PubMed

The prevalence of the HNF-1alpha G319S mutation in Canadian aboriginal youth with type 2 diabetes.

Sellers EA, Triggs-Raine B, Rockman-Greenberg C, Dean HJ.

Diabetes Care. 2002 Dec;25(12):2202-6.PMID: 12453961 [PubMed - indexed for MEDLINE]Related articlesFree article

The hepatic nuclear factor-1alpha G319S variant is associated with early-onset type 2 diabetes in Canadian Oji-Cree.

Hegele RA, Cao H, Harris SB, Hanley AJ, Zinman B.

J Clin Endocrinol Metab. 1999 Mar;84(3):1077-82.PMID: 10084598 [PubMed - indexed for MEDLINE]Related articlesFree article

HNF-1alpha G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community.

Triggs-Raine BL, Kirkpatrick RD, Kelly SL, Norquay LD, Cattini PA, Yamagata K, Hanley AJ, Zinman B, Harris SB, Barrett PH, Hegele RA.

Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4614-9. Epub 2002 Mar 19.PMID: 11904371 [PubMed - indexed for MEDLINE]Related articlesFree article

High frequency of mutations in the HNF-1alpha gene in non-obese patients with diabetes of youth in Japanese and identification of a case of digenic inheritance.

Tonooka N, Tomura H, Takahashi Y, Onigata K, Kikuchi N, Horikawa Y, Mori M, Takeda J.

Diabetologia. 2002 Dec;45(12):1709-12. Epub 2002 Nov 16.PMID: 12488961 [PubMed - indexed for MEDLINE]Related articles

The private hepatocyte nuclear factor-1alpha G319S variant is associated with plasma lipoprotein variation in Canadian Oji-Cree.

Hegele RA, Cao H, Harris SB, Hanley AJ, Zinman B, Connelly PW.

Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):217-22.PMID: 10634821 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification and functional characterization of a novel mutation of hepatocyte nuclear factor-1alpha gene in a Korean family with MODY3.

Kim KA, Kang K, Chi YI, Chang I, Lee MK, Kim KW, Shoelson SE, Lee MS.

Diabetologia. 2003 May;46(5):721-7. Epub 2003 Apr 24.PMID: 12712243 [PubMed - indexed for MEDLINE]Related articles

Mutations in the hepatocyte nuclear factor-1alpha gene in Caucasian families originally classified as having Type I diabetes.

Møller AM, Dalgaard LT, Pociot F, Nerup J, Hansen T, Pedersen O.

Diabetologia. 1998 Dec;41(12):1528-31.PMID: 9867222 [PubMed - indexed for MEDLINE]Related articles

Variants in the hepatocyte nuclear factor-1alpha and -4alpha genes in Finnish and Chinese subjects with late-onset type 2 diabetes.

Rissanen J, Wang H, Miettinen R, Kärkkäinen P, Kekäläinen P, Mykkänen L, Kuusisto J, Karhapää P, Niskanen L, Uusitupa M, Laakso M.

Diabetes Care. 2000 Oct;23(10):1533-8.PMID: 11023148 [PubMed - indexed for MEDLINE]Related articlesFree article

Identifying hepatic nuclear factor 1alpha mutations in children and young adults with a clinical diagnosis of type 1 diabetes.

Lambert AP, Ellard S, Allen LI, Gallen IW, Gillespie KM, Bingley PJ, Hattersley AT.

Diabetes Care. 2003 Feb;26(2):333-7.PMID: 12547858 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevalence of the missense mutation Gly574Ser in the hepatocyte nuclear factor-1alpha in Africans with diabetes.

Collet C, Ducorps M, Mayaudon H, Dupuy O, Ceppa F, Boutin P, Froguel P, Bauduceau B.

Diabetes Metab. 2002 Feb;28(1):39-44.PMID: 11938027 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset type 2 diabetes mellitus/MODY.

Ng MC, Cockburn BN, Lindner TH, Yeung VT, Chow CC, So WY, Li JK, Lo YM, Lee ZS, Cockram CS, Critchley JA, Bell GI, Chan JC.

Diabet Med. 1999 Nov;16(11):956-63.PMID: 10588527 [PubMed - indexed for MEDLINE]Related articles

beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.

Frayling TM, Evans JC, Bulman MP, Pearson E, Allen L, Owen K, Bingham C, Hannemann M, Shepherd M, Ellard S, Hattersley AT.

Diabetes. 2001 Feb;50 Suppl 1:S94-100.PMID: 11272211 [PubMed - indexed for MEDLINE]Related articles

Familial early-onset type 2 diabetes in Chinese patients: obesity and genetics have more significant roles than autoimmunity.

Ng MC, Lee SC, Ko GT, Li JK, So WY, Hashim Y, Barnett AH, Mackay IR, Critchley JA, Cockram CS, Chan JC.

Diabetes Care. 2001 Apr;24(4):663-71.PMID: 11315828 [PubMed - indexed for MEDLINE]Related articlesFree article

Gender, obesity, hepatic nuclear factor-1alpha G319S and the age-of-onset of type 2 diabetes in Canadian Oji-Cree.

Hegele RA, Cao H, Harris SB, Zinman B, Hanley AJ, Anderson CM.

Int J Obes Relat Metab Disord. 2000 Aug;24(8):1062-4.PMID: 10951547 [PubMed - indexed for MEDLINE]Related articles

beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations.

Pearson ER, Velho G, Clark P, Stride A, Shepherd M, Frayling TM, Bulman MP, Ellard S, Froguel P, Hattersley AT.

Diabetes. 2001 Feb;50 Suppl 1:S101-7.PMID: 11272165 [PubMed - indexed for MEDLINE]Related articles

Three new mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with diabetes mellitus: clinical features and functional characterization.

Yoshiuchi I, Yamagata K, Yang Q, Iwahashi H, Okita K, Yamamoto K, Oue T, Imagawa A, Hamaguchi T, Yamasaki T, Horikawa Y, Satoh T, Nakajima H, Miyazaki J, Higashiyama S, Miyagawa J, Namba M, Hanafusa T, Matsuzawa Y.

Diabetologia. 1999 May;42(5):621-6.PMID: 10333057 [PubMed - indexed for MEDLINE]Related articles

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.

Pontoglio M, Sreenan S, Roe M, Pugh W, Ostrega D, Doyen A, Pick AJ, Baldwin A, Velho G, Froguel P, Levisetti M, Bonner-Weir S, Bell GI, Yaniv M, Polonsky KS.

J Clin Invest. 1998 May 15;101(10):2215-22.PMID: 9593777 [PubMed - indexed for MEDLINE]Related articlesFree article

Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutations.

Pearson ER, Badman MK, Lockwood CR, Clark PM, Ellard S, Bingham C, Hattersley AT.

Diabetes Care. 2004 May;27(5):1102-7.PMID: 15111528 [PubMed - indexed for MEDLINE]Related articlesFree article

Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta.

Okita K, Yang Q, Yamagata K, Hangenfeldt KA, Miyagawa J, Kajimoto Y, Nakajima H, Namba M, Wollheim CB, Hanafusa T, Matsuzawa Y.

Biochem Biophys Res Commun. 1999 Sep 24;263(2):566-9.PMID: 10491332 [PubMed - indexed for MEDLINE]Related articles

Beta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers.

Stride A, Ellard S, Clark P, Shakespeare L, Salzmann M, Shepherd M, Hattersley AT.

Diabetes Care. 2005 Jul;28(7):1751-6.PMID: 15983330 [PubMed - indexed for MEDLINE]Related articlesFree article