PubMed

Decreased glibenclamide uptake in hepatocytes of hepatocyte nuclear factor-1alpha-deficient mice: a mechanism for hypersensitivity to sulfonylurea therapy in patients with maturity-onset diabetes of the young, type 3 (MODY3).

Boileau P, Wolfrum C, Shih DQ, Yang TA, Wolkoff AW, Stoffel M.

Diabetes. 2002 Dec;51 Suppl 3:S343-8.PMID: 12475773 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels.

Richter S, Shih DQ, Pearson ER, Wolfrum C, Fajans SS, Hattersley AT, Stoffel M.

Diabetes. 2003 Dec;52(12):2989-95.PMID: 14633861 [PubMed - indexed for MEDLINE]Related articlesFree article

Sensitivity to sulphonylureas in patients with hepatocyte nuclear factor-1alpha gene mutations: evidence for pharmacogenetics in diabetes.

Pearson ER, Liddell WG, Shepherd M, Corrall RJ, Hattersley AT.

Diabet Med. 2000 Jul;17(7):543-5.PMID: 10972586 [PubMed - indexed for MEDLINE]Related articles

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.

Pontoglio M, Sreenan S, Roe M, Pugh W, Ostrega D, Doyen A, Pick AJ, Baldwin A, Velho G, Froguel P, Levisetti M, Bonner-Weir S, Bell GI, Yaniv M, Polonsky KS.

J Clin Invest. 1998 May 15;101(10):2215-22.PMID: 9593777 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells.

Yang Q, Yamagata K, Fukui K, Cao Y, Nammo T, Iwahashi H, Wang H, Matsumura I, Hanafusa T, Bucala R, Wollheim CB, Miyagawa J, Matsuzawa Y.

Diabetes. 2002 Jun;51(6):1785-92.PMID: 12031966 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism.

Shih DQ, Screenan S, Munoz KN, Philipson L, Pontoglio M, Yaniv M, Polonsky KS, Stoffel M.

Diabetes. 2001 Nov;50(11):2472-80.PMID: 11679424 [PubMed - indexed for MEDLINE]Related articlesFree article

Counterregulatory responses to hypoglycemia in patients with maturity-onset diabetes of the young caused by HNF-1alpha gene mutations (MODY3).

Guenat E, Seematter G, Philippe J, Temler E, Jéquier E, Tappy L.

Eur J Endocrinol. 2001 Jan;144(1):45-9.PMID: 11174836 [PubMed - indexed for MEDLINE]Related articlesFree article

Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1alpha mutation carriers.

Sagen JV, Pearson ER, Johansen A, Spyer G, Søvik O, Pedersen O, Njølstad PR, Hattersley AT, Hansen T.

Diabet Med. 2005 Apr;22(4):406-9.PMID: 15787664 [PubMed - indexed for MEDLINE]Related articles

Glucose utilization and production in patients with maturity-onset diabetes of the young caused by a mutation of the hepatocyte nuclear factor-1alpha gene.

Surmely JF, Guenat E, Philippe J, Dussoix P, Schneiter P, Temler E, Vaxillaire M, Froguel P, Jéquier E, Tappy L.

Diabetes. 1998 Sep;47(9):1459-63.PMID: 9726235 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver-specific reactivation of the inactivated Hnf-1alpha gene: elimination of liver dysfunction to establish a mouse MODY3 model.

Lee YH, Magnuson MA, Muppala V, Chen SS.

Mol Cell Biol. 2003 Feb;23(3):923-32.PMID: 12529398 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations.

Pearson ER, Velho G, Clark P, Stride A, Shepherd M, Frayling TM, Bulman MP, Ellard S, Froguel P, Hattersley AT.

Diabetes. 2001 Feb;50 Suppl 1:S101-7.PMID: 11272165 [PubMed - indexed for MEDLINE]Related articles

Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation.

Hansen T, Eiberg H, Rouard M, Vaxillaire M, Møller AM, Rasmussen SK, Fridberg M, Urhammer SA, Holst JJ, Almind K, Echwald SM, Hansen L, Bell GI, Pedersen O.

Diabetes. 1997 Apr;46(4):726-30.PMID: 9075819 [PubMed - indexed for MEDLINE]Related articles

Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta.

Okita K, Yang Q, Yamagata K, Hangenfeldt KA, Miyagawa J, Kajimoto Y, Nakajima H, Namba M, Wollheim CB, Hanafusa T, Matsuzawa Y.

Biochem Biophys Res Commun. 1999 Sep 24;263(2):566-9.PMID: 10491332 [PubMed - indexed for MEDLINE]Related articles

Genetic cause of hyperglycaemia and response to treatment in diabetes.

Pearson ER, Starkey BJ, Powell RJ, Gribble FM, Clark PM, Hattersley AT.

Lancet. 2003 Oct 18;362(9392):1275-81.PMID: 14575972 [PubMed - indexed for MEDLINE]Related articles

Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutations.

Pearson ER, Badman MK, Lockwood CR, Clark PM, Ellard S, Bingham C, Hattersley AT.

Diabetes Care. 2004 May;27(5):1102-7.PMID: 15111528 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic and clinical characterisation of maturity-onset diabetes of the young in Spanish families.

Costa A, Bescós M, Velho G, Chêvre J, Vidal J, Sesmilo G, Bellanné-Chantelot C, Froguel P, Casamitjana R, Rivera-Fillat F, Gomis R, Conget I.

Eur J Endocrinol. 2000 Apr;142(4):380-6.PMID: 10754480 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretion and insulin sensitivity in diabetic and non-diabetic subjects with hepatic nuclear factor-1alpha (maturity-onset diabetes of the young-3) mutations.

Vaxillaire M, Pueyo ME, Clément K, Fiet J, Timsit J, Philippe J, Robert JJ, Tappy L, Froguel P, Velho G.

Eur J Endocrinol. 1999 Dec;141(6):609-18.PMID: 10601964 [PubMed - indexed for MEDLINE]Related articlesFree article

A low renal threshold for glucose in diabetic patients with a mutation in the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene.

Menzel R, Kaisaki PJ, Rjasanowski I, Heinke P, Kerner W, Menzel S.

Diabet Med. 1998 Oct;15(10):816-20.PMID: 9796880 [PubMed - indexed for MEDLINE]Related articles

HNF-1alpha and endodermal transcription factors cooperatively activate Fabpl: MODY3 mutations abrogate cooperativity.

Divine JK, McCaul SP, Simon TC.

Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G62-72. Epub 2003 Mar 19.PMID: 12646418 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver and kidney function in Japanese patients with maturity-onset diabetes of the young.

Iwasaki N, Ogata M, Tomonaga O, Kuroki H, Kasahara T, Yano N, Iwamoto Y.

Diabetes Care. 1998 Dec;21(12):2144-8.PMID: 9839108 [PubMed - indexed for MEDLINE]Related articlesFree article