PubMed

Overexpression of PACAP in transgenic mouse pancreatic beta-cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes.

Yamamoto K, Hashimoto H, Tomimoto S, Shintani N, Miyazaki J, Tashiro F, Aihara H, Nammo T, Li M, Yamagata K, Miyagawa J, Matsuzawa Y, Kawabata Y, Fukuyama Y, Koga K, Mori W, Tanaka K, Matsuda T, Baba A.

Diabetes. 2003 May;52(5):1155-62.PMID: 12716746 [PubMed - indexed for MEDLINE]Related articlesFree article

[Transgenic mice overexpressing PACAP in pancreatic beta-cells: acute and chronic effects on insulin and glucose homeostasis]

Tomimoto S, Hashimoto H, Shintani N, Baba A.

Nippon Yakurigaku Zasshi. 2004 Apr;123(4):261-6. Review. Japanese. PMID: 15056941 [PubMed - indexed for MEDLINE]Related articles

Systemic administration of pituitary adenylate cyclase-activating polypeptide maintains beta-cell mass and retards onset of hyperglycaemia in beta-cell-specific calmodulin-overexpressing transgenic mice.

Tsunekawa S, Miura Y, Yamamoto N, Itoh Y, Ariyoshi Y, Senda T, Oiso Y, Niki I.

Eur J Endocrinol. 2005 May;152(5):805-11.PMID: 15879367 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic mice expressing Shb adaptor protein under the control of rat insulin promoter exhibit altered viability of pancreatic islet cells.

Welsh M, Christmansson L, Karlsson T, Sandler S, Welsh N.

Mol Med. 1999 Mar;5(3):169-80.PMID: 10404514 [PubMed - indexed for MEDLINE]Related articlesFree article

Pituitary adenylate cyclase-activating polypeptide (PACAP) is an islet substance serving as an intra-islet amplifier of glucose-induced insulin secretion in rats.

Yada T, Sakurada M, Ishihara H, Nakata M, Shioda S, Yaekura K, Hamakawa N, Yanagida K, Kikuchi M, Oka Y.

J Physiol. 1997 Dec 1;505 ( Pt 2):319-28.PMID: 9423175 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice.

Iwakura H, Hosoda K, Son C, Fujikura J, Tomita T, Noguchi M, Ariyasu H, Takaya K, Masuzaki H, Ogawa Y, Hayashi T, Inoue G, Akamizu T, Hosoda H, Kojima M, Itoh H, Toyokuni S, Kangawa K, Nakao K.

J Biol Chem. 2005 Apr 15;280(15):15247-56. Epub 2005 Feb 8.PMID: 15701644 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.

Nagasumi K, Esaki R, Iwachidow K, Yasuhara Y, Ogi K, Tanaka H, Nakata M, Yano T, Shimakawa K, Taketomi S, Takeuchi K, Odaka H, Kaisho Y.

Diabetes. 2009 May;58(5):1067-76. Erratum in: Diabetes. 2009 Jul;58(7):1721. PMID: 19401434 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of pituitary adenylate cyclase-activating polypeptide in islet transplantation.

Sakuma Y, Ricordi C, Miki A, Yamamoto T, Mita A, Barker S, Damaris RM, Pileggi A, Yasuda Y, Yada T, Ichii H.

Transplant Proc. 2009 Jan-Feb;41(1):343-5.PMID: 19249552 [PubMed - indexed for MEDLINE]Related articles

Molecular and functional characterization of pituitary adenylate cyclase-activating polypeptide (PACAP-38)/vasoactive intestinal polypeptide receptors in pancreatic beta-cells and effects of PACAP-38 on components of the insulin secretory system.

Borboni P, Porzio O, Pierucci D, Cicconi S, Magnaterra R, Federici M, Sesti G, Lauro D, D'Agata V, Cavallaro S, Marlier LN.

Endocrinology. 1999 Dec;140(12):5530-7.PMID: 10579316 [PubMed - indexed for MEDLINE]Related articlesFree article

Current status of PACAP as a regulator of insulin secretion in pancreatic islets.

Yada T, Sakurada M, Nakata M, Ihida K, Yaekura K, Shioda S, Kikuchi M.

Ann N Y Acad Sci. 1996 Dec 26;805:329-40; discussion 341-2.PMID: 8993414 [PubMed - indexed for MEDLINE]Related articles

Functional roles of the neuropeptide PACAP in brain and pancreas.

Shintani N, Tomimoto S, Hashimoto H, Kawaguchi C, Baba A.

Life Sci. 2003 Dec 5;74(2-3):337-43.PMID: 14607262 [PubMed - indexed for MEDLINE]Related articles

Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in vivo.

Kato I, Suzuki Y, Akabane A, Yonekura H, Tanaka O, Kondo H, Takasawa S, Yoshimoto T, Okamoto H.

J Biol Chem. 1994 Aug 19;269(33):21223-8.PMID: 8063743 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo proliferation of differentiated pancreatic islet beta cells in transgenic mice expressing mutated cyclin-dependent kinase 4.

Hino S, Yamaoka T, Yamashita Y, Yamada T, Hata J, Itakura M.

Diabetologia. 2004 Oct;47(10):1819-30. Epub 2004 Oct 6.PMID: 15480536 [PubMed - indexed for MEDLINE]Related articles

Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes.

Laybutt DR, Weir GC, Kaneto H, Lebet J, Palmiter RD, Sharma A, Bonner-Weir S.

Diabetes. 2002 Jun;51(6):1793-804.PMID: 12031967 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia.

Garcia-Ocaña A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF.

J Biol Chem. 2000 Jan 14;275(2):1226-32.PMID: 10625667 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.

Devedjian JC, George M, Casellas A, Pujol A, Visa J, Pelegrín M, Gros L, Bosch F.

J Clin Invest. 2000 Mar;105(6):731-40.PMID: 10727441 [PubMed - indexed for MEDLINE]Related articlesFree article

Very-low-dose streptozotocin induces diabetes in insulin promoter-mB7-1 transgenic mice.

Harlan DM, Barnett MA, Abe R, Pechhold K, Patterson NB, Gray GS, June CH.

Diabetes. 1995 Jul;44(7):816-23.PMID: 7540575 [PubMed - indexed for MEDLINE]Related articles

Enhancement of glucose-induced insulin secretion in transgenic mice overexpressing human VIP gene in pancreatic beta cells.

Kato I, Suzuki Y, Akabane A, Yonekura H, Tanaka O, Kondo H, Takasawa S, Yoshimoto T, Okamoto H.

Ann N Y Acad Sci. 1996 Dec 26;805:232-42; discussion 242-3. Review.PMID: 8993406 [PubMed - indexed for MEDLINE]Related articles

Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells.

Yada T, Sakurada M, Ihida K, Nakata M, Murata F, Arimura A, Kikuchi M.

J Biol Chem. 1994 Jan 14;269(2):1290-3.PMID: 8288592 [PubMed - indexed for MEDLINE]Related articlesFree article

Pituitary adenylate cyclase-activating polypeptide (PACAP): occurrence in rodent pancreas and effects on insulin and glucagon secretion in the mouse.

Fridolf T, Sundler F, Ahrén B.

Cell Tissue Res. 1992 Aug;269(2):275-9.PMID: 1423494 [PubMed - indexed for MEDLINE]Related articles