PubMed

Pax-6 activates endogenous proglucagon gene expression in the rodent gastrointestinal epithelium.

Trinh DK, Zhang K, Hossain M, Brubaker PL, Drucker DJ.

Diabetes. 2003 Feb;52(2):425-33.PMID: 12540617 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription.

Hill ME, Asa SL, Drucker DJ.

Mol Endocrinol. 1999 Sep;13(9):1474-86.PMID: 10478839 [PubMed - indexed for MEDLINE]Related articlesFree article

Pax-2 activates the proglucagon gene promoter but is not essential for proglucagon gene expression or development of proglucagon-producing cell lineages in the murine pancreas or intestine.

Flock G, Drucker DJ.

Mol Endocrinol. 2002 Oct;16(10):2349-59.PMID: 12351699 [PubMed - indexed for MEDLINE]Related articlesFree article

The caudal homeobox protein cdx-2/3 activates endogenous proglucagon gene expression in InR1-G9 islet cells.

Jin T, Trinh DK, Wang F, Drucker DJ.

Mol Endocrinol. 1997 Feb;11(2):203-9.PMID: 9013767 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator.

Hussain MA, Habener JF.

J Biol Chem. 1999 Oct 8;274(41):28950-7.PMID: 10506141 [PubMed - indexed for MEDLINE]Related articlesFree article

Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression.

Liu Y, Shen W, Brubaker PL, Kaestner KH, Drucker DJ.

Biochem J. 2002 Sep 1;366(Pt 2):633-41.PMID: 12000309 [PubMed - indexed for MEDLINE]Related articlesFree article

Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression.

Gosmain Y, Avril I, Mamin A, Philippe J.

J Biol Chem. 2007 Nov 30;282(48):35024-34. Epub 2007 Sep 27.PMID: 17901057 [PubMed - indexed for MEDLINE]Related articlesFree article

Aberrant regulation of human intestinal proglucagon gene expression in the NCI-H716 cell line.

Cao X, Flock G, Choi C, Irwin DM, Drucker DJ.

Endocrinology. 2003 May;144(5):2025-33.PMID: 12697711 [PubMed - indexed for MEDLINE]Related articlesFree article

The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6.

Ritz-Laser B, Estreicher A, Gauthier BR, Mamin A, Edlund H, Philippe J.

Diabetologia. 2002 Jan;45(1):97-107.PMID: 11845228 [PubMed - indexed for MEDLINE]Related articles

Divergent regulation of human and rat proglucagon gene promoters in vivo.

Nian M, Drucker DJ, Irwin D.

Am J Physiol. 1999 Oct;277(4 Pt 1):G829-37.PMID: 10516149 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3.

Jin T, Drucker DJ.

Mol Cell Biol. 1996 Jan;16(1):19-28.PMID: 8524295 [PubMed - indexed for MEDLINE]Related articlesFree article

Pax-6 and Cdx-2/3 interact to activate glucagon gene expression on the G1 control element.

Ritz-Laser B, Estreicher A, Klages N, Saule S, Philippe J.

J Biol Chem. 1999 Feb 12;274(7):4124-32.PMID: 9933606 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of Cdx-2 in insulin and proglucagon gene expression: a study using the RIN-1056A cell line with an inducible gene expression system.

Zhao Y, Liu T, Zhang N, Yi F, Wang Q, Fantus IG, Jin T.

J Endocrinol. 2005 Jul;186(1):179-92.PMID: 16002547 [PubMed - indexed for MEDLINE]Related articlesFree article

Pdx-1 is not sufficient for repression of proglucagon gene transcription in islet or enteroendocrine cells.

Flock G, Cao X, Drucker DJ.

Endocrinology. 2005 Jan;146(1):441-9. Epub 2004 Oct 7.PMID: 15471960 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line.

Drucker DJ, Jin T, Asa SL, Young TA, Brubaker PL.

Mol Endocrinol. 1994 Dec;8(12):1646-55.PMID: 7535893 [PubMed - indexed for MEDLINE]Related articles

POU domain transcription factor brain 4 confers pancreatic alpha-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element.

Hussain MA, Lee J, Miller CP, Habener JF.

Mol Cell Biol. 1997 Dec;17(12):7186-94.PMID: 9372951 [PubMed - indexed for MEDLINE]Related articlesFree article

Coregulation of glucagon-like peptide-1 synthesis with proglucagon and prohormone convertase 1 gene expression in enteroendocrine GLUTag cells.

Dhanvantari S, Izzo A, Jansen E, Brubaker PL.

Endocrinology. 2001 Jan;142(1):37-42.PMID: 11145564 [PubMed - indexed for MEDLINE]Related articlesFree article

The paired homeodomain transcription factor Pax-2 is expressed in the endocrine pancreas and transactivates the glucagon gene promoter.

Ritz-Laser B, Estreicher A, Gauthier B, Philippe J.

J Biol Chem. 2000 Oct 20;275(42):32708-15.PMID: 10938089 [PubMed - indexed for MEDLINE]Related articlesFree article

PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AMP.

Chen L, Wang P, Andrade CF, Zhao IY, Dubé PE, Brubaker PL, Liu M, Jin T.

FEBS J. 2005 Jun;272(11):2746-59.PMID: 15943809 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells.

Ni Z, Anini Y, Fang X, Mills G, Brubaker PL, Jin T.

J Biol Chem. 2003 Jan 10;278(2):1380-7. Epub 2002 Nov 5.PMID: 12421827 [PubMed - indexed for MEDLINE]Related articlesFree article