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    Results: 1 to 20 of 181

    1.

    Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance.

    Brozinick JT Jr, Roberts BR, Dohm GL.

    Diabetes. 2003 Apr;52(4):935-41.PMID: 12663464 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

    Kim YB, Zhu JS, Zierath JR, Shen HQ, Baron AD, Kahn BB.

    Diabetes. 1999 Feb;48(2):310-20.PMID: 10334307 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation.

    Kruszynska YT, Worrall DS, Ofrecio J, Frias JP, Macaraeg G, Olefsky JM.

    J Clin Endocrinol Metab. 2002 Jan;87(1):226-34.PMID: 11788651 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle.

    Dokken BB, Sloniger JA, Henriksen EJ.

    Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1188-94. Epub 2005 Jan 25.PMID: 15671078 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats.

    Kim YB, Peroni OD, Franke TF, Kahn BB.

    Diabetes. 2000 May;49(5):847-56.PMID: 10905496 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism.

    Miele C, Riboulet A, Maitan MA, Oriente F, Romano C, Formisano P, Giudicelli J, Beguinot F, Van Obberghen E.

    J Biol Chem. 2003 Nov 28;278(48):47376-87. Epub 2003 Sep 11.PMID: 12970360 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes.

    Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB.

    J Clin Invest. 1999 Sep;104(6):733-41.PMID: 10491408 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Evidence against a role for insulin-signaling proteins PI 3-kinase and Akt in insulin resistance in human skeletal muscle induced by short-term GH infusion.

    Jessen N, Djurhuus CB, Jørgensen JO, Jensen LS, Møller N, Lund S, Schmitz O.

    Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E194-9. Epub 2004 Aug 31.PMID: 15339744 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Growth hormone induces cellular insulin resistance by uncoupling phosphatidylinositol 3-kinase and its downstream signals in 3T3-L1 adipocytes.

    Takano A, Haruta T, Iwata M, Usui I, Uno T, Kawahara J, Ueno E, Sasaoka T, Kobayashi M.

    Diabetes. 2001 Aug;50(8):1891-900.PMID: 11473053 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Impaired activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 in cultured preadipocyte-derived adipocytes and myotubes of obese subjects.

    Sajan MP, Standaert ML, Miura A, Bandyopadhyay G, Vollenweider P, Franklin DM, Lea-Currie R, Farese RV.

    J Clin Endocrinol Metab. 2004 Aug;89(8):3994-8.PMID: 15292339 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Epidermal growth factor and transforming growth factor alpha mimic the effects of insulin in human fat cells and augment downstream signaling in insulin resistance.

    Gogg S, Smith U.

    J Biol Chem. 2002 Sep 27;277(39):36045-51. Epub 2002 Jul 22.PMID: 12138086 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats.

    Ogihara T, Asano T, Ando K, Chiba Y, Sekine N, Sakoda H, Anai M, Onishi Y, Fujishiro M, Ono H, Shojima N, Inukai K, Fukushima Y, Kikuchi M, Fujita T.

    Diabetes. 2001 Mar;50(3):573-83.PMID: 11246877 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction.

    Kim YB, Kotani K, Ciaraldi TP, Henry RR, Kahn BB.

    Diabetes. 2003 Aug;52(8):1935-42.PMID: 12882908 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

    Khamzina L, Veilleux A, Bergeron S, Marette A.

    Endocrinology. 2005 Mar;146(3):1473-81. Epub 2004 Dec 16.PMID: 15604215 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients [corrected].

    Storgaard H, Song XM, Jensen CB, Madsbad S, Björnholm M, Vaag A, Zierath JR.

    Diabetes. 2001 Dec;50(12):2770-8. Erratum in: Diabetes 2002 Feb;51(2):552. PMID: 11723060 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle.

    Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM.

    Diabetes. 2005 Aug;54(8):2351-9.PMID: 16046301 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes.

    Sasaoka T, Hori H, Wada T, Ishiki M, Haruta T, Ishihara H, Kobayashi M.

    Diabetologia. 2001 Oct;44(10):1258-67.PMID: 11692174 [PubMed - indexed for MEDLINE]Related articles

    18.

    Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells.

    Batty IH, Fleming IN, Downes CP.

    Biochem J. 2004 May 1;379(Pt 3):641-51.PMID: 14769130 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle.

    Kurowski TG, Lin Y, Luo Z, Tsichlis PN, Buse MG, Heydrick SJ, Ruderman NB.

    Diabetes. 1999 Mar;48(3):658-63.PMID: 10078574 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle.

    Brozinick JT Jr, Birnbaum MJ.

    J Biol Chem. 1998 Jun 12;273(24):14679-82.PMID: 9614064 [PubMed - indexed for MEDLINE]Related articlesFree article

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