PubMed

Hepatic VLDL production in ob/ob mice is not stimulated by massive de novo lipogenesis but is less sensitive to the suppressive effects of insulin.

Wiegman CH, Bandsma RH, Ouwens M, van der Sluijs FH, Havinga R, Boer T, Reijngoud DJ, Romijn JA, Kuipers F.

Diabetes. 2003 May;52(5):1081-9.PMID: 12716736 [PubMed - indexed for MEDLINE]Related articlesFree article

ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice.

Chen Z, Newberry EP, Norris JY, Xie Y, Luo J, Kennedy SM, Davidson NO.

J Lipid Res. 2008 Sep;49(9):2013-22. Epub 2008 Jun 2.PMID: 18519977 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of plasma free fatty acids on lipoprotein synthesis and diabetic dyslipidemia.

Julius U.

Exp Clin Endocrinol Diabetes. 2003 Aug;111(5):246-50. Review.PMID: 12951628 [PubMed - indexed for MEDLINE]Related articles

Apolipoprotein B mRNA editing and apolipoprotein gene expression in the liver of hyperinsulinemic fatty Zucker rats: relationship to very low density lipoprotein composition.

Elam MB, von Wronski MA, Cagen L, Thorngate F, Kumar P, Heimberg M, Wilcox HG.

Lipids. 1999 Aug;34(8):809-16.PMID: 10529091 [PubMed - indexed for MEDLINE]Related articles

Acute inhibition of glucose-6-phosphate translocator activity leads to increased de novo lipogenesis and development of hepatic steatosis without affecting VLDL production in rats.

Bandsma RH, Wiegman CH, Herling AW, Burger HJ, ter Harmsel A, Meijer AJ, Romijn JA, Reijngoud DJ, Kuipers F.

Diabetes. 2001 Nov;50(11):2591-7.PMID: 11679439 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor-alpha directly stimulates the overproduction of hepatic apolipoprotein B100-containing VLDL via impairment of hepatic insulin signaling.

Qin B, Anderson RA, Adeli K.

Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1120-9. Epub 2008 Mar 27.PMID: 18372392 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice.

Grefhorst A, van Dijk TH, Hammer A, van der Sluijs FH, Havinga R, Havekes LM, Romijn JA, Groot PH, Reijngoud DJ, Kuipers F.

Am J Physiol Endocrinol Metab. 2005 Nov;289(5):E829-38. Epub 2005 Jun 7.PMID: 15941783 [PubMed - indexed for MEDLINE]Related articlesFree article

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice.

Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, Farese RV Jr, Horton JD, Preitner F, Thorens B, Tappy L.

J Lipid Res. 2008 Sep;49(9):2038-44. Epub 2008 Jun 1.PMID: 18515909 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor alpha.

van der Veen JN, Havinga R, Bloks VW, Groen AK, Kuipers F.

J Lipid Res. 2007 Feb;48(2):337-47. Epub 2006 Nov 4.PMID: 17088263 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice.

López-Parra M, Titos E, Horrillo R, Ferré N, González-Périz A, Martínez-Clemente M, Planagumà A, Masferrer J, Arroyo V, Clària J.

J Lipid Res. 2008 Dec;49(12):2513-23. Epub 2008 Jul 21.PMID: 18645210 [PubMed - indexed for MEDLINE]Related articles

Leptin augments the acute suppressive effects of insulin on hepatic very low-density lipoprotein production in rats.

Huang W, Metlakunta A, Dedousis N, Ortmeyer HK, Stefanovic-Racic M, O'Doherty RM.

Endocrinology. 2009 May;150(5):2169-74. Epub 2009 Jan 15.PMID: 19147673 [PubMed - indexed for MEDLINE]Related articles

Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.

Qiu W, Federico L, Naples M, Avramoglu RK, Meshkani R, Zhang J, Tsai J, Hussain M, Dai K, Iqbal J, Kontos CD, Horie Y, Suzuki A, Adeli K.

Hepatology. 2008 Dec;48(6):1799-809.PMID: 19026012 [PubMed - indexed for MEDLINE]Related articles

Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice.

Han S, Liang CP, Westerterp M, Senokuchi T, Welch CL, Wang Q, Matsumoto M, Accili D, Tall AR.

J Clin Invest. 2009 Apr;119(4):1029-41. doi: 10.1172/JCI36523. Epub 2009 Mar 9.PMID: 19273907 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic apolipoprotein E expression promotes very low density lipoprotein-apolipoprotein B production in vivo in mice.

Maugeais C, Tietge UJ, Tsukamoto K, Glick JM, Rader DJ.

J Lipid Res. 2000 Oct;41(10):1673-9.PMID: 11013310 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of plasma triglycerides in insulin resistance and diabetes.

Ginsberg HN, Zhang YL, Hernandez-Ono A.

Arch Med Res. 2005 May-Jun;36(3):232-40. Review.PMID: 15925013 [PubMed - indexed for MEDLINE]Related articles

Increased production of very-low-density lipoproteins in transgenic mice overexpressing human apolipoprotein A-II and fed with a high-fat diet.

Julve J, Escolà-Gil JC, Marzal-Casacuberta A, Ordóñez-Llanos J, González-Sastre F, Blanco-Vaca F.

Biochim Biophys Acta. 2000 Nov 15;1488(3):233-44.PMID: 11082533 [PubMed - indexed for MEDLINE]Related articles

Metabolic adaptations to dietary fat malabsorption in chylomicron-deficient mice.

Jung HR, Turner SM, Neese RA, Young SG, Hellerstein MK.

Biochem J. 1999 Oct 15;343 Pt 2:473-8.PMID: 10510316 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholesterol 7alpha-hydroxylase deficiency in mice on an APOE*3-Leiden background impairs very-low-density lipoprotein production.

Post SM, Groenendijk M, Solaas K, Rensen PC, Princen HM.

Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):768-74. Epub 2004 Feb 12.PMID: 14962946 [PubMed - indexed for MEDLINE]Related articlesFree article

Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production.

Millar JS, Stone SJ, Tietge UJ, Tow B, Billheimer JT, Wong JS, Hamilton RL, Farese RV Jr, Rader DJ.

J Lipid Res. 2006 Oct;47(10):2297-305. Epub 2006 Jul 30.PMID: 16877777 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.

Dentin R, Benhamed F, Hainault I, Fauveau V, Foufelle F, Dyck JR, Girard J, Postic C.

Diabetes. 2006 Aug;55(8):2159-70.PMID: 16873678 [PubMed - indexed for MEDLINE]Related articlesFree article