PubMed

Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection.

Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H.

Diabetes. 2003 Mar;52(3):581-7. Review.PMID: 12606496 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of oxidative stress in pancreatic beta-cell dysfunction.

Kajimoto Y, Kaneto H.

Ann N Y Acad Sci. 2004 Apr;1011:168-76.PMID: 15126294 [PubMed - indexed for MEDLINE]Related articles

Chronic oxidative stress as a mechanism for glucose toxicity of the beta cell in type 2 diabetes.

Robertson R, Zhou H, Zhang T, Harmon JS.

Cell Biochem Biophys. 2007;48(2-3):139-46.PMID: 17709883 [PubMed - indexed for MEDLINE]Related articles

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants.

Tanaka Y, Gleason CE, Tran PO, Harmon JS, Robertson RP.

Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10857-62.PMID: 10485916 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet beta cell.

Robertson RP, Harmon JS.

Free Radic Biol Med. 2006 Jul 15;41(2):177-84. Epub 2006 May 4. Review.PMID: 16814095 [PubMed - indexed for MEDLINE]Related articles

A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity.

Tanaka Y, Tran PO, Harmon J, Robertson RP.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12363-8. Epub 2002 Sep 6.PMID: 12218186 [PubMed - indexed for MEDLINE]Related articlesFree article

Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.

Kaneto H, Kajimoto Y, Miyagawa J, Matsuoka T, Fujitani Y, Umayahara Y, Hanafusa T, Matsuzawa Y, Yamasaki Y, Hori M.

Diabetes. 1999 Dec;48(12):2398-406.PMID: 10580429 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells.

Harmon JS, Stein R, Robertson RP.

J Biol Chem. 2005 Mar 25;280(12):11107-13. Epub 2005 Jan 20.PMID: 15664999 [PubMed - indexed for MEDLINE]Related articlesFree article

IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes.

Leibowitz G, Ferber S, Apelqvist A, Edlund H, Gross DJ, Cerasi E, Melloul D, Kaiser N.

Diabetes. 2001 Aug;50(8):1799-806.PMID: 11473041 [PubMed - indexed for MEDLINE]Related articlesFree article

Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15.

Moran A, Zhang HJ, Olson LK, Harmon JS, Poitout V, Robertson RP.

J Clin Invest. 1997 Feb 1;99(3):534-9.PMID: 9022089 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression.

Harmon JS, Gleason CE, Tanaka Y, Oseid EA, Hunter-Berger KK, Robertson RP.

Diabetes. 1999 Oct;48(10):1995-2000.PMID: 10512364 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of glycation suppresses glucokinase gene expression in HIT-T15 cells.

Kajimoto Y, Matsuoka T, Kaneto H, Watada H, Fujitani Y, Kishimoto M, Sakamoto K, Matsuhisa M, Kawamori R, Yamasaki Y, Hori M.

Diabetologia. 1999 Dec;42(12):1417-24.PMID: 10651260 [PubMed - indexed for MEDLINE]Related articles

Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes.

Robertson RP, Harmon J, Tran PO, Poitout V.

Diabetes. 2004 Feb;53 Suppl 1:S119-24. Review.PMID: 14749276 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells.

Matsuoka T, Kajimoto Y, Watada H, Kaneto H, Kishimoto M, Umayahara Y, Fujitani Y, Kamada T, Kawamori R, Yamasaki Y.

J Clin Invest. 1997 Jan 1;99(1):144-50.PMID: 9011569 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.

Hagman DK, Latour MG, Chakrabarti SK, Fontes G, Amyot J, Tremblay C, Semache M, Lausier JA, Roskens V, Mirmira RG, Jetton TL, Poitout V.

Diabetes. 2008 Feb;57(2):424-31. Epub 2007 Nov 8.PMID: 17991758 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic Duodenal Homeobox (PDX-1) in health and disease.

Melloul D, Tsur A, Zangen D.

J Pediatr Endocrinol Metab. 2002 Nov-Dec;15(9):1461-72. Review.PMID: 12503852 [PubMed - indexed for MEDLINE]Related articles

Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus.

Seufert J, Weir GC, Habener JF.

J Clin Invest. 1998 Jun 1;101(11):2528-39.PMID: 9616224 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

Donath MY, Gross DJ, Cerasi E, Kaiser N.

Diabetes. 1999 Apr;48(4):738-44.PMID: 10102689 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes.

Leibowitz G, Yuli M, Donath MY, Nesher R, Melloul D, Cerasi E, Gross DJ, Kaiser N.

Diabetes. 2001 Feb;50 Suppl 1:S113-7.PMID: 11272167 [PubMed - indexed for MEDLINE]Related articles

Prevention of oxidative stress by adenoviral overexpression of glutathione-related enzymes in pancreatic islets.

Robertson RP, Tanaka Y, Takahashi H, Tran PO, Harmon JS.

Ann N Y Acad Sci. 2005 Jun;1043:513-20.PMID: 16037273 [PubMed - indexed for MEDLINE]Related articles