PubMed

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function.

Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY.

Diabetes. 2003 Mar;52(3):726-33.PMID: 12606514 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function.

Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY.

Diabetes. 2001 Jan;50(1):69-76.PMID: 11147797 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

Piro S, Anello M, Di Pietro C, Lizzio MN, Patanè G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F.

Metabolism. 2002 Oct;51(10):1340-7.PMID: 12370856 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.

Maestre I, Jordán J, Calvo S, Reig JA, Ceña V, Soria B, Prentki M, Roche E.

Endocrinology. 2003 Jan;144(1):335-45.PMID: 12488362 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes.

Dyntar D, Eppenberger-Eberhardt M, Maedler K, Pruschy M, Eppenberger HM, Spinas GA, Donath MY.

Diabetes. 2001 Sep;50(9):2105-13.PMID: 11522678 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1.

Rakatzi I, Mueller H, Ritzeler O, Tennagels N, Eckel J.

Diabetologia. 2004 Feb;47(2):249-58. Epub 2004 Jan 13.PMID: 14722646 [PubMed - indexed for MEDLINE]Related articles

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patané G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P.

Diabetes. 2002 May;51(5):1437-42.PMID: 11978640 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells.

Eitel K, Staiger H, Rieger J, Mischak H, Brandhorst H, Brendel MD, Bretzel RG, Häring HU, Kellerer M.

Diabetes. 2003 Apr;52(4):991-7.PMID: 12663471 [PubMed - indexed for MEDLINE]Related articlesFree article

Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity.

Dixon G, Nolan J, McClenaghan NH, Flatt PR, Newsholme P.

Clin Sci (Lond). 2004 Feb;106(2):191-9.PMID: 14561212 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1 prevents beta cell glucolipotoxicity.

Buteau J, El-Assaad W, Rhodes CJ, Rosenberg L, Joly E, Prentki M.

Diabetologia. 2004 May;47(5):806-15. Epub 2004 Apr 17.PMID: 15095038 [PubMed - indexed for MEDLINE]Related articles

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.

Shimabukuro M, Zhou YT, Levi M, Unger RH.

Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2498-502.PMID: 9482914 [PubMed - indexed for MEDLINE]Related articlesFree article

Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans.

Zhou YP, Grill V.

J Clin Endocrinol Metab. 1995 May;80(5):1584-90.PMID: 7745004 [PubMed - indexed for MEDLINE]Related articles

FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication.

Maedler K, Fontana A, Ris F, Sergeev P, Toso C, Oberholzer J, Lehmann R, Bachmann F, Tasinato A, Spinas GA, Halban PA, Donath MY.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8236-41.PMID: 12060768 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans.

Gravena C, Mathias PC, Ashcroft SJ.

J Endocrinol. 2002 Apr;173(1):73-80.PMID: 11927386 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.

Zhou YP, Grill VE.

J Clin Invest. 1994 Feb;93(2):870-6.PMID: 8113418 [PubMed - indexed for MEDLINE]Related articlesFree article

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death.

El-Assaad W, Buteau J, Peyot ML, Nolan C, Roduit R, Hardy S, Joly E, Dbaibo G, Rosenberg L, Prentki M.

Endocrinology. 2003 Sep;144(9):4154-63.PMID: 12933690 [PubMed - indexed for MEDLINE]Related articlesFree article

Different role of saturated and unsaturated fatty acids in beta-cell apoptosis.

Eitel K, Staiger H, Brendel MD, Brandhorst D, Bretzel RG, Häring HU, Kellerer M.

Biochem Biophys Res Commun. 2002 Dec 20;299(5):853-6.PMID: 12470657 [PubMed - indexed for MEDLINE]Related articles

Effects of ethanol on pancreatic beta-cell death: interaction with glucose and fatty acids.

Dembele K, Nguyen KH, Hernandez TA, Nyomba BL.

Cell Biol Toxicol. 2009 Apr;25(2):141-52. Epub 2008 Mar 11.PMID: 18330713 [PubMed - indexed for MEDLINE]Related articles

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.

Kelpe CL, Moore PC, Parazzoli SD, Wicksteed B, Rhodes CJ, Poitout V.

J Biol Chem. 2003 Aug 8;278(32):30015-21. Epub 2003 May 27.PMID: 12771145 [PubMed - indexed for MEDLINE]Related articlesFree article

Palmitate-induced cardiac apoptosis is mediated through CPT-1 but not influenced by glucose and insulin.

Kong JY, Rabkin SW.

Am J Physiol Heart Circ Physiol. 2002 Feb;282(2):H717-25.PMID: 11788422 [PubMed - indexed for MEDLINE]Related articlesFree article