PubMed

Regulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinase.

Halse R, Fryer LG, McCormack JG, Carling D, Yeaman SJ.

Diabetes. 2003 Jan;52(1):9-15.PMID: 12502487 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of acute activation of 5'-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle.

Miyamoto L, Toyoda T, Hayashi T, Yonemitsu S, Nakano M, Tanaka S, Ebihara K, Masuzaki H, Hosoda K, Ogawa Y, Inoue G, Fushiki T, Nakao K.

J Appl Physiol. 2007 Mar;102(3):1007-13. Epub 2006 Nov 22.PMID: 17122373 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle.

Wojtaszewski JF, Jørgensen SB, Hellsten Y, Hardie DG, Richter EA.

Diabetes. 2002 Feb;51(2):284-92.PMID: 11812734 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of AICAR treatment on glycogen metabolism in skeletal muscle.

Aschenbach WG, Hirshman MF, Fujii N, Sakamoto K, Howlett KF, Goodyear LJ.

Diabetes. 2002 Mar;51(3):567-73.PMID: 11872652 [PubMed - indexed for MEDLINE]Related articlesFree article

Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

Jørgensen SB, Viollet B, Andreelli F, Frøsig C, Birk JB, Schjerling P, Vaulont S, Richter EA, Wojtaszewski JF.

J Biol Chem. 2004 Jan 9;279(2):1070-9. Epub 2003 Oct 21.PMID: 14573616 [PubMed - indexed for MEDLINE]Related articlesFree article

AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade.

Wang HM, Mehta S, Bansode R, Huang W, Mehta KD.

Biochem Pharmacol. 2008 Jan 15;75(2):457-67. Epub 2007 Sep 1.PMID: 17945190 [PubMed - indexed for MEDLINE]Related articles

Inhibition of insulin-stimulated glycogen synthesis by 5-aminoimidasole-4-carboxamide-1-beta-d-ribofuranoside-induced adenosine 5'-monophosphate-activated protein kinase activation: interactions with Akt, glycogen synthase kinase 3-3alpha/beta, and glycogen synthase in isolated rat soleus muscle.

Fediuc S, Gaidhu MP, Ceddia RB.

Endocrinology. 2006 Nov;147(11):5170-7. Epub 2006 Jul 27.PMID: 16873531 [PubMed - indexed for MEDLINE]Related articlesFree article

5-Aminoimidazole-4-carboxamide 1-beta -D-ribofuranoside (AICAR) stimulates myocardial glycogenolysis by allosteric mechanisms.

Longnus SL, Wambolt RB, Parsons HL, Brownsey RW, Allard MF.

Am J Physiol Regul Integr Comp Physiol. 2003 Apr;284(4):R936-44.PMID: 12626360 [PubMed - indexed for MEDLINE]Related articles

The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.

Jørgensen SB, Nielsen JN, Birk JB, Olsen GS, Viollet B, Andreelli F, Schjerling P, Vaulont S, Hardie DG, Hansen BF, Richter EA, Wojtaszewski JF.

Diabetes. 2004 Dec;53(12):3074-81.PMID: 15561936 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle-specific overexpression of wild type and R225Q mutant AMP-activated protein kinase gamma3-subunit differentially regulates glycogen accumulation.

Yu H, Hirshman MF, Fujii N, Pomerleau JM, Peter LE, Goodyear LJ.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E557-65. Epub 2006 Apr 25.PMID: 16638825 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin signalling downstream of protein kinase B is potentiated by 5'AMP-activated protein kinase in rat hearts in vivo.

Longnus SL, Ségalen C, Giudicelli J, Sajan MP, Farese RV, Van Obberghen E.

Diabetologia. 2005 Dec;48(12):2591-601. Epub 2005 Nov 11.PMID: 16283248 [PubMed - indexed for MEDLINE]Related articles

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-induced AMP-activated protein kinase phosphorylation inhibits basal and insulin-stimulated glucose uptake, lipid synthesis, and fatty acid oxidation in isolated rat adipocytes.

Gaidhu MP, Fediuc S, Ceddia RB.

J Biol Chem. 2006 Sep 8;281(36):25956-64. Epub 2006 Jul 1.PMID: 16816404 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle.

Jørgensen SB, Wojtaszewski JF, Viollet B, Andreelli F, Birk JB, Hellsten Y, Schjerling P, Vaulont S, Neufer PD, Richter EA, Pilegaard H.

FASEB J. 2005 Jul;19(9):1146-8. Epub 2005 May 5.PMID: 15878932 [PubMed - indexed for MEDLINE]Related articlesFree article

Critical role of 5'-AMP-activated protein kinase in the stimulation of glucose transport in response to inhibition of oxidative phosphorylation.

Jing M, Ismail-Beigi F.

Am J Physiol Cell Physiol. 2007 Jan;292(1):C477-87. Epub 2006 Aug 30.PMID: 16943243 [PubMed - indexed for MEDLINE]Related articlesFree article

alpha2 Isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-d-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle.

Nakano M, Hamada T, Hayashi T, Yonemitsu S, Miyamoto L, Toyoda T, Tanaka S, Masuzaki H, Ebihara K, Ogawa Y, Hosoda K, Inoue G, Yoshimasa Y, Otaka A, Fushiki T, Nakao K.

Metabolism. 2006 Mar;55(3):300-8.PMID: 16483872 [PubMed - indexed for MEDLINE]Related articles

Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

Mukhtar MH, Payne VA, Arden C, Harbottle A, Khan S, Lange AJ, Agius L.

Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R766-74. Epub 2008 Jan 16.PMID: 18199594 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3.

King TD, Song L, Jope RS.

Biochem Pharmacol. 2006 May 28;71(11):1637-47. Epub 2006 Mar 10.PMID: 16620785 [PubMed - indexed for MEDLINE]Related articlesFree article

5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK.

Walker J, Jijon HB, Diaz H, Salehi P, Churchill T, Madsen KL.

Biochem J. 2005 Jan 15;385(Pt 2):485-91.PMID: 15367103 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart.

Li J, Miller EJ, Ninomiya-Tsuji J, Russell RR 3rd, Young LH.

Circ Res. 2005 Oct 28;97(9):872-9. Epub 2005 Sep 22.PMID: 16179588 [PubMed - indexed for MEDLINE]Related articlesFree article

Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells.

Woollhead AM, Scott JW, Hardie DG, Baines DL.

J Physiol. 2005 Aug 1;566(Pt 3):781-92. Epub 2005 May 26.PMID: 15919715 [PubMed - indexed for MEDLINE]Related articlesFree article