PubMed

Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach.

Newgard CB, Lu D, Jensen MV, Schissler J, Boucher A, Burgess S, Sherry AD.

Diabetes. 2002 Dec;51 Suppl 3:S389-93. Review.PMID: 12475781 [PubMed - indexed for MEDLINE]Related articlesFree article

A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion.

Ronnebaum SM, Ilkayeva O, Burgess SC, Joseph JW, Lu D, Stevens RD, Becker TC, Sherry AD, Newgard CB, Jensen MV.

J Biol Chem. 2006 Oct 13;281(41):30593-602. Epub 2006 Aug 15.PMID: 16912049 [PubMed - indexed for MEDLINE]Related articlesFree article

Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.

Jensen MV, Joseph JW, Ilkayeva O, Burgess S, Lu D, Ronnebaum SM, Odegaard M, Becker TC, Sherry AD, Newgard CB.

J Biol Chem. 2006 Aug 4;281(31):22342-51. Epub 2006 Jun 1.PMID: 16740637 [PubMed - indexed for MEDLINE]Related articlesFree article

A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion.

Brennan L, Shine A, Hewage C, Malthouse JP, Brindle KM, McClenaghan N, Flatt PR, Newsholme P.

Diabetes. 2002 Jun;51(6):1714-21.PMID: 12031957 [PubMed - indexed for MEDLINE]Related articlesFree article

13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS).

Lu D, Mulder H, Zhao P, Burgess SC, Jensen MV, Kamzolova S, Newgard CB, Sherry AD.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2708-13.PMID: 11880625 [PubMed - indexed for MEDLINE]Related articlesFree article

Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets.

Fransson U, Rosengren AH, Schuit FC, Renström E, Mulder H.

Diabetologia. 2006 Jul;49(7):1578-86. Epub 2006 Apr 26.PMID: 16752176 [PubMed - indexed for MEDLINE]Related articles

Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells.

Diao J, Asghar Z, Chan CB, Wheeler MB.

J Biol Chem. 2005 Sep 30;280(39):33487-96. Epub 2005 Jul 14.PMID: 16027126 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic cycling in control of glucose-stimulated insulin secretion.

Jensen MV, Joseph JW, Ronnebaum SM, Burgess SC, Sherry AD, Newgard CB.

Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1287-97. Epub 2008 Aug 26. Review.PMID: 18728221 [PubMed - indexed for MEDLINE]Related articles

Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets.

Ronnebaum SM, Jensen MV, Hohmeier HE, Burgess SC, Zhou YP, Qian S, MacNeil D, Howard A, Thornberry N, Ilkayeva O, Lu D, Sherry AD, Newgard CB.

J Biol Chem. 2008 Oct 24;283(43):28909-17. Epub 2008 Aug 28.PMID: 18755687 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion.

Piston DW, Knobel SM, Postic C, Shelton KD, Magnuson MA.

J Biol Chem. 1999 Jan 8;274(2):1000-4.PMID: 9873043 [PubMed - indexed for MEDLINE]Related articlesFree article

Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue.

Boucher A, Lu D, Burgess SC, Telemaque-Potts S, Jensen MV, Mulder H, Wang MY, Unger RH, Sherry AD, Newgard CB.

J Biol Chem. 2004 Jun 25;279(26):27263-71. Epub 2004 Apr 7.PMID: 15073188 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.

Nolan CJ, Leahy JL, Delghingaro-Augusto V, Moibi J, Soni K, Peyot ML, Fortier M, Guay C, Lamontagne J, Barbeau A, Przybytkowski E, Joly E, Masiello P, Wang S, Mitchell GA, Prentki M.

Diabetologia. 2006 Sep;49(9):2120-30. Epub 2006 Jul 26.PMID: 16868750 [PubMed - indexed for MEDLINE]Related articles

Protein prenylation in glucose-induced insulin secretion from the pancreatic islet beta cell: a perspective.

Kowluru A.

J Cell Mol Med. 2008 Jan-Feb;12(1):164-73. Epub 2007 Dec 5. Review.PMID: 18053094 [PubMed - indexed for MEDLINE]Related articles

Nuclear factor-{kappa}B activity in {beta}-cells is required for glucose-stimulated insulin secretion.

Norlin S, Ahlgren U, Edlund H.

Diabetes. 2005 Jan;54(1):125-32.PMID: 15616019 [PubMed - indexed for MEDLINE]Related articlesFree article

Rho guanosine diphosphate-dissociation inhibitor plays a negative modulatory role in glucose-stimulated insulin secretion.

Kowluru A, Veluthakal R.

Diabetes. 2005 Dec;54(12):3523-9.PMID: 16306371 [PubMed - indexed for MEDLINE]Related articlesFree article

Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion.

Herrero L, Rubí B, Sebastián D, Serra D, Asins G, Maechler P, Prentki M, Hegardt FG.

Diabetes. 2005 Feb;54(2):462-71.PMID: 15677504 [PubMed - indexed for MEDLINE]Related articlesFree article

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.

Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG, Newgard CB.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7297-302. Epub 2005 May 9.PMID: 15883383 [PubMed - indexed for MEDLINE]Related articlesFree article

Tacrolimus impairment of insulin secretion in isolated rat islets occurs at multiple distal sites in stimulus-secretion coupling.

Uchizono Y, Iwase M, Nakamura U, Sasaki N, Goto D, Iida M.

Endocrinology. 2004 May;145(5):2264-72. Epub 2004 Feb 12.PMID: 14962991 [PubMed - indexed for MEDLINE]Related articlesFree article

PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells.

Hashimoto N, Kido Y, Uchida T, Matsuda T, Suzuki K, Inoue H, Matsumoto M, Ogawa W, Maeda S, Fujihara H, Ueta Y, Uchiyama Y, Akimoto K, Ohno S, Noda T, Kasuga M.

J Clin Invest. 2005 Jan;115(1):138-45.PMID: 15630453 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells.

Ravnskjaer K, Boergesen M, Rubi B, Larsen JK, Nielsen T, Fridriksson J, Maechler P, Mandrup S.

Endocrinology. 2005 Aug;146(8):3266-76. Epub 2005 May 5.PMID: 15878969 [PubMed - indexed for MEDLINE]Related articlesFree article