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    Results: 1 to 20 of 125

    1.

    Interleukin-6 induces cellular insulin resistance in hepatocytes.

    Senn JJ, Klover PJ, Nowak IA, Mooney RA.

    Diabetes. 2002 Dec;51(12):3391-9.PMID: 12453891 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes.

    Senn JJ, Klover PJ, Nowak IA, Zimmers TA, Koniaris LG, Furlanetto RW, Mooney RA.

    J Biol Chem. 2003 Apr 18;278(16):13740-6. Epub 2003 Jan 30.PMID: 12560330 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes.

    He J, Usui I, Ishizuka K, Kanatani Y, Hiratani K, Iwata M, Bukhari A, Haruta T, Sasaoka T, Kobayashi M.

    Mol Endocrinol. 2006 Jan;20(1):114-24. Epub 2005 Sep 8.PMID: 16150868 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes.

    Henkel J, Neuschäfer-Rube F, Pathe-Neuschäfer-Rube A, Püschel GP.

    Hepatology. 2009 Sep;50(3):781-90.PMID: 19575453 [PubMed - indexed for MEDLINE]Related articles

    5.

    Prolonged treatment of primary hepatocytes with oleate induces insulin resistance through p38 mitogen-activated protein kinase.

    Liu HY, Collins QF, Xiong Y, Moukdar F, Lupo EG Jr, Liu Z, Cao W.

    J Biol Chem. 2007 May 11;282(19):14205-12. Epub 2007 Mar 25.PMID: 17384440 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB.

    Weigert C, Brodbeck K, Staiger H, Kausch C, Machicao F, Häring HU, Schleicher ED.

    J Biol Chem. 2004 Jun 4;279(23):23942-52. Epub 2004 Mar 17.PMID: 15028733 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.

    Gonzalez-Rodriguez A, Clampit JE, Escribano O, Benito M, Rondinone CM, Valverde AM.

    Endocrinology. 2007 Feb;148(2):594-608. Epub 2006 Oct 26.PMID: 17068137 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes.

    Valverde AM, Fabregat I, Burks DJ, White MF, Benito M.

    Hepatology. 2004 Dec;40(6):1285-94.PMID: 15565601 [PubMed - indexed for MEDLINE]Related articles

    9.

    Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus.

    Hartman ME, O'Connor JC, Godbout JP, Minor KD, Mazzocco VR, Freund GG.

    J Biol Chem. 2004 Jul 2;279(27):28045-50. Epub 2004 Apr 27.PMID: 15123681 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression.

    Jager J, Grémeaux T, Cormont M, Le Marchand-Brustel Y, Tanti JF.

    Endocrinology. 2007 Jan;148(1):241-51. Epub 2006 Oct 12.PMID: 17038556 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Fes mediates the IL-4 activation of insulin receptor substrate-2 and cellular proliferation.

    Jiang H, Foltenyi K, Kashiwada M, Donahue L, Vuong B, Hehn B, Rothman P.

    J Immunol. 2001 Feb 15;166(4):2627-34.PMID: 11160325 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Morphine induces desensitization of insulin receptor signaling.

    Li Y, Eitan S, Wu J, Evans CJ, Kieffer B, Sun X, Polakiewicz RD.

    Mol Cell Biol. 2003 Sep;23(17):6255-66.PMID: 12917346 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells.

    Andreozzi F, Laratta E, Procopio C, Hribal ML, Sciacqua A, Perticone M, Miele C, Perticone F, Sesti G.

    Mol Cell Biol. 2007 Mar;27(6):2372-83. Epub 2007 Jan 22.PMID: 17242212 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Tumor necrosis factor-alpha induces insulin resistance in endothelial cells via a p38 mitogen-activated protein kinase-dependent pathway.

    Li G, Barrett EJ, Barrett MO, Cao W, Liu Z.

    Endocrinology. 2007 Jul;148(7):3356-63. Epub 2007 Apr 19.PMID: 17446186 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.

    Andreozzi F, D'Alessandris C, Federici M, Laratta E, Del Guerra S, Del Prato S, Marchetti P, Lauro R, Perticone F, Sesti G.

    Endocrinology. 2004 Jun;145(6):2845-57. Epub 2004 Mar 4.PMID: 15001544 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.

    Wick KR, Werner ED, Langlais P, Ramos FJ, Dong LQ, Shoelson SE, Liu F.

    J Biol Chem. 2003 Mar 7;278(10):8460-7. Epub 2002 Dec 18.PMID: 12493740 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance.

    Kim JA, Yeh DC, Ver M, Li Y, Carranza A, Conrads TP, Veenstra TD, Harrington MA, Quon MJ.

    J Biol Chem. 2005 Jun 17;280(24):23173-83. Epub 2005 Apr 22.PMID: 15849359 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Receptor-type protein tyrosine phosphatase epsilon (PTPepsilonM) is a negative regulator of insulin signaling in primary hepatocytes and liver.

    Nakagawa Y, Aoki N, Aoyama K, Shimizu H, Shimano H, Yamada N, Miyazaki H.

    Zoolog Sci. 2005 Feb;22(2):169-75.PMID: 15738637 [PubMed - indexed for MEDLINE]Related articles

    19.

    Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism.

    Miele C, Riboulet A, Maitan MA, Oriente F, Romano C, Formisano P, Giudicelli J, Beguinot F, Van Obberghen E.

    J Biol Chem. 2003 Nov 28;278(48):47376-87. Epub 2003 Sep 11.PMID: 12970360 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation.

    Mur C, Arribas M, Benito M, Valverde AM.

    Endocrinology. 2003 Feb;144(2):581-93.PMID: 12538620 [PubMed - indexed for MEDLINE]Related articlesFree article

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