PubMed

Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid.

Hull RL, Andrikopoulos S, Verchere CB, Vidal J, Wang F, Cnop M, Prigeon RL, Kahn SE.

Diabetes. 2003 Feb;52(2):372-9.PMID: 12540610 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

Andrikopoulos S, Verchere CB, Terauchi Y, Kadowaki T, Kahn SE.

Diabetes. 2000 Dec;49(12):2056-62.PMID: 11118007 [PubMed - indexed for MEDLINE]Related articlesFree article

Human islet amyloid polypeptide transgenic mice: in vivo and ex vivo models for the role of hIAPP in type 2 diabetes mellitus.

Höppener JW, Jacobs HM, Wierup N, Sotthewes G, Sprong M, de Vos P, Berger R, Sundler F, Ahrén B.

Exp Diabetes Res. 2008;2008:697035.PMID: 18497871 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.

D'Alessio DA, Verchere CB, Kahn SE, Hoagland V, Baskin DG, Palmiter RD, Ensinck JW.

Diabetes. 1994 Dec;43(12):1457-61.PMID: 7958499 [PubMed - indexed for MEDLINE]Related articles

Identification of the amyloid-degrading enzyme neprilysin in mouse islets and potential role in islet amyloidogenesis.

Zraika S, Hull RL, Udayasankar J, Clark A, Utzschneider KM, Tong J, Gerchman F, Kahn SE.

Diabetes. 2007 Feb;56(2):304-10. Erratum in: Diabetes. 2007 Jun;56(6):1746. PMID: 17259373 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro.

Hull RL, Zraika S, Udayasankar J, Kisilevsky R, Szarek WA, Wight TN, Kahn SE.

Am J Physiol Cell Physiol. 2007 Nov;293(5):C1586-93. Epub 2007 Sep 5.PMID: 17804609 [PubMed - indexed for MEDLINE]Related articlesFree article

Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model.

Höppener JW, Oosterwijk C, Nieuwenhuis MG, Posthuma G, Thijssen JH, Vroom TM, Ahrén B, Lips CJ.

Diabetologia. 1999 Apr;42(4):427-34.PMID: 10230646 [PubMed - indexed for MEDLINE]Related articles

Glucose- and time-dependence of islet amyloid formation in vitro.

Zraika S, Hull RL, Udayasankar J, Utzschneider KM, Tong J, Gerchman F, Kahn SE.

Biochem Biophys Res Commun. 2007 Mar 2;354(1):234-9. Epub 2007 Jan 2.PMID: 17222388 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide.

Hull RL, Shen ZP, Watts MR, Kodama K, Carr DB, Utzschneider KM, Zraika S, Wang F, Kahn SE.

Diabetes. 2005 Jul;54(7):2235-44.PMID: 15983227 [PubMed - indexed for MEDLINE]Related articlesFree article

Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.

de Koning EJ, Morris ER, Hofhuis FM, Posthuma G, Höppener JW, Morris JF, Capel PJ, Clark A, Verbeek JS.

Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8467-71.PMID: 8078905 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation.

Hull RL, Kodama K, Utzschneider KM, Carr DB, Prigeon RL, Kahn SE.

Diabetologia. 2005 Jul;48(7):1350-8. Epub 2005 Jun 4.PMID: 15937671 [PubMed - indexed for MEDLINE]Related articles

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid.

Butler AE, Janson J, Soeller WC, Butler PC.

Diabetes. 2003 Sep;52(9):2304-14.PMID: 12941770 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice.

Vidal J, Verchere CB, Andrikopoulos S, Wang F, Hull RL, Cnop M, Olin KL, LeBoeuf RC, O'Brien KD, Chait A, Kahn SE.

Diabetologia. 2003 Jan;46(1):71-9. Epub 2003 Jan 9.PMID: 12637985 [PubMed - indexed for MEDLINE]Related articles

Postnatally disturbed pancreatic islet cell distribution in human islet amyloid polypeptide transgenic mice.

Wong HY, Ahrén B, Lips CJ, Höppener JW, Sundler F.

Regul Pept. 2003 May 15;113(1-3):89-94.PMID: 12686466 [PubMed - indexed for MEDLINE]Related articles

Spontaneous diabetes in hemizygous human amylin transgenic mice that developed neither islet amyloid nor peripheral insulin resistance.

Wong WP, Scott DW, Chuang CL, Zhang S, Liu H, Ferreira A, Saafi EL, Choong YS, Cooper GJ.

Diabetes. 2008 Oct;57(10):2737-44. Epub 2008 Jul 15.PMID: 18633116 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?

Clark A, Nilsson MR.

Diabetologia. 2004 Feb;47(2):157-69. Epub 2004 Jan 13. Review.PMID: 14722650 [PubMed - indexed for MEDLINE]Related articles

Oophorectomy promotes islet amyloid formation in a transgenic mouse model of Type II diabetes.

Kahn SE, Andrikopoulos S, Verchere CB, Wang F, Hull RL, Vidal J.

Diabetologia. 2000 Oct;43(10):1309-12.PMID: 11079750 [PubMed - indexed for MEDLINE]Related articles

Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress.

Matveyenko AV, Gurlo T, Daval M, Butler AE, Butler PC.

Diabetes. 2009 Apr;58(4):906-16. Epub 2009 Jan 16.PMID: 19151199 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice.

Hull RL, Watts MR, Kodama K, Shen ZP, Utzschneider KM, Carr DB, Vidal J, Kahn SE.

Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E703-9. Epub 2005 May 17. Erratum in: Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E205. PMID: 15899941 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide.

Huang CJ, Haataja L, Gurlo T, Butler AE, Wu X, Soeller WC, Butler PC.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1656-62. Epub 2007 Oct 2.PMID: 17911343 [PubMed - indexed for MEDLINE]Related articlesFree article