PubMed

Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice.

Zhang YC, Pileggi A, Agarwal A, Molano RD, Powers M, Brusko T, Wasserfall C, Goudy K, Zahr E, Poggioli R, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Nick H, Flotte T, Ellis TM, Ricordi C, Inverardi L, Atkinson MA.

Diabetes. 2003 Mar;52(3):708-16.PMID: 12606512 [PubMed - indexed for MEDLINE]Related articlesFree article

Adeno-associated virus (AAV) as a vehicle for therapeutic gene delivery: improvements in vector design and viral production enhance potential to prolong graft survival in pancreatic islet cell transplantation for the reversal of type 1 diabetes.

Kapturczak MH, Flotte T, Atkinson MA.

Curr Mol Med. 2001 May;1(2):245-58. Review.PMID: 11899074 [PubMed - indexed for MEDLINE]Related articles

Interleukin-4 or interleukin-10 expressed from adenovirus-transduced syngeneic islet grafts fails to prevent beta cell destruction in diabetic NOD mice.

Smith DK, Korbutt GS, Suarez-Pinzon WL, Kao D, Rajotte RV, Elliott JF.

Transplantation. 1997 Oct 15;64(7):1040-9.PMID: 9381527 [PubMed - indexed for MEDLINE]Related articles

Systemic overexpression of interleukin-10 fails to protect allogeneic islet transplants in nonobese diabetic mice.

Zhang YC, Pileggi A, Molano RD, Wasserfall C, Campbell-Thompson M, Ricordi C, Atkinson MA, Inverardi L.

Transplantation. 2005 Aug 27;80(4):530-3.PMID: 16123729 [PubMed - indexed for MEDLINE]Related articles

Viral IL-10-mediated immune regulation in pancreatic islet transplantation.

Carter JD, Ellett JD, Chen M, Smith KM, Fialkow LB, McDuffie MJ, Tung KS, Nadler JL, Yang Z.

Mol Ther. 2005 Aug;12(2):360-8.PMID: 16043104 [PubMed - indexed for MEDLINE]Related articles

Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.

Goudy KS, Burkhardt BR, Wasserfall C, Song S, Campbell-Thompson ML, Brusko T, Powers MA, Clare-Salzler MJ, Sobel ES, Ellis TM, Flotte TR, Atkinson MA.

J Immunol. 2003 Sep 1;171(5):2270-8.PMID: 12928371 [PubMed - indexed for MEDLINE]Related articlesFree article

Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice.

Goudy K, Song S, Wasserfall C, Zhang YC, Kapturczak M, Muir A, Powers M, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Ellis TM, Flotte TR, Atkinson MA.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13913-8.PMID: 11717448 [PubMed - indexed for MEDLINE]Related articlesFree article

Adeno-associated virus transduction of islets with interleukin-4 results in impaired metabolic function in syngeneic marginal islet mass transplantation.

Zhang YC, Molano RD, Pileggi A, Powers M, Cross J, Wasserfall C, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Flotte T, Ellis TM, Ricordi C, Atkinson MA, Inverardi L.

Transplantation. 2002 Oct 27;74(8):1184-6.PMID: 12438968 [PubMed - indexed for MEDLINE]Related articles

Combined therapy with interleukin-4 and interleukin-10 inhibits autoimmune diabetes recurrence in syngeneic islet-transplanted nonobese diabetic mice. Analysis of cytokine mRNA expression in the graft.

Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC, Power RF, Rajotte RV.

Transplantation. 1995 Aug 27;60(4):368-74.PMID: 7652767 [PubMed - indexed for MEDLINE]Related articles

Testicular sertoli cells protect islet beta-cells from autoimmune destruction in NOD mice by a transforming growth factor-beta1-dependent mechanism.

Suarez-Pinzon W, Korbutt GS, Power R, Hooton J, Rajotte RV, Rabinovitch A.

Diabetes. 2000 Nov;49(11):1810-8.PMID: 11078447 [PubMed - indexed for MEDLINE]Related articlesFree article

BCG immunotherapy prevents recurrence of diabetes in islet grafts transplanted into spontaneously diabetic NOD mice.

Lakey JR, Singh B, Warnock GL, Rajotte RV.

Transplantation. 1994 Apr 27;57(8):1213-7.PMID: 8178349 [PubMed - indexed for MEDLINE]Related articles

Adeno-associated virus vector mediated gene transfer to pancreatic beta cells.

Prasad KM, Yang Z, Bleich D, Nadler JL.

Gene Ther. 2000 Sep;7(18):1553-61.PMID: 11021593 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of autoimmune destruction of syngeneic islet grafts in spontaneously diabetic nonobese diabetic mice by a combination of a vitamin D3 analog and cyclosporine.

Casteels K, Waer M, Laureys J, Valckx D, Depovere J, Bouillon R, Mathieu C.

Transplantation. 1998 May 15;65(9):1225-32.PMID: 9603172 [PubMed - indexed for MEDLINE]Related articles

Impact of donor immune cells in pancreatic islet transplantation.

Carter JD, Chen M, Ellett JD, Smith KM, Nadler JL, Yang Z.

Transplant Proc. 2004 Nov;36(9):2866-8.PMID: 15621170 [PubMed - indexed for MEDLINE]Related articles

Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectors.

Flotte T, Agarwal A, Wang J, Song S, Fenjves ES, Inverardi L, Chesnut K, Afione S, Loiler S, Wasserfall C, Kapturczak M, Ellis T, Nick H, Atkinson M.

Diabetes. 2001 Mar;50(3):515-20.PMID: 11246870 [PubMed - indexed for MEDLINE]Related articlesFree article

Local expression of immunoregulatory IL-12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice.

Yasuda H, Nagata M, Arisawa K, Yoshida R, Fujihira K, Okamoto N, Moriyama H, Miki M, Saito I, Hamada H, Yokono K, Kasuga M.

J Clin Invest. 1998 Nov 15;102(10):1807-14.PMID: 9819366 [PubMed - indexed for MEDLINE]Related articlesFree article

Combination therapy with cyclosporine and interleukin-4 or interleukin-10 prolongs survival of synergeneic pancreatic islet grafts in nonobese diabetic mice: islet graft survival does not correlate with mRNA levels of type 1 or type 2 cytokines, or transforming growth factor-beta in the islet grafts.

Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Rajotte RV, Power RF.

Transplantation. 1997 Dec 15;64(11):1525-31.PMID: 9415551 [PubMed - indexed for MEDLINE]Related articles

Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice.

Luo X, Yang H, Kim IS, Saint-Hilaire F, Thomas DA, De BP, Ozkaynak E, Muthukumar T, Hancock WW, Crystal RG, Suthanthiran M.

Transplantation. 2005 May 15;79(9):1091-6.PMID: 15880049 [PubMed - indexed for MEDLINE]Related articles

Nondepleting anti-CD4 and soluble interleukin-1 receptor prevent autoimmune destruction of syngeneic islet grafts in diabetic NOD mice.

Drage M, Zaccone P, Phillips JM, Nicoletti F, Dawson J, Andrew Bradley J, Cooke A.

Transplantation. 2002 Sep 15;74(5):611-9.PMID: 12352875 [PubMed - indexed for MEDLINE]Related articles

Primary nonfunction of islet grafts in autoimmune diabetic nonobese diabetic mice is prevented by treatment with interleukin-4 and interleukin-10.

Faust A, Rothe H, Schade U, Lampeter E, Kolb H.

Transplantation. 1996 Sep 15;62(5):648-52.PMID: 8830831 [PubMed - indexed for MEDLINE]Related articles