PubMed

5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes.

Koistinen HA, Galuska D, Chibalin AV, Yang J, Zierath JR, Holman GD, Wallberg-Henriksson H.

Diabetes. 2003 May;52(5):1066-72.PMID: 12716734 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner.

Buhl ES, Jessen N, Schmitz O, Pedersen SB, Pedersen O, Holman GD, Lund S.

Diabetes. 2001 Jan;50(1):12-7.PMID: 11147776 [PubMed - indexed for MEDLINE]Related articlesFree article

Sending the signal: molecular mechanisms regulating glucose uptake.

Krook A, Wallberg-Henriksson H, Zierath JR.

Med Sci Sports Exerc. 2004 Jul;36(7):1212-7. Review.PMID: 15235328 [PubMed - indexed for MEDLINE]Related articles

The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle.

Lemieux K, Konrad D, Klip A, Marette A.

FASEB J. 2003 Sep;17(12):1658-65.PMID: 12958172 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle.

Li J, Hu X, Selvakumar P, Russell RR 3rd, Cushman SW, Holman GD, Young LH.

Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E834-41. Epub 2004 Jul 20.PMID: 15265762 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles.

Jessen N, Pold R, Buhl ES, Jensen LS, Schmitz O, Lund S.

J Appl Physiol. 2003 Apr;94(4):1373-9. Epub 2002 Dec 20.PMID: 12496137 [PubMed - indexed for MEDLINE]Related articlesFree article

alpha2 Isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-d-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle.

Nakano M, Hamada T, Hayashi T, Yonemitsu S, Miyamoto L, Toyoda T, Tanaka S, Masuzaki H, Ebihara K, Ogawa Y, Hosoda K, Inoue G, Yoshimasa Y, Otaka A, Fushiki T, Nakao K.

Metabolism. 2006 Mar;55(3):300-8.PMID: 16483872 [PubMed - indexed for MEDLINE]Related articles

Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status.

Babraj JA, Mustard K, Sutherland C, Towler MC, Chen S, Smith K, Green K, Leese G, Hardie DG, Rennie MJ, Cuthbertson DJ.

Am J Physiol Endocrinol Metab. 2009 May;296(5):E1042-8. Epub 2009 Feb 3.PMID: 19190259 [PubMed - indexed for MEDLINE]Related articles

Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats.

Bergeron R, Previs SF, Cline GW, Perret P, Russell RR 3rd, Young LH, Shulman GI.

Diabetes. 2001 May;50(5):1076-82.PMID: 11334411 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM.

Zierath JR, He L, Gumà A, Odegoard Wahlström E, Klip A, Wallberg-Henriksson H.

Diabetologia. 1996 Oct;39(10):1180-9.PMID: 8897005 [PubMed - indexed for MEDLINE]Related articles

5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle.

Kurth-Kraczek EJ, Hirshman MF, Goodyear LJ, Winder WW.

Diabetes. 1999 Aug;48(8):1667-71.PMID: 10426389 [PubMed - indexed for MEDLINE]Related articlesFree article

Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes.

Yamaguchi S, Katahira H, Ozawa S, Nakamichi Y, Tanaka T, Shimoyama T, Takahashi K, Yoshimoto K, Imaizumi MO, Nagamatsu S, Ishida H.

Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E643-9. Epub 2005 May 31.PMID: 15928020 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients.

Ryder JW, Yang J, Galuska D, Rincón J, Björnholm M, Krook A, Lund S, Pedersen O, Wallberg-Henriksson H, Zierath JR, Holman GD.

Diabetes. 2000 Apr;49(4):647-54.PMID: 10871204 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute and chronic treatment of ob/ob and db/db mice with AICAR decreases blood glucose concentrations.

Halseth AE, Ensor NJ, White TA, Ross SA, Gulve EA.

Biochem Biophys Res Commun. 2002 Jun 21;294(4):798-805.PMID: 12061777 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase: possible target for treatment of type 2 diabetes.

Winder WW.

Diabetes Technol Ther. 2000 Autumn;2(3):441-8. Review.PMID: 11467346 [PubMed - indexed for MEDLINE]Related articles

Effect of fiber type and nutritional state on AICAR- and contraction-stimulated glucose transport in rat muscle.

Ai H, Ihlemann J, Hellsten Y, Lauritzen HP, Hardie DG, Galbo H, Ploug T.

Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1291-300.PMID: 12006359 [PubMed - indexed for MEDLINE]Related articlesFree article

Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle.

Taylor EB, An D, Kramer HF, Yu H, Fujii NL, Roeckl KS, Bowles N, Hirshman MF, Xie J, Feener EP, Goodyear LJ.

J Biol Chem. 2008 Apr 11;283(15):9787-96. Epub 2008 Feb 13.PMID: 18276596 [PubMed - indexed for MEDLINE]Related articlesFree article

Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients.

Boon H, Bosselaar M, Praet SF, Blaak EE, Saris WH, Wagenmakers AJ, McGee SL, Tack CJ, Smits P, Hargreaves M, van Loon LJ.

Diabetologia. 2008 Oct;51(10):1893-900. Epub 2008 Aug 16.PMID: 18709353 [PubMed - indexed for MEDLINE]Related articles

Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport.

Hayashi T, Hirshman MF, Kurth EJ, Winder WW, Goodyear LJ.

Diabetes. 1998 Aug;47(8):1369-73.PMID: 9703344 [PubMed - indexed for MEDLINE]Related articlesFree article

Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation.

Jørgensen SB, Honeyman J, Oakhill JS, Fazakerley D, Stöckli J, Kemp BE, Steinberg GR.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E57-66. Epub 2009 May 12.PMID: 19435854 [PubMed - indexed for MEDLINE]Related articles