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    Results: 1 to 20 of 158

    1.

    The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.

    Nielsen EM, Hansen L, Carstensen B, Echwald SM, Drivsholm T, Glümer C, Thorsteinsson B, Borch-Johnsen K, Hansen T, Pedersen O.

    Diabetes. 2003 Feb;52(2):573-7.PMID: 12540638 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    The E23K variant in the Kir6.2 subunit of the ATP-sensitive K+ channel does not augment impaired glucose tolerance in Caribbean subjects with a family history of type 2 diabetes.

    Ezenwaka C, Kalloo R, Uhlig M, Schwenk R, Eckel J.

    J Endocrinol. 2005 Jun;185(3):439-44.PMID: 15930170 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.

    Villareal DT, Koster JC, Robertson H, Akrouh A, Miyake K, Bell GI, Patterson BW, Nichols CG, Polonsky KS.

    Diabetes. 2009 Aug;58(8):1869-78. Epub 2009 Jun 2.PMID: 19491206 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Impact of Kir6.2 E23K polymorphism on the development of type 2 diabetes in a general Japanese population: The Hisayama Study.

    Doi Y, Kubo M, Ninomiya T, Yonemoto K, Iwase M, Arima H, Hata J, Tanizaki Y, Iida M, Kiyohara Y.

    Diabetes. 2007 Nov;56(11):2829-33.PMID: 17965318 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.

    Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM.

    Diabetes. 2003 Feb;52(2):568-72.PMID: 12540637 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.

    Sesti G, Laratta E, Cardellini M, Andreozzi F, Del Guerra S, Irace C, Gnasso A, Grupillo M, Lauro R, Hribal ML, Perticone F, Marchetti P.

    J Clin Endocrinol Metab. 2006 Jun;91(6):2334-9. Epub 2006 Apr 4.PMID: 16595597 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.

    Florez JC, Burtt N, de Bakker PI, Almgren P, Tuomi T, Holmkvist J, Gaudet D, Hudson TJ, Schaffner SF, Daly MJ, Hirschhorn JN, Groop L, Altshuler D.

    Diabetes. 2004 May;53(5):1360-8.PMID: 15111507 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses.

    van Dam RM, Hoebee B, Seidell JC, Schaap MM, de Bruin TW, Feskens EJ.

    Diabet Med. 2005 May;22(5):590-8.PMID: 15842514 [PubMed - indexed for MEDLINE]Related articles

    9.

    Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.

    Florez JC, Jablonski KA, Kahn SE, Franks PW, Dabelea D, Hamman RF, Knowler WC, Nathan DM, Altshuler D.

    Diabetes. 2007 Feb;56(2):531-6.PMID: 17259403 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians.

    Hani EH, Boutin P, Durand E, Inoue H, Permutt MA, Velho G, Froguel P.

    Diabetologia. 1998 Dec;41(12):1511-5.PMID: 9867219 [PubMed - indexed for MEDLINE]Related articles

    11.

    Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus.

    Shaat N, Ekelund M, Lernmark A, Ivarsson S, Almgren P, Berntorp K, Groop L.

    Diabetologia. 2005 Dec;48(12):2544-51. Epub 2005 Nov 17.PMID: 16320083 [PubMed - indexed for MEDLINE]Related articles

    12.

    Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes.

    Müssig K, Staiger H, Machicao F, Stancáková A, Kuusisto J, Laakso M, Thamer C, Machann J, Schick F, Claussen CD, Stefan N, Fritsche A, Häring HU.

    J Clin Endocrinol Metab. 2009 Apr;94(4):1353-60. Epub 2009 Jan 13.PMID: 19141580 [PubMed - indexed for MEDLINE]Related articles

    13.

    Genetic variations in the pancreatic ATP-sensitive potassium channel, beta-cell dysfunction, and susceptibility to type 2 diabetes.

    Chistiakov DA, Potapov VA, Khodirev DC, Shamkhalova MS, Shestakova MV, Nosikov VV.

    Acta Diabetol. 2009 Mar;46(1):43-9. Epub 2008 Aug 29.PMID: 18758683 [PubMed - indexed for MEDLINE]Related articles

    14.

    Association between KCNJ11 E23K genotype and cardiovascular and glucose metabolism phenotypes in older men and women.

    Yi Y, Dongmei L, Phares DA, Weiss EP, Brandauer J, Hagberg JM.

    Exp Physiol. 2008 Jan;93(1):95-103. Epub 2007 Aug 24.PMID: 17720745 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell.

    't Hart LM, van Haeften TW, Dekker JM, Bot M, Heine RJ, Maassen JA.

    Diabetes. 2002 Oct;51(10):3135-8.PMID: 12351459 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Genetic variability of the SUR1 promoter in relation to beta-cell function and Type II diabetes mellitus.

    Hansen T, Ambye L, Grarup N, Hansen L, Echwald SM, Ferrer J, Pedersen O.

    Diabetologia. 2001 Oct;44(10):1330-4.PMID: 11692183 [PubMed - indexed for MEDLINE]Related articles

    17.

    Relationship between E23K (an established type II diabetes-susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels.

    Barber TM, Bennett AJ, Gloyn AL, Groves CJ, Sovio U, Ruokonen A, Martikainen H, Pouta A, Taponen S, Weedon MN, Hartikainen AL, Wass JA, Järvelin MR, Zeggini E, Franks S, McCarthy MI.

    Eur J Hum Genet. 2007 Jun;15(6):679-84. Epub 2007 Mar 7.PMID: 17342155 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion.

    Johansen A, Nielsen EM, Andersen G, Hamid YH, Jensen DP, Glümer C, Drivsholm T, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O.

    Diabetologia. 2004 Aug;47(8):1437-41. Epub 2004 Jul 17.PMID: 15258737 [PubMed - indexed for MEDLINE]Related articles

    19.

    Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53).

    Gloyn AL, Hashim Y, Ashcroft SJ, Ashfield R, Wiltshire S, Turner RC; UK Prospective Diabetes Study (UKPDS 53).

    Diabet Med. 2001 Mar;18(3):206-12. Erratum in: Diabet Med. 2003 Mar;20(3):252.. PMID: 11318841 [PubMed - indexed for MEDLINE]Related articles

    20.

    Studies of relationships between the GLUT10 Ala206Thr polymorphism and impaired insulin secretion.

    Rose CS, Andersen G, Hamid YH, Glümer C, Drivsholm T, Borch-Johnsen K, Jørgensen T, Pedersen O, Hansen T.

    Diabet Med. 2005 Jul;22(7):946-9.PMID: 15975113 [PubMed - indexed for MEDLINE]Related articles

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