PubMed

Glucose-regulated gene expression maintaining the glucose-responsive state of beta-cells.

Schuit F, Flamez D, De Vos A, Pipeleers D.

Diabetes. 2002 Dec;51 Suppl 3:S326-32. Review.PMID: 12475771 [PubMed - indexed for MEDLINE]Related articlesFree article

Critical role for cataplerosis via citrate in glucose-regulated insulin release.

Flamez D, Berger V, Kruhøffer M, Orntoft T, Pipeleers D, Schuit FC.

Diabetes. 2002 Jul;51(7):2018-24.PMID: 12086928 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose concentration and AMP-dependent kinase activation regulate expression of insulin receptor family members in rat islets and INS-1E beta cells.

Raile K, Klammt J, Laue S, Garten A, Blüher M, Kralisch S, Klöting N, Kiess W.

Diabetologia. 2005 Sep;48(9):1798-809. Epub 2005 Jul 29.PMID: 16052330 [PubMed - indexed for MEDLINE]Related articles

Anx7 is required for nutritional control of gene expression in mouse pancreatic islets of Langerhans.

Srivastava M, Eidelman O, Leighton X, Glasman M, Goping G, Pollard HB.

Mol Med. 2002 Dec;8(12):781-97.PMID: 12606813 [PubMed - indexed for MEDLINE]Related articlesFree article

Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept.

Holz GG, Habener JF.

Trends Biochem Sci. 1992 Oct;17(10):388-93. Review.PMID: 1455507 [PubMed - indexed for MEDLINE]Related articles

Physiologic relevance of heterogeneity in the pancreatic beta-cell population.

Pipeleers D, Kiekens R, Ling Z, Wilikens A, Schuit F.

Diabetologia. 1994 Sep;37 Suppl 2:S57-64. Review.PMID: 7821741 [PubMed - indexed for MEDLINE]Related articles

Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic beta-cells.

Ubeda M, Kemp DM, Habener JF.

Endocrinology. 2004 Jun;145(6):3023-31. Epub 2004 Feb 19.PMID: 14976144 [PubMed - indexed for MEDLINE]Related articlesFree article

D-Serine exposure resulted in gene expression changes indicative of activation of fibrogenic pathways and down-regulation of energy metabolism and oxidative stress response.

Soto A, DelRaso NJ, Schlager JJ, Chan VT.

Toxicology. 2008 Jan 14;243(1-2):177-92. Epub 2007 Oct 23.PMID: 18061331 [PubMed - indexed for MEDLINE]Related articles

Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.

Ohsugi M, Cras-Méneur C, Zhou Y, Bernal-Mizrachi E, Johnson JD, Luciani DS, Polonsky KS, Permutt MA.

J Biol Chem. 2005 Feb 11;280(6):4992-5003. Epub 2004 Nov 15.PMID: 15546857 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans.

Hribal ML, Perego L, Lovari S, Andreozzi F, Menghini R, Perego C, Finzi G, Usellini L, Placidi C, Capella C, Guzzi V, Lauro D, Bertuzzi F, Davalli A, Pozza G, Pontiroli A, Federici M, Lauro R, Brunetti A, Folli F, Sesti G.

FASEB J. 2003 Jul;17(10):1340-2. Epub 2003 May 8.PMID: 12738810 [PubMed - indexed for MEDLINE]Related articlesFree article

Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells.

Lingohr MK, Briaud I, Dickson LM, McCuaig JF, Alárcon C, Wicksteed BL, Rhodes CJ.

J Biol Chem. 2006 Jun 9;281(23):15884-92. Epub 2006 Mar 30. Erratum in: J Biol Chem. 2006 Aug 11;281(32):23296. PMID: 16574657 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines.

Lilla V, Webb G, Rickenbach K, Maturana A, Steiner DF, Halban PA, Irminger JC.

Endocrinology. 2003 Apr;144(4):1368-79.PMID: 12639920 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.

Moynihan KA, Grimm AA, Plueger MM, Bernal-Mizrachi E, Ford E, Cras-Méneur C, Permutt MA, Imai S.

Cell Metab. 2005 Aug;2(2):105-17.PMID: 16098828 [PubMed - indexed for MEDLINE]Related articles

Voltage-dependent K(+) channels in pancreatic beta cells: role, regulation and potential as therapeutic targets.

MacDonald PE, Wheeler MB.

Diabetologia. 2003 Aug;46(8):1046-62. Epub 2003 Jun 27. Review.PMID: 12830383 [PubMed - indexed for MEDLINE]Related articles

Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose.

Ritzel RA, Hansen JB, Veldhuis JD, Butler PC.

J Clin Endocrinol Metab. 2004 Feb;89(2):795-805.PMID: 14764798 [PubMed - indexed for MEDLINE]Related articlesFree article

Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels.

Zitzer H, Wente W, Brenner MB, Sewing S, Buschard K, Gromada J, Efanov AM.

Endocrinology. 2006 Aug;147(8):3898-905. Epub 2006 Apr 27.PMID: 16644917 [PubMed - indexed for MEDLINE]Related articlesFree article

ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter.

Lawrence MC, McGlynn K, Park BH, Cobb MH.

J Biol Chem. 2005 Jul 22;280(29):26751-9. Epub 2005 May 16.PMID: 15899886 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1.

Mosley AL, Corbett JA, Ozcan S.

Mol Endocrinol. 2004 Sep;18(9):2279-90. Epub 2004 May 27.PMID: 15166251 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass.

Roccisana J, Reddy V, Vasavada RC, Gonzalez-Pertusa JA, Magnuson MA, Garcia-Ocaña A.

Diabetes. 2005 Jul;54(7):2090-102.PMID: 15983210 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced repression of PPARalpha gene expression in pancreatic beta-cells involves PP2A activation and AMPK inactivation.

Ravnskjaer K, Boergesen M, Dalgaard LT, Mandrup S.

J Mol Endocrinol. 2006 Apr;36(2):289-99.PMID: 16595700 [PubMed - indexed for MEDLINE]Related articlesFree article