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    Results: 1 to 20 of 108

    1.

    Nucleotide sensitivity of pancreatic ATP-sensitive potassium channels and type 2 diabetes.

    Schwanstecher C, Schwanstecher M.

    Diabetes. 2002 Dec;51 Suppl 3:S358-62. Review.PMID: 12475775 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    The common single nucleotide polymorphism E23K in K(IR)6.2 sensitizes pancreatic beta-cell ATP-sensitive potassium channels toward activation through nucleoside diphosphates.

    Schwanstecher C, Neugebauer B, Schulz M, Schwanstecher M.

    Diabetes. 2002 Dec;51 Suppl 3:S363-7.PMID: 12475776 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels.

    Schwanstecher C, Meyer U, Schwanstecher M.

    Diabetes. 2002 Mar;51(3):875-9.PMID: 11872696 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Single nucleotide polymorphisms in K(ATP) channels: muscular impact on type 2 diabetes.

    Li L, Shi Y, Wang X, Shi W, Jiang C.

    Diabetes. 2005 May;54(5):1592-7.PMID: 15855351 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARgamma Pro12Ala variant.

    Love-Gregory L, Wasson J, Lin J, Skolnick G, Suarez B, Permutt MA.

    Diabetologia. 2003 Jan;46(1):136-7. No abstract available. PMID: 12643262 [PubMed - indexed for MEDLINE]Related articles

    6.

    Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.

    Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM.

    Diabetes. 2003 Feb;52(2):568-72.PMID: 12540637 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    ABCC8 and ABCC9: ABC transporters that regulate K+ channels.

    Bryan J, Muñoz A, Zhang X, Düfer M, Drews G, Krippeit-Drews P, Aguilar-Bryan L.

    Pflugers Arch. 2007 Feb;453(5):703-18. Epub 2006 Aug 8. Review.PMID: 16897043 [PubMed - indexed for MEDLINE]Related articles

    8.

    Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.

    Florez JC, Burtt N, de Bakker PI, Almgren P, Tuomi T, Holmkvist J, Gaudet D, Hudson TJ, Schaffner SF, Daly MJ, Hirschhorn JN, Groop L, Altshuler D.

    Diabetes. 2004 May;53(5):1360-8.PMID: 15111507 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes?

    Riedel MJ, Boora P, Steckley D, de Vries G, Light PE.

    Diabetes. 2003 Oct;52(10):2630-5.PMID: 14514649 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection.

    Koster JC, Permutt MA, Nichols CG.

    Diabetes. 2005 Nov;54(11):3065-72. Review.PMID: 16249427 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Focus on Kir6.2: a key component of the ATP-sensitive potassium channel.

    Haider S, Antcliff JF, Proks P, Sansom MS, Ashcroft FM.

    J Mol Cell Cardiol. 2005 Jun;38(6):927-36. Review.PMID: 15910877 [PubMed - indexed for MEDLINE]Related articles

    12.

    Activating mutations in the ABCC8 gene in neonatal diabetes mellitus.

    Babenko AP, Polak M, Cavé H, Busiah K, Czernichow P, Scharfmann R, Bryan J, Aguilar-Bryan L, Vaxillaire M, Froguel P.

    N Engl J Med. 2006 Aug 3;355(5):456-66.PMID: 16885549 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    A conserved inhibitory and differential stimulatory action of nucleotides on K(IR)6.0/SUR complexes is essential for excitation-metabolism coupling by K(ATP) channels.

    Babenko AP, Bryan J.

    J Biol Chem. 2001 Dec 28;276(52):49083-92. Epub 2001 Oct 22.PMID: 11673467 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects.

    Yokoi N, Kanamori M, Horikawa Y, Takeda J, Sanke T, Furuta H, Nanjo K, Mori H, Kasuga M, Hara K, Kadowaki T, Tanizawa Y, Oka Y, Iwami Y, Ohgawara H, Yamada Y, Seino Y, Yano H, Cox NJ, Seino S.

    Diabetes. 2006 Aug;55(8):2379-86.PMID: 16873704 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    The Walter B. Cannon Physiology in Perspective Lecture, 2007. ATP-sensitive K+ channels and disease: from molecule to malady.

    Ashcroft FM.

    Am J Physiol Endocrinol Metab. 2007 Oct;293(4):E880-9. Epub 2007 Jul 24.PMID: 17652156 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes.

    de Wet H, Rees MG, Shimomura K, Aittoniemi J, Patch AM, Flanagan SE, Ellard S, Hattersley AT, Sansom MS, Ashcroft FM.

    Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18988-92. Epub 2007 Nov 19.PMID: 18025464 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP.

    Proks P, Girard C, Ashcroft FM.

    Hum Mol Genet. 2005 Sep 15;14(18):2717-26. Epub 2005 Aug 8.PMID: 16087682 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Physiological and pathophysiological roles of ATP-sensitive K+ channels.

    Seino S, Miki T.

    Prog Biophys Mol Biol. 2003 Feb;81(2):133-76.PMID: 12565699 [PubMed - indexed for MEDLINE]Related articles

    19.

    The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.

    Nielsen EM, Hansen L, Carstensen B, Echwald SM, Drivsholm T, Glümer C, Thorsteinsson B, Borch-Johnsen K, Hansen T, Pedersen O.

    Diabetes. 2003 Feb;52(2):573-7.PMID: 12540638 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action.

    Barroso I, Luan J, Middelberg RP, Harding AH, Franks PW, Jakes RW, Clayton D, Schafer AJ, O'Rahilly S, Wareham NJ.

    PLoS Biol. 2003 Oct;1(1):E20. Epub 2003 Oct 13. Erratum in: PLoS Biol. 2003 Dec;1(3):445. PMID: 14551916 [PubMed - indexed for MEDLINE]Related articlesFree article

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