PubMed

Two generations of insulinotropic imidazoline compounds.

Efendic S, Efanov AM, Berggren PO, Zaitsev SV.

Diabetes. 2002 Dec;51 Suppl 3:S448-54. Review.PMID: 12475789 [PubMed - indexed for MEDLINE]Related articlesFree article

The novel imidazoline compound BL11282 potentiates glucose-induced insulin secretion in pancreatic beta-cells in the absence of modulation of K(ATP) channel activity.

Efanov AM, Zaitsev SV, Mest HJ, Raap A, Appelskog IB, Larsson O, Berggren PO, Efendic S.

Diabetes. 2001 Apr;50(4):797-802.PMID: 11289044 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulinotropic activity of the imidazoline derivative RX871024 in the diabetic GK rat.

Efanov AM, Appelskog IB, Abdel-Halim SM, Khan A, Bränström R, Larsson O, Ostenson CG, Mest HJ, Berggren PO, Efendic S, Zaitsev SV.

Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E117-24.PMID: 11739091 [PubMed - indexed for MEDLINE]Related articlesFree article

Imidazoline compounds stimulate insulin release by inhibition of K(ATP) channels and interaction with the exocytotic machinery.

Zaitsev SV, Efanov AM, Efanova IB, Larsson O, Ostenson CG, Gold G, Berggren PO, Efendić S.

Diabetes. 1996 Nov;45(11):1610-8.PMID: 8866568 [PubMed - indexed for MEDLINE]Related articles

The imidazoline RX871024 stimulates insulin secretion in pancreatic beta-cells from mice deficient in K(ATP) channel function.

Efanov AM, Høy M, Bränström R, Zaitsev SV, Magnuson MA, Efendic S, Gromada J, Berggren PO.

Biochem Biophys Res Commun. 2001 Jun 22;284(4):918-22.PMID: 11409880 [PubMed - indexed for MEDLINE]Related articles

Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells.

Høy M, Olsen HL, Andersen HS, Bokvist K, Buschard K, Hansen J, Jacobsen P, Petersen JS, Rorsman P, Gromada J.

Eur J Pharmacol. 2003 Apr 11;466(1-2):213-21.PMID: 12679159 [PubMed - indexed for MEDLINE]Related articles

Different modes of action of the imidazoline compound RX871024 in pancreatic beta-cells. Blocking of K+ channels, mobilization of Ca2+ from endoplasmic reticulum, and interaction with exocytotic machinery.

Zaitsev SV, Efanov AM, Raap A, Efanova IB, Schloos J, Steckel-Hamann B, Larsson O, Ostenson CG, Berggren PO, Mest HJ, Efendic S.

Ann N Y Acad Sci. 1999 Jun 21;881:241-52.PMID: 10415922 [PubMed - indexed for MEDLINE]Related articles

Imidazoline RX871024 raises diacylglycerol levels in rat pancreatic islets.

Efanov AM, Zaitsev SV, Berggren PO, Mest HJ, Efendic S.

Biochem Biophys Res Commun. 2001 Mar;281(5):1070-3.PMID: 11243843 [PubMed - indexed for MEDLINE]Related articles

Arachidonic acid signaling is involved in the mechanism of imidazoline-induced KATP channel-independent stimulation of insulin secretion.

Sharoyko VV, Zaitseva II, Leibiger B, Efendić S, Berggren PO, Zaitsev SV.

Cell Mol Life Sci. 2007 Nov;64(22):2985-93.PMID: 17922229 [PubMed - indexed for MEDLINE]Related articles

Multiple effector pathways regulate the insulin secretory response to the imidazoline RX871024 in isolated rat pancreatic islets.

Mourtada M, Chan SL, Smith SA, Morgan NG.

Br J Pharmacol. 1999 Jul;127(5):1279-87.PMID: 10455276 [PubMed - indexed for MEDLINE]Related articlesFree article

The imidazoline NNC77-0020 affects glucose-dependent insulin, glucagon and somatostatin secretion in mouse pancreatic islets.

Høy M, Olsen HL, Bokvist K, Petersen JS, Gromada J.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Oct;368(4):284-93. Epub 2003 Sep 6.PMID: 13680090 [PubMed - indexed for MEDLINE]Related articles

Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans.

Mourtada M, Smith SA, Morgan NG.

Eur J Pharmacol. 1998 Jun 5;350(2-3):251-8.PMID: 9696415 [PubMed - indexed for MEDLINE]Related articles

Ca2+-secretion coupling is impaired in diabetic Goto Kakizaki rats.

Rose T, Efendic S, Rupnik M.

J Gen Physiol. 2007 Jun;129(6):493-508.PMID: 17535961 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose dependence of imidazoline-induced insulin secretion: different characteristics of two ATP-Sensitive K+ channel-blocking compounds.

Bleck C, Wienbergen A, Rustenbeck I.

Diabetes. 2004 Dec;53 Suppl 3:S135-9.PMID: 15561901 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of imidazoline derivative RX871024 on insulin, glucagon, and somatostatin secretion from isolated perfused rat pancreas.

Efanova IB, Zaitsev SV, Efanov AM, Ostenson C, Raap A, Mest H, Berggren P, Efendi.

Biochem Biophys Res Commun. 1998 Nov 9;252(1):162-5.PMID: 9813163 [PubMed - indexed for MEDLINE]Related articles

Carbachol restores insulin release in diabetic GK rat islets by mechanisms largely involving hydrolysis of diacylglycerol and direct interaction with the exocytotic machinery.

Guenifi A, Simonsson E, Karlsson S, Ahrén B, Abdel-Halim SM.

Pancreas. 2001 Mar;22(2):164-71.PMID: 11249071 [PubMed - indexed for MEDLINE]Related articles

Signaling and sites of interaction for RX-871024 and sulfonylurea in the stimulation of insulin release.

Efanov AM, Zaitsev SV, Efanova IB, Zhu S, Ostenson CG, Berggren PO, Efendić S.

Am J Physiol. 1998 Apr;274(4 Pt 1):E751-7.PMID: 9575838 [PubMed - indexed for MEDLINE]Related articlesFree article

Clotrimazole and efaroxan stimulate insulin secretion by different mechanisms in rat pancreatic islets.

Chan SL, Pallett AL, Morgan NG.

Naunyn Schmiedebergs Arch Pharmacol. 1997 Dec;356(6):763-8.PMID: 9453462 [PubMed - indexed for MEDLINE]Related articles

Distinct effect of diazoxide on insulin secretion stimulated by protein kinase A and protein kinase C in rat pancreatic islets.

Shen ZP, Nishimura M, Tsuura Y, Fujimoto S, Mukai E, Yamada Y, Seino Y.

Diabetes Res Clin Pract. 2001 Jul;53(1):9-16.PMID: 11378208 [PubMed - indexed for MEDLINE]Related articles

Imidazolines and the pancreatic B-cell. Actions and binding sites.

Rustenbeck I, Köpp M, Ratzka P, Leupolt L, Hasselblatt A.

Ann N Y Acad Sci. 1999 Jun 21;881:229-40.PMID: 10415921 [PubMed - indexed for MEDLINE]Related articles