PubMed

A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat.

Asnaghi V, Gerhardinger C, Hoehn T, Adeboje A, Lorenzi M.

Diabetes. 2003 Feb;52(2):506-11.PMID: 12540628 [PubMed - indexed for MEDLINE]Related articlesFree article

A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy.

Sun W, Oates PJ, Coutcher JB, Gerhardinger C, Lorenzi M.

Diabetes. 2006 Oct;55(10):2757-62.PMID: 17003340 [PubMed - indexed for MEDLINE]Related articlesFree article

Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis.

Drel VR, Pacher P, Ali TK, Shin J, Julius U, El-Remessy AB, Obrosova IG.

Int J Mol Med. 2008 Jun;21(6):667-76.PMID: 18506358 [PubMed - indexed for MEDLINE]Related articlesFree article

Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy.

Dagher Z, Park YS, Asnaghi V, Hoehn T, Gerhardinger C, Lorenzi M.

Diabetes. 2004 Sep;53(9):2404-11.PMID: 15331552 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group.

Barber AJ, Antonetti DA, Gardner TW.

Invest Ophthalmol Vis Sci. 2000 Oct;41(11):3561-8.PMID: 11006253 [PubMed - indexed for MEDLINE]Related articlesFree article

Glial reactivity, an early feature of diabetic retinopathy.

Rungger-Brändle E, Dosso AA, Leuenberger PM.

Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1971-80.PMID: 10845624 [PubMed - indexed for MEDLINE]Related articlesFree article

Early retinal damage in experimental diabetes: electroretinographical and morphological observations.

Li Q, Zemel E, Miller B, Perlman I.

Exp Eye Res. 2002 May;74(5):615-25.PMID: 12076083 [PubMed - indexed for MEDLINE]Related articles

An aldose reductase inhibitor and aminoguanidine prevent vascular endothelial growth factor expression in rats with long-term galactosemia.

Frank RN, Amin R, Kennedy A, Hohman TC.

Arch Ophthalmol. 1997 Aug;115(8):1036-47.PMID: 9258227 [PubMed - indexed for MEDLINE]Related articles

Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy.

Obrosova IG, Stevens MJ, Lang HJ.

Pharmacology. 2001;62(3):172-80.PMID: 11287819 [PubMed - indexed for MEDLINE]Related articles

Retinal glial cell immunoreactivity and neuronal cell changes in rats with STZ-induced diabetes.

Agardh E, Bruun A, Agardh CD.

Curr Eye Res. 2001 Oct;23(4):276-84.PMID: 11852429 [PubMed - indexed for MEDLINE]Related articles

Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes.

Feit-Leichman RA, Kinouchi R, Takeda M, Fan Z, Mohr S, Kern TS, Chen DF.

Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4281-7.PMID: 16249509 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular filtration function in galactose-fed versus diabetic rats: the role of polyol pathway activity.

Pugliese G, Tilton RG, Speedy A, Chang K, Province MA, Kilo C, Williamson JR.

Metabolism. 1990 Jul;39(7):690-7.PMID: 2114513 [PubMed - indexed for MEDLINE]Related articles

Effects of an aldose reductase inhibitor, SNK-860, on the histopathological changes of retinal tissues in a streptozotocin-induced diabetic rat model.

Akita M, Mizuno K, Matsubara A, Nakano K, Kurono M.

Acta Med Okayama. 1993 Oct;47(5):299-304.PMID: 8273453 [PubMed - indexed for MEDLINE]Related articles

Fructose-3-phosphate production and polyol pathway metabolism in diabetic rat hearts.

Lal S, Randall WC, Taylor AH, Kappler F, Walker M, Brown TR, Szwergold BS.

Metabolism. 1997 Nov;46(11):1333-8.PMID: 9361695 [PubMed - indexed for MEDLINE]Related articles

Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group.

Lieth E, Barber AJ, Xu B, Dice C, Ratz MJ, Tanase D, Strother JM.

Diabetes. 1998 May;47(5):815-20. Erratum in: Diabetes 1998 Jul;47(7):1170. PMID: 9588455 [PubMed - indexed for MEDLINE]Related articlesFree article

Continuous inhibition of excessive polyol pathway flux in peripheral nerves by aldose reductase inhibitor fidarestat leads to improvement of diabetic neuropathy.

Mizuno K, Kato N, Makino M, Suzuki T, Shindo M.

J Diabetes Complications. 1999 May-Jun;13(3):141-50.PMID: 10509874 [PubMed - indexed for MEDLINE]Related articles

Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats.

Obrosova IG, Minchenko AG, Vasupuram R, White L, Abatan OI, Kumagai AK, Frank RN, Stevens MJ.

Diabetes. 2003 Mar;52(3):864-71.PMID: 12606532 [PubMed - indexed for MEDLINE]Related articlesFree article

Lowered cortistatin expression is an early event in the human diabetic retina and is associated with apoptosis and glial activation.

Carrasco E, Hernández C, de Torres I, Farrés J, Simó R.

Mol Vis. 2008 Aug 15;14:1496-502.PMID: 18709137 [PubMed - indexed for MEDLINE]Related articlesFree article

Sorbitol dehydrogenase overexpression potentiates glucose toxicity to cultured retinal pericytes.

Amano S, Yamagishi S, Kato N, Inagaki Y, Okamoto T, Makino M, Taniko K, Hirooka H, Jomori T, Takeuchi M.

Biochem Biophys Res Commun. 2002 Nov 29;299(2):183-8.PMID: 12437967 [PubMed - indexed for MEDLINE]Related articles

Early changes in glial reactivity and lipid peroxidation in diabetic rat retina: effects of melatonin.

Baydas G, Tuzcu M, Yasar A, Baydas B.

Acta Diabetol. 2004 Sep;41(3):123-8.PMID: 15666580 [PubMed - indexed for MEDLINE]Related articles