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Regulation of pancreatic beta-cell glucokinase: from basics to therapeutics.

Matschinsky FM.

Diabetes. 2002 Dec;51 Suppl 3:S394-404. Review.PMID: 12475782 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell-biological assessment of human glucokinase mutants causing maturity-onset diabetes of the young type 2 (MODY-2) or glucokinase-linked hyperinsulinaemia (GK-HI).

Burke CV, Buettger CW, Davis EA, McClane SJ, Matschinsky FM, Raper SE.

Biochem J. 1999 Sep 1;342 ( Pt 2):345-52.PMID: 10455021 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase and glucose homeostasis: proven concepts and new ideas.

Zelent D, Najafi H, Odili S, Buettger C, Weik-Collins H, Li C, Doliba N, Grimsby J, Matschinsky FM.

Biochem Soc Trans. 2005 Feb;33(Pt 1):306-10.PMID: 15667334 [PubMed - indexed for MEDLINE]Related articles

Cell-specific roles of glucokinase in glucose homeostasis.

Postic C, Shiota M, Magnuson MA.

Recent Prog Horm Res. 2001;56:195-217. Review.PMID: 11237213 [PubMed - indexed for MEDLINE]Related articlesFree article

Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm.

Matschinsky FM.

Diabetes. 1996 Feb;45(2):223-41. Review.PMID: 8549869 [PubMed - indexed for MEDLINE]Related articles

Small molecule glucokinase activators as novel anti-diabetic agents.

Leighton B, Atkinson A, Coghlan MP.

Biochem Soc Trans. 2005 Apr;33(Pt 2):371-4. Review.PMID: 15787609 [PubMed - indexed for MEDLINE]Related articles

The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy.

Matschinsky FM, Magnuson MA, Zelent D, Jetton TL, Doliba N, Han Y, Taub R, Grimsby J.

Diabetes. 2006 Jan;55(1):1-12. Review.PMID: 16380470 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel glucokinase activator modulates pancreatic islet and hepatocyte function.

Efanov AM, Barrett DG, Brenner MB, Briggs SL, Delaunois A, Durbin JD, Giese U, Guo H, Radloff M, Gil GS, Sewing S, Wang Y, Weichert A, Zaliani A, Gromada J.

Endocrinology. 2005 Sep;146(9):3696-701. Epub 2005 May 26.PMID: 15919746 [PubMed - indexed for MEDLINE]Related articlesFree article

Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme.

Liang Y, Kesavan P, Wang LQ, Niswender K, Tanizawa Y, Permutt MA, Magnuson MA, Matschinsky FM.

Biochem J. 1995 Jul 1;309 ( Pt 1):167-73.PMID: 7619052 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.

Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA.

J Biol Chem. 1999 Jan 1;274(1):305-15.PMID: 9867845 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of glucokinase mutations associated with maturity-onset diabetes of the young type 2 (MODY-2): different glucokinase defects lead to a common phenotype.

Miller SP, Anand GR, Karschnia EJ, Bell GI, LaPorte DC, Lange AJ.

Diabetes. 1999 Aug;48(8):1645-51.PMID: 10426385 [PubMed - indexed for MEDLINE]Related articlesFree article

Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion.

Efrat S, Leiser M, Wu YJ, Fusco-DeMane D, Emran OA, Surana M, Jetton TL, Magnuson MA, Weir G, Fleischer N.

Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2051-5.PMID: 7510884 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase, glucose homeostasis, and diabetes mellitus.

Matschinsky FM.

Curr Diab Rep. 2005 Jun;5(3):171-6. Review.PMID: 15929862 [PubMed - indexed for MEDLINE]Related articles

Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose.

Terauchi Y, Sakura H, Yasuda K, Iwamoto K, Takahashi N, Ito K, Kasai H, Suzuki H, Ueda O, Kamada N, et al.

J Biol Chem. 1995 Dec 22;270(51):30253-6.PMID: 8530440 [PubMed - indexed for MEDLINE]Related articlesFree article

An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism.

Futamura M, Hosaka H, Kadotani A, Shimazaki H, Sasaki K, Ohyama S, Nishimura T, Eiki J, Nagata Y.

J Biol Chem. 2006 Dec 8;281(49):37668-74. Epub 2006 Oct 6.PMID: 17028192 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis.

Davis EA, Cuesta-Muñoz A, Raoul M, Buettger C, Sweet I, Moates M, Magnuson MA, Matschinsky FM.

Diabetologia. 1999 Oct;42(10):1175-86.PMID: 10525657 [PubMed - indexed for MEDLINE]Related articles

Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation.

Cuesta-Muñoz AL, Huopio H, Otonkoski T, Gomez-Zumaquero JM, Näntö-Salonen K, Rahier J, López-Enriquez S, García-Gimeno MA, Sanz P, Soriguer FC, Laakso M.

Diabetes. 2004 Aug;53(8):2164-8.PMID: 15277402 [PubMed - indexed for MEDLINE]Related articlesFree article

Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.

Gloyn AL, Odili S, Zelent D, Buettger C, Castleden HA, Steele AM, Stride A, Shiota C, Magnuson MA, Lorini R, d'Annunzio G, Stanley CA, Kwagh J, van Schaftingen E, Veiga-da-Cunha M, Barbetti F, Dunten P, Han Y, Grimsby J, Taub R, Ellard S, Hattersley AT, Matschinsky FM.

J Biol Chem. 2005 Apr 8;280(14):14105-13. Epub 2005 Jan 25.PMID: 15677479 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants.

Takeda J, Gidh-Jain M, Xu LZ, Froguel P, Velho G, Vaxillaire M, Cohen D, Shimada F, Makino H, Nishi S, et al.

J Biol Chem. 1993 Jul 15;268(20):15200-4.PMID: 8325892 [PubMed - indexed for MEDLINE]Related articlesFree article

Allosteric activators of glucokinase: potential role in diabetes therapy.

Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF.

Science. 2003 Jul 18;301(5631):370-3.PMID: 12869762 [PubMed - indexed for MEDLINE]Related articlesFree article