PubMed

Accelerated diabetes in rat insulin promoter-tumor necrosis factor-alpha transgenic nonobese diabetic mice lacking major histocompatibility class II molecules.

Rajagopalan G, Kudva YC, Flavell RA, David CS.

Diabetes. 2003 Feb;52(2):342-7.PMID: 12540606 [PubMed - indexed for MEDLINE]Related articlesFree article

Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells.

Grewal IS, Grewal KD, Wong FS, Picarella DE, Janeway CA Jr, Flavell RA.

J Exp Med. 1996 Nov 1;184(5):1963-74.PMID: 8920883 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of insulitis and type 1 diabetes by transgenic HLA-DR3 and DQ8 in NOD mice lacking endogenous MHC class II.

Kudva YC, Rajagopalan G, Raju R, Abraham RS, Smart M, Hanson J, David CS.

Hum Immunol. 2002 Nov;63(11):987-99.PMID: 12392851 [PubMed - indexed for MEDLINE]Related articles

Distinct local immunogenic stimuli dictate differential requirements for CD4+ and CD8+ T cell subsets in the pathogenesis of spontaneous autoimmune diabetes.

Rajagopalan G, Mangalam AK, Sen MM, Kudva YC, David CS.

Autoimmunity. 2007 Nov;40(7):489-96.PMID: 17966038 [PubMed - indexed for MEDLINE]Related articles

Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice.

Picarella DE, Kratz A, Li CB, Ruddle NH, Flavell RA.

J Immunol. 1993 May 1;150(9):4136-50.PMID: 7682590 [PubMed - indexed for MEDLINE]Related articles

Autoimmune diabetes in HLA-DR3/DQ8 transgenic mice expressing the co-stimulatory molecule B7-1 in the beta cells of islets of Langerhans.

Rajagopalan G, Kudva YC, Chen L, Wen L, David CS.

Int Immunol. 2003 Sep;15(9):1035-44.PMID: 12917255 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of lymphocyte subsets in accelerated diabetes in nonobese diabetic-rat insulin promoter-B7-1 (NOD-RIP-B7-1) mice.

Wong FS, Visintin I, Wen L, Granata J, Flavell R, Janeway CA.

J Exp Med. 1998 Jun 15;187(12):1985-93.PMID: 9625758 [PubMed - indexed for MEDLINE]Related articlesFree article

H-2D end confers dominant protection from IL-10-mediated acceleration of autoimmune diabetes in the nonobese diabetic mouse.

La Cava A, Balasa B, Good A, van Gunst K, Jung N, Sarvetnick N.

J Immunol. 2001 Jul 15;167(2):1066-71.PMID: 11441117 [PubMed - indexed for MEDLINE]Related articlesFree article

The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model.

Wen L, Chen NY, Tang J, Sherwin R, Wong FS.

J Clin Invest. 2001 Apr;107(7):871-80.PMID: 11285306 [PubMed - indexed for MEDLINE]Related articlesFree article

RIP-beta 2-microglobulin transgene expression restores insulitis, but not diabetes, in beta 2-microglobulin null nonobese diabetic mice.

Kay TW, Parker JL, Stephens LA, Thomas HE, Allison J.

J Immunol. 1996 Oct 15;157(8):3688-93.PMID: 8871671 [PubMed - indexed for MEDLINE]Related articles

Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction.

Chong MM, Chen Y, Darwiche R, Dudek NL, Irawaty W, Santamaria P, Allison J, Kay TW, Thomas HE.

J Immunol. 2004 May 1;172(9):5714-21.PMID: 15100317 [PubMed - indexed for MEDLINE]Related articlesFree article

Two genetic loci regulate T cell-dependent islet inflammation and drive autoimmune diabetes pathogenesis.

Fox CJ, Paterson AD, Mortin-Toth SM, Danska JS.

Am J Hum Genet. 2000 Jul;67(1):67-81. Epub 2000 Jun 9.PMID: 10848492 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules.

Balasa B, Van Gunst K, Jung N, Balakrishna D, Santamaria P, Hanafusa T, Itoh N, Sarvetnick N.

J Immunol. 2000 Sep 1;165(5):2841-9.PMID: 10946317 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of the expression of DR alpha E beta NOD molecule on the development of insulitis and diabetes in the non-obese diabetic (NOD) mouse.

Yamane K, Yamamoto K, Yoshikawa Y, Sasazuki T.

Clin Exp Immunol. 1996 Jan;103(1):141-8.PMID: 8565273 [PubMed - indexed for MEDLINE]Related articlesFree article

IFN beta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice.

Alba A, Puertas MC, Carrillo J, Planas R, Ampudia R, Pastor X, Bosch F, Pujol-Borrell R, Verdaguer J, Vives-Pi M.

J Immunol. 2004 Dec 1;173(11):6667-75.PMID: 15557158 [PubMed - indexed for MEDLINE]Related articlesFree article

Human DQ8 can substitute for murine I-Ag7 in the selection of diabetogenic T cells restricted to I-Ag7.

Wen L, Wong FS, Sherwin R, Mora C.

J Immunol. 2002 Apr 1;168(7):3635-40.PMID: 11907129 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell response.

Ridgway WM, Ito H, Fassò M, Yu C, Fathman CG.

J Exp Med. 1998 Dec 21;188(12):2267-75.PMID: 9858513 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha.

Ohashi PS, Oehen S, Aichele P, Pircher H, Odermatt B, Herrera P, Higuchi Y, Buerki K, Hengartner H, Zinkernagel RM.

J Immunol. 1993 Jun 1;150(11):5185-94.PMID: 8496610 [PubMed - indexed for MEDLINE]Related articles

In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes.

Wen L, Wong FS, Tang J, Chen NY, Altieri M, David C, Flavell R, Sherwin R.

J Exp Med. 2000 Jan 3;191(1):97-104.PMID: 10620608 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-12 administration reveals diabetogenic T cells in genetically resistant I-Ealpha-transgenic nonobese diabetic mice: resistance to autoimmune diabetes is associated with binding of Ealpha-derived peptides to the I-A(g7) molecule.

Trembleau S, Gregori S, Penna G, Gorny I, Adorini L.

J Immunol. 2001 Oct 1;167(7):4104-14.PMID: 11564833 [PubMed - indexed for MEDLINE]Related articlesFree article