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    Results: 1 to 20 of 199

    1.

    Proinsulin 2 knockout NOD mice: a model for genetic variation of insulin gene expression in type 1 diabetes.

    Dubois-Lafforgue D, Mogenet L, Thébault K, Jami J, Krief P, Boitard C.

    Diabetes. 2002 Dec;51 Suppl 3:S489-93.PMID: 12475795 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice.

    Thébault-Baumont K, Dubois-Laforgue D, Krief P, Briand JP, Halbout P, Vallon-Geoffroy K, Morin J, Laloux V, Lehuen A, Carel JC, Jami J, Muller S, Boitard C.

    J Clin Invest. 2003 Mar;111(6):851-7.PMID: 12639991 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Thymic expression of mutated B16:A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 (thymic expressed insulin) knockout.

    Nakayama M, Babaya N, Miao D, Sikora K, Elliott JF, Eisenbarth GS.

    J Autoimmun. 2005 Nov;25(3):193-8. Epub 2005 Nov 14.PMID: 16289958 [PubMed - indexed for MEDLINE]Related articles

    4.

    Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse.

    Moriyama H, Abiru N, Paronen J, Sikora K, Liu E, Miao D, Devendra D, Beilke J, Gianani R, Gill RG, Eisenbarth GS.

    Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10376-81. Epub 2003 Aug 18.PMID: 12925730 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    A new model of insulin-deficient diabetes: male NOD mice with a single copy of Ins1 and no Ins2.

    Babaya N, Nakayama M, Moriyama H, Gianani R, Still T, Miao D, Yu L, Hutton JC, Eisenbarth GS.

    Diabetologia. 2006 Jun;49(6):1222-8. Epub 2006 Apr 13.PMID: 16612590 [PubMed - indexed for MEDLINE]Related articles

    6.

    Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.

    Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D, Yu L, Wegmann DR, Hutton JC, Elliott JF, Eisenbarth GS.

    Nature. 2005 May 12;435(7039):220-3.PMID: 15889095 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Transplantation of bone marrow genetically engineered to express proinsulin II protects against autoimmune insulitis in NOD mice.

    Chan J, Clements W, Field J, Nasa Z, Lock P, Yap F, Toh BH, Alderuccio F.

    J Gene Med. 2006 Nov;8(11):1281-90.PMID: 16989008 [PubMed - indexed for MEDLINE]Related articles

    8.

    Long-term prevention of diabetes and marked suppression of insulin autoantibodies and insulitis in mice lacking native insulin B9-23 sequence.

    Nakayama M, Babaya N, Miao D, Gianani R, Liu E, Elliott JF, Eisenbarth GS.

    Ann N Y Acad Sci. 2006 Oct;1079:122-9.PMID: 17130542 [PubMed - indexed for MEDLINE]Related articles

    9.

    Intravenous administration of proinsulin 1 or 2-expressing fiber-mutant recombinant adenovirus vector protects against the development of diabetes in NOD mice.

    Yamada K, Moriyama H, Okumachi Y, Arai T, Kameno M, Kishi M, Yasuda H, Hara K, Yokono K, Nagata M.

    Ann N Y Acad Sci. 2008 Dec;1150:183-6.PMID: 19120291 [PubMed - indexed for MEDLINE]Related articles

    10.

    Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout.

    Jasinski JM, Yu L, Nakayama M, Li MM, Lipes MA, Eisenbarth GS, Liu E.

    Diabetes. 2006 Jul;55(7):1978-84.PMID: 16804066 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Development of autoimmune diabetes in glutamic acid decarboxylase 65 (GAD65) knockout NOD mice.

    Yamamoto T, Yamato E, Tashiro F, Sato T, Noso S, Ikegami H, Tamura S, Yanagawa Y, Miyazaki JI.

    Diabetologia. 2004 Feb;47(2):221-4. Epub 2003 Dec 16.PMID: 14676944 [PubMed - indexed for MEDLINE]Related articles

    12.

    Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes.

    Jaeckel E, Lipes MA, von Boehmer H.

    Nat Immunol. 2004 Oct;5(10):1028-35. Epub 2004 Sep 19. Erratum in: Nat Immunol. 2004 Nov;5(11):1190. Nat Immunol. 2005 Feb;6(2):219. PMID: 15378058 [PubMed - indexed for MEDLINE]Related articles

    13.

    Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes.

    Chentoufi AA, Polychronakos C.

    Diabetes. 2002 May;51(5):1383-90. Erratum in: Diabetes 2002 Aug;51(8):2665. PMID: 11978634 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Survival of an islet allograft deficient in iNOS after implantation into diabetic NOD mice.

    Börjesson A, Andersson AK, Sandler S.

    Cell Transplant. 2006;15(8-9):769-75.PMID: 17269447 [PubMed - indexed for MEDLINE]Related articles

    15.

    Intranasal vaccination with proinsulin DNA induces regulatory CD4+ T cells that prevent experimental autoimmune diabetes.

    Every AL, Kramer DR, Mannering SI, Lew AM, Harrison LC.

    J Immunol. 2006 Apr 15;176(8):4608-15.PMID: 16585551 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Insulin gene transfer enhances the function of human islet grafts.

    Deng S, Vatamaniuk M, Lian MM, Doliba N, Wang J, Bell E, Wolf B, Raper S, Matschinsky FM, Markmann JF.

    Diabetologia. 2003 Mar;46(3):386-93. Epub 2003 Mar 7.PMID: 12687337 [PubMed - indexed for MEDLINE]Related articles

    17.

    Insulin2 gene (Ins2) transcription by NOD bone marrow-derived cells does not influence autoimmune diabetes development in NOD-Ins2 knockout mice.

    Martin-Pagola A, Pileggi A, Zahr E, Vendrame F, Damaris Molano R, Snowhite I, Ricordi C, Eisenbarth GS, Nakayama M, Pugliese A.

    Scand J Immunol. 2009 Nov;70(5):439-46.PMID: 19874548 [PubMed - indexed for MEDLINE]Related articles

    18.

    Interleukin-4 deficiency does not exacerbate disease in NOD mice.

    Wang B, Gonzalez A, Höglund P, Katz JD, Benoist C, Mathis D.

    Diabetes. 1998 Aug;47(8):1207-11.PMID: 9703318 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice.

    Moriyama H, Nagata M, Arai T, Okumachi Y, Yamada K, Kotani R, Yasuda H, Hara K, Yokono K.

    Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S155-60. Epub 2007 Apr 24.PMID: 17459508 [PubMed - indexed for MEDLINE]Related articles

    20.

    Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice.

    Kubosaki A, Gross S, Miura J, Saeki K, Zhu M, Nakamura S, Hendriks W, Notkins AL.

    Diabetes. 2004 Jul;53(7):1684-91.PMID: 15220191 [PubMed - indexed for MEDLINE]Related articlesFree article

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