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    Results: 1 to 20 of 185

    1.

    Genetic manipulations of fatty acid metabolism in beta-cells are associated with dysregulated insulin secretion.

    Eto K, Yamashita T, Matsui J, Terauchi Y, Noda M, Kadowaki T.

    Diabetes. 2002 Dec;51 Suppl 3:S414-20. Review.PMID: 12475784 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c.

    Yamashita T, Eto K, Okazaki Y, Yamashita S, Yamauchi T, Sekine N, Nagai R, Noda M, Kadowaki T.

    Endocrinology. 2004 Aug;145(8):3566-77. Epub 2004 Apr 1.PMID: 15059954 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Impact of PPARgamma overexpression and activation on pancreatic islet gene expression profile analyzed with oligonucleotide microarrays.

    Parton LE, Diraison F, Neill SE, Ghosh SK, Rubino MA, Bisi JE, Briscoe CP, Rutter GA.

    Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E390-404. Epub 2004 May 4.PMID: 15126236 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).

    Diraison F, Parton L, Ferré P, Foufelle F, Briscoe CP, Leclerc I, Rutter GA.

    Biochem J. 2004 Mar 15;378(Pt 3):769-78.PMID: 14690455 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells.

    Takahashi A, Motomura K, Kato T, Yoshikawa T, Nakagawa Y, Yahagi N, Sone H, Suzuki H, Toyoshima H, Yamada N, Shimano H.

    Diabetes. 2005 Feb;54(2):492-9.PMID: 15677507 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Elevated insulin secretion from liver X receptor-activated pancreatic beta-cells involves increased de novo lipid synthesis and triacylglyceride turnover.

    Green CD, Jump DB, Olson LK.

    Endocrinology. 2009 Jun;150(6):2637-45. Epub 2009 Feb 19.PMID: 19228891 [PubMed - indexed for MEDLINE]Related articles

    7.

    Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition.

    Patanè G, Anello M, Piro S, Vigneri R, Purrello F, Rabuazzo AM.

    Diabetes. 2002 Sep;51(9):2749-56.PMID: 12196468 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

    Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB.

    J Biol Chem. 2004 Dec 3;279(49):51049-56. Epub 2004 Sep 23.PMID: 15448158 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.

    Kato T, Shimano H, Yamamoto T, Ishikawa M, Kumadaki S, Matsuzaka T, Nakagawa Y, Yahagi N, Nakakuki M, Hasty AH, Takeuchi Y, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Sone H, Yamada N.

    Diabetes. 2008 Sep;57(9):2382-92. Epub 2008 May 5.PMID: 18458149 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    In vitro suppression of the lipogenic pathway by the nonnucleoside reverse transcriptase inhibitor efavirenz in 3T3 and human preadipocytes or adipocytes.

    El Hadri K, Glorian M, Monsempes C, Dieudonné MN, Pecquery R, Giudicelli Y, Andreani M, Dugail I, Fève B.

    J Biol Chem. 2004 Apr 9;279(15):15130-41. Epub 2004 Jan 13.PMID: 14722061 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet.

    Matsui J, Terauchi Y, Kubota N, Takamoto I, Eto K, Yamashita T, Komeda K, Yamauchi T, Kamon J, Kita S, Noda M, Kadowaki T.

    Diabetes. 2004 Nov;53(11):2844-54.PMID: 15504964 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.

    Horton JD, Shimomura I, Ikemoto S, Bashmakov Y, Hammer RE.

    J Biol Chem. 2003 Sep 19;278(38):36652-60. Epub 2003 Jul 10.PMID: 12855691 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Effects of dietary fatty acids on insulin sensitivity and secretion.

    Manco M, Calvani M, Mingrone G.

    Diabetes Obes Metab. 2004 Nov;6(6):402-13. Review.PMID: 15479216 [PubMed - indexed for MEDLINE]Related articles

    14.

    Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

    Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F.

    Diabetes. 2001 Apr;50(4):803-9.PMID: 11289045 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action.

    Chan CB, De Leo D, Joseph JW, McQuaid TS, Ha XF, Xu F, Tsushima RG, Pennefather PS, Salapatek AM, Wheeler MB.

    Diabetes. 2001 Jun;50(6):1302-10.PMID: 11375330 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Glucose induces de novo lipogenesis in rat muscle satellite cells through a sterol-regulatory-element-binding-protein-1c-dependent pathway.

    Guillet-Deniau I, Pichard AL, Koné A, Esnous C, Nieruchalski M, Girard J, Prip-Buus C.

    J Cell Sci. 2004 Apr 15;117(Pt 10):1937-44. Epub 2004 Mar 23.PMID: 15039461 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Overexpression of repressive cAMP response element modulators in high glucose and fatty acid-treated rat islets. A common mechanism for glucose toxicity and lipotoxicity?

    Zhou YP, Marlen K, Palma JF, Schweitzer A, Reilly L, Gregoire FM, Xu GG, Blume JE, Johnson JD.

    J Biol Chem. 2003 Dec 19;278(51):51316-23. Epub 2003 Oct 8.PMID: 14534319 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Sterol regulatory element-binding protein-1c and pancreatic beta-cell dysfunction.

    Shimano H, Amemiya-Kudo M, Takahashi A, Kato T, Ishikawa M, Yamada N.

    Diabetes Obes Metab. 2007 Nov;9 Suppl 2:133-9.PMID: 17919187 [PubMed - indexed for MEDLINE]Related articles

    19.

    Impaired lipid accumulation by trans10, cis12 CLA during adipocyte differentiation is dependent on timing and length of treatment.

    Granlund L, Pedersen JI, Nebb HI.

    Biochim Biophys Acta. 2005 Feb 21;1687(1-3):11-22.PMID: 15708349 [PubMed - indexed for MEDLINE]Related articles

    20.

    Limited role for SREBP-1c in defective glucose-induced insulin secretion from Zucker diabetic fatty rat islets: a functional and gene profiling analysis.

    Parton LE, McMillen PJ, Shen Y, Docherty E, Sharpe E, Diraison F, Briscoe CP, Rutter GA.

    Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E982-94. Epub 2006 Jun 13.PMID: 16772326 [PubMed - indexed for MEDLINE]Related articlesFree article

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