PubMed

Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin.

Kohno D, Gao HZ, Muroya S, Kikuyama S, Yada T.

Diabetes. 2003 Apr;52(4):948-56.PMID: 12663466 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway.

Kohno D, Nakata M, Maekawa F, Fujiwara K, Maejima Y, Kuramochi M, Shimazaki T, Okano H, Onaka T, Yada T.

Endocrinology. 2007 May;148(5):2251-63. Epub 2007 Feb 15.PMID: 17303662 [PubMed - indexed for MEDLINE]Related articlesFree article

Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus.

Muroya S, Funahashi H, Yamanaka A, Kohno D, Uramura K, Nambu T, Shibahara M, Kuramochi M, Takigawa M, Yanagisawa M, Sakurai T, Shioda S, Yada T.

Eur J Neurosci. 2004 Mar;19(6):1524-34.PMID: 15066149 [PubMed - indexed for MEDLINE]Related articles

Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons.

Kohno D, Sone H, Minokoshi Y, Yada T.

Biochem Biophys Res Commun. 2008 Feb 8;366(2):388-92. Epub 2007 Dec 7.PMID: 18068666 [PubMed - indexed for MEDLINE]Related articles

Leptin transiently antagonizes ghrelin and long-lastingly orexin in regulation of Ca2+ signaling in neuropeptide Y neurons of the arcuate nucleus.

Kohno D, Suyama S, Yada T.

World J Gastroenterol. 2008 Nov 7;14(41):6347-54.PMID: 19009650 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin regulated calcium channels of neuropeptide Y and proopiomelanocortin neurons by activation of different signal pathways.

Wang JH, Wang F, Yang MJ, Yu DF, Wu WN, Liu J, Ma LQ, Cai F, Chen JG.

Neuroscience. 2008 Sep 22;156(1):89-98. Epub 2008 Jun 5.PMID: 18588949 [PubMed - indexed for MEDLINE]Related articles

Galanin-like peptide and ghrelin increase cytosolic Ca2+ in neurons containing growth hormone-releasing hormone in the arcuate nucleus.

Kuramochi M, Kohno D, Onaka T, Kato S, Yada T.

Regul Pept. 2005 Mar 15;126(1-2):85-9.PMID: 15620419 [PubMed - indexed for MEDLINE]Related articles

Ghrelin increases neuropeptide Y and agouti-related peptide gene expression in the arcuate nucleus in rat hypothalamic organotypic cultures.

Goto M, Arima H, Watanabe M, Hayashi M, Banno R, Sato I, Nagasaki H, Oiso Y.

Endocrinology. 2006 Nov;147(11):5102-9. Epub 2006 Aug 3.PMID: 16887908 [PubMed - indexed for MEDLINE]Related articlesFree article

Basomedial hypothalamic injections of neuropeptide Y conjugated to saporin selectively disrupt hypothalamic controls of food intake.

Bugarith K, Dinh TT, Li AJ, Speth RC, Ritter S.

Endocrinology. 2005 Mar;146(3):1179-91. Epub 2004 Dec 16.PMID: 15604214 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y.

Muroya S, Yada T, Shioda S, Takigawa M.

Neurosci Lett. 1999 Apr 2;264(1-3):113-6.PMID: 10320027 [PubMed - indexed for MEDLINE]Related articles

Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor.

Toshinai K, Yamaguchi H, Sun Y, Smith RG, Yamanaka A, Sakurai T, Date Y, Mondal MS, Shimbara T, Kawagoe T, Murakami N, Miyazato M, Kangawa K, Nakazato M.

Endocrinology. 2006 May;147(5):2306-14. Epub 2006 Feb 16.PMID: 16484324 [PubMed - indexed for MEDLINE]Related articlesFree article

Orexin-A augments voltage-gated Ca2+ currents and synergistically increases growth hormone (GH) secretion with GH-releasing hormone in primary cultured ovine somatotropes.

Xu R, Wang Q, Yan M, Hernandez M, Gong C, Boon WC, Murata Y, Ueta Y, Chen C.

Endocrinology. 2002 Dec;143(12):4609-19.PMID: 12446588 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling.

Morrison CD, Morton GJ, Niswender KD, Gelling RW, Schwartz MW.

Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1051-7. Epub 2005 Jul 26.PMID: 16046456 [PubMed - indexed for MEDLINE]Related articlesFree article

Site-specific effects of ghrelin on the neuronal activity in the hypothalamic arcuate nucleus.

Riediger T, Traebert M, Schmid HA, Scheel C, Lutz TA, Scharrer E.

Neurosci Lett. 2003 May 1;341(2):151-5.PMID: 12686388 [PubMed - indexed for MEDLINE]Related articles

Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway.

Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K, Hayashi T, Inoue G, Hosoda K, Kojima M, Kangawa K, Nakao K.

Diabetes. 2001 Feb;50(2):227-32.PMID: 11272130 [PubMed - indexed for MEDLINE]Related articlesFree article

Downregulation of fasting-induced cAMP response element-mediated gene induction by leptin in neuropeptide Y neurons of the arcuate nucleus.

Shimizu-Albergine M, Ippolito DL, Beavo JA.

J Neurosci. 2001 Feb 15;21(4):1238-46.PMID: 11160394 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of methamphetamine on expression of neuropeptide Y mRNA in hypothalamus and on serum leptin and ghrelin concentrations in ad libitum-fed and schedule-fed rats.

Crowley WR, Ramoz G, Keefe KA, Torto R, Kalra SP, Hanson GR.

Neuroscience. 2005;132(1):167-73.PMID: 15780475 [PubMed - indexed for MEDLINE]Related articles

PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus.

Nakata M, Kohno D, Shintani N, Nemoto Y, Hashimoto H, Baba A, Yada T.

Neurosci Lett. 2004 Nov 11;370(2-3):252-6.PMID: 15488333 [PubMed - indexed for MEDLINE]Related articles

Ghrelin-induced food intake is mediated via the orexin pathway.

Toshinai K, Date Y, Murakami N, Shimada M, Mondal MS, Shimbara T, Guan JL, Wang QP, Funahashi H, Sakurai T, Shioda S, Matsukura S, Kangawa K, Nakazato M.

Endocrinology. 2003 Apr;144(4):1506-12.PMID: 12639935 [PubMed - indexed for MEDLINE]Related articlesFree article

Orexin-a activates phospholipase C- and protein kinase C-mediated Ca2+ signaling in dopamine neurons of the ventral tegmental area.

Uramura K, Funahashi H, Muroya S, Shioda S, Takigawa M, Yada T.

Neuroreport. 2001 Jul 3;12(9):1885-9.PMID: 11435917 [PubMed - indexed for MEDLINE]Related articles