PubMed

Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation.

Abiko T, Abiko A, Clermont AC, Shoelson B, Horio N, Takahashi J, Adamis AP, King GL, Bursell SE.

Diabetes. 2003 Mar;52(3):829-37.PMID: 12606527 [PubMed - indexed for MEDLINE]Related articlesFree article

Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats.

Bursell SE, Takagi C, Clermont AC, Takagi H, Mori F, Ishii H, King GL.

Invest Ophthalmol Vis Sci. 1997 Dec;38(13):2711-20.PMID: 9418723 [PubMed - indexed for MEDLINE]Related articlesFree article

PKC-beta inhibitor (LY333531) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats.

Nonaka A, Kiryu J, Tsujikawa A, Yamashiro K, Miyamoto K, Nishiwaki H, Honda Y, Ogura Y.

Invest Ophthalmol Vis Sci. 2000 Aug;41(9):2702-6.PMID: 10937586 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of diabetes-induced abnormal retinal blood flow by treatment with d-alpha-tocopherol.

Kunisaki M, Bursell SE, Umeda F, Nawata H, King GL.

Biofactors. 1998;7(1-2):55-67.PMID: 9523029 [PubMed - indexed for MEDLINE]Related articles

Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway.

Kunisaki M, Bursell SE, Clermont AC, Ishii H, Ballas LM, Jirousek MR, Umeda F, Nawata H, King GL.

Am J Physiol. 1995 Aug;269(2 Pt 1):E239-46.PMID: 7653541 [PubMed - indexed for MEDLINE]Related articles

Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats.

Kowluru RA, Odenbach S.

Diabetes. 2004 Dec;53(12):3233-8.PMID: 15561955 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes.

Yokota T, Ma RC, Park JY, Isshiki K, Sotiropoulos KB, Rauniyar RK, Bornfeldt KE, King GL.

Diabetes. 2003 Mar;52(3):838-45.PMID: 12606528 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathogenetic potential of leukocytes in diabetic retinopathy.

Miyamoto K, Ogura Y.

Semin Ophthalmol. 1999 Dec;14(4):233-9. Review.PMID: 10758224 [PubMed - indexed for MEDLINE]Related articles

Effects of protein kinase Cbeta inhibition on neurovascular dysfunction in diabetic rats: interaction with oxidative stress and essential fatty acid dysmetabolism.

Cameron NE, Cotter MA.

Diabetes Metab Res Rev. 2002 Jul-Aug;18(4):315-23.PMID: 12203947 [PubMed - indexed for MEDLINE]Related articles

Diabetes-induced elevations in retinal oxidative stress, protein kinase C and nitric oxide are interrelated.

Kowluru RA.

Acta Diabetol. 2001 Dec;38(4):179-85.PMID: 11855796 [PubMed - indexed for MEDLINE]Related articles

Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy.

Leal EC, Manivannan A, Hosoya K, Terasaki T, Cunha-Vaz J, Ambrósio AF, Forrester JV.

Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5257-65.PMID: 17962481 [PubMed - indexed for MEDLINE]Related articlesFree article

Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation.

Shiba T, Inoguchi T, Sportsman JR, Heath WF, Bursell S, King GL.

Am J Physiol. 1993 Nov;265(5 Pt 1):E783-93.PMID: 8238505 [PubMed - indexed for MEDLINE]Related articles

Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy.

Lin J, Bierhaus A, Bugert P, Dietrich N, Feng Y, Vom Hagen F, Nawroth P, Brownlee M, Hammes HP.

Diabetologia. 2006 May;49(5):1089-96. Epub 2006 Mar 7.PMID: 16520919 [PubMed - indexed for MEDLINE]Related articles

Effects of antioxidant treatment on normal and diabetic rat retinal enzyme activities.

Dene BA, Maritim AC, Sanders RA, Watkins JB 3rd.

J Ocul Pharmacol Ther. 2005 Feb;21(1):28-35.PMID: 15718825 [PubMed - indexed for MEDLINE]Related articles

Abnormalities of retinal metabolism in diabetes or experimental galactosemia: V. Relationship between protein kinase C and ATPases.

Kowluru RA, Jirousek MR, Stramm L, Farid N, Engerman RL, Kern TS.

Diabetes. 1998 Mar;47(3):464-9.PMID: 9519755 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of alpha 4 integrin (CD49d) in the pathogenesis of diabetic retinopathy.

Iliaki E, Poulaki V, Mitsiades N, Mitsiades CS, Miller JW, Gragoudas ES.

Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4898-904. Epub 2009 Jun 24.PMID: 19553613 [PubMed - indexed for MEDLINE]Related articles

The role of protein kinase C activation and the vascular complications of diabetes.

Das Evcimen N, King GL.

Pharmacol Res. 2007 Jun;55(6):498-510. Epub 2007 May 5. Review.PMID: 17574431 [PubMed - indexed for MEDLINE]Related articles

VEGF164 is proinflammatory in the diabetic retina.

Ishida S, Usui T, Yamashiro K, Kaji Y, Ahmed E, Carrasquillo KG, Amano S, Hida T, Oguchi Y, Adamis AP.

Invest Ophthalmol Vis Sci. 2003 May;44(5):2155-62.PMID: 12714656 [PubMed - indexed for MEDLINE]Related articlesFree article

Blood-retinal barrier breakdown induced by activation of protein kinase C via vascular endothelial growth factor in streptozotocin-induced diabetic rats.

Xu X, Zhu Q, Xia X, Zhang S, Gu Q, Luo D.

Curr Eye Res. 2004 Apr;28(4):251-6.PMID: 15259294 [PubMed - indexed for MEDLINE]Related articles

Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes.

Barouch FC, Miyamoto K, Allport JR, Fujita K, Bursell SE, Aiello LP, Luscinskas FW, Adamis AP.

Invest Ophthalmol Vis Sci. 2000 Apr;41(5):1153-8.PMID: 10752954 [PubMed - indexed for MEDLINE]Related articlesFree article