Hitman GA, Walker M, Frayling TM, Hattersley AT, Zeggini E, McCarthy MI.

Diabetes. 2007 Mar;56(3):879-83.PMID: 17327460 [PubMed - indexed for MEDLINE]Related articlesFree article

Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.

Abraham R, Myers A, Wavrant-DeVrieze F, Hamshere ML, Thomas HV, Marshall H, Compton D, Spurlock G, Turic D, Hoogendoorn B, Kwon JM, Petersen RC, Tangalos E, Norton J, Morris JC, Bullock R, Liolitsa D, Lovestone S, Hardy J, Goate A, O'Donovan M, Williams J, Owen MJ, Jones L.

Hum Genet. 2001 Dec;109(6):646-52. Epub 2001 Nov 1.PMID: 11810277 [PubMed - indexed for MEDLINE]Related articles

Genetic variation in a haplotype block spanning IDE influences Alzheimer disease.

Prince JA, Feuk L, Gu HF, Johansson B, Gatz M, Blennow K, Brookes AJ.

Hum Mutat. 2003 Nov;22(5):363-71.PMID: 14517947 [PubMed - indexed for MEDLINE]Related articles

Mutation screening and association of human retinoid X receptor gamma variation with lipid levels in familial type 2 diabetes.

Wang H, Chu W, Hemphill C, Hasstedt SJ, Elbein SC.

Mol Genet Metab. 2002 May;76(1):14-22.PMID: 12175776 [PubMed - indexed for MEDLINE]Related articles

Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures.

Mueller JC, Riemenschneider M, Schoepfer-Wendels A, Gohlke H, Konta L, Friedrich P, Illig T, Laws SM, Förstl H, Kurz A.

Neurobiol Aging. 2007 May;28(5):727-34. Epub 2006 May 3.PMID: 16675064 [PubMed - indexed for MEDLINE]Related articles

Evaluation of apolipoprotein A-II as a positional candidate gene for familial Type II diabetes, altered lipid concentrations, and insulin resistance.

Elbein SC, Chu W, Ren Q, Wang H, Hemphill C, Hasstedt SJ.

Diabetologia. 2002 Jul;45(7):1026-33. Epub 2002 May 8.PMID: 12136402 [PubMed - indexed for MEDLINE]Related articles

Association of common variation in the HNF1alpha gene region with risk of type 2 diabetes.

Winckler W, Burtt NP, Holmkvist J, Cervin C, de Bakker PI, Sun M, Almgren P, Tuomi T, Gaudet D, Hudson TJ, Ardlie KG, Daly MJ, Hirschhorn JN, Altshuler D, Groop L.

Diabetes. 2005 Aug;54(8):2336-42.PMID: 16046299 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population.

Furukawa Y, Shimada T, Furuta H, Matsuno S, Kusuyama A, Doi A, Nishi M, Sasaki H, Sanke T, Nanjo K.

J Clin Endocrinol Metab. 2008 Jan;93(1):310-4. Epub 2007 Oct 30.PMID: 17971426 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variation and association analyses of the nuclear respiratory factor 1 (nRF1) gene in Chinese patients with type 2 diabetes.

Liu Y, Niu N, Zhu X, Du T, Wang X, Chen D, Wu X, Gu HF, Liu Y.

Diabetes. 2008 Mar;57(3):777-82. Epub 2007 Dec 10.PMID: 18071027 [PubMed - indexed for MEDLINE]Related articlesFree article