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The role of structural genes in the pathogenesis of osteoarthritic disorders.

Reginato AM, Olsen BR.

Arthritis Res. 2002;4(6):337-45. Epub 2002 Aug 30. Review.PMID: 12453309 [PubMed - indexed for MEDLINE]Related articlesFree article

The contribution of genes to osteoarthritis.

Valdes AM, Spector TD.

Rheum Dis Clin North Am. 2008 Aug;34(3):581-603.PMID: 18687274 [PubMed - indexed for MEDLINE]Related articles

Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis.

Xu L, Peng H, Glasson S, Lee PL, Hu K, Ijiri K, Olsen BR, Goldring MB, Li Y.

Arthritis Rheum. 2007 Aug;56(8):2663-73.PMID: 17665456 [PubMed - indexed for MEDLINE]Related articlesFree article

Osteoarthritis.

Goldring MB, Goldring SR.

J Cell Physiol. 2007 Dec;213(3):626-34. Review.PMID: 17786965 [PubMed - indexed for MEDLINE]Related articles

Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes.

Ijiri K, Zerbini LF, Peng H, Otu HH, Tsuchimochi K, Otero M, Dragomir C, Walsh N, Bierbaum BE, Mattingly D, van Flandern G, Komiya S, Aigner T, Libermann TA, Goldring MB.

Arthritis Rheum. 2008 Jul;58(7):2075-87.PMID: 18576389 [PubMed - indexed for MEDLINE]Related articlesFree article

The genetic epidemiology of human primary osteoarthritis: current status.

Loughlin J.

Expert Rev Mol Med. 2005 May 24;7(9):1-12. Review.PMID: 15910695 [PubMed - indexed for MEDLINE]Related articles

Chondrocyte cluster formation in agarose cultures as a functional assay to identify genes expressed in osteoarthritis.

Quintavalla J, Kumar C, Daouti S, Slosberg E, Uziel-Fusi S.

J Cell Physiol. 2005 Aug;204(2):560-6.PMID: 15799031 [PubMed - indexed for MEDLINE]Related articles

Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytes.

Wang J, Gardner BM, Lu Q, Rodova M, Woodbury BG, Yost JG, Roby KF, Pinson DM, Tawfik O, Anderson HC.

J Pathol. 2009 Oct;219(2):163-72.PMID: 19526482 [PubMed - indexed for MEDLINE]Related articles

Reference genes for normalization of gene expression studies in human osteoarthritic articular cartilage.

Pombo-Suarez M, Calaza M, Gomez-Reino JJ, Gonzalez A.

BMC Mol Biol. 2008 Jan 29;9:17.PMID: 18226276 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction.

Clements DN, Carter SD, Innes JF, Ollier WE, Day PJ.

Arthritis Res Ther. 2006;8(6):R158.PMID: 17032449 [PubMed - indexed for MEDLINE]Related articlesFree article

BMP receptor signaling is required for postnatal maintenance of articular cartilage.

Rountree RB, Schoor M, Chen H, Marks ME, Harley V, Mishina Y, Kingsley DM.

PLoS Biol. 2004 Nov;2(11):e355. Epub 2004 Oct 19.PMID: 15492776 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism.

Simopoulou T, Malizos KN, Iliopoulos D, Stefanou N, Papatheodorou L, Ioannou M, Tsezou A.

Osteoarthritis Cartilage. 2007 Aug;15(8):872-83. Epub 2007 Mar 9.PMID: 17350295 [PubMed - indexed for MEDLINE]Related articles

Development of comprehensive functional genomic screens to identify novel mediators of osteoarthritis.

Daouti S, Latario B, Nagulapalli S, Buxton F, Uziel-Fusi S, Chirn GW, Bodian D, Song C, Labow M, Lotz M, Quintavalla J, Kumar C.

Osteoarthritis Cartilage. 2005 Jun;13(6):508-18.PMID: 15922185 [PubMed - indexed for MEDLINE]Related articles

Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage.

Gebauer M, Saas J, Haag J, Dietz U, Takigawa M, Bartnik E, Aigner T.

Arthritis Res Ther. 2005;7(2):R274-84. Epub 2005 Jan 11.PMID: 15743474 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular biological approaches to the study of heritable osteoarthritis.

Jimenez SA.

J Rheumatol Suppl. 1991 Feb;27:7-9. Review.PMID: 1674006 [PubMed - indexed for MEDLINE]Related articles

Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks.

Iliopoulos D, Malizos KN, Oikonomou P, Tsezou A.

PLoS One. 2008;3(11):e3740. Epub 2008 Nov 17.PMID: 19011694 [PubMed - indexed for MEDLINE]Related articlesFree article

Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy.

Tchetina EV, Di Battista JA, Zukor DJ, Antoniou J, Poole AR.

Arthritis Res Ther. 2007;9(4):R75.PMID: 17683641 [PubMed - indexed for MEDLINE]Related articlesFree article

Heritable diseases of cartilage caused by mutations in collagen genes.

Williams CJ, Jimenez SA.

J Rheumatol Suppl. 1995 Feb;43:28-33. Review.PMID: 7752129 [PubMed - indexed for MEDLINE]Related articles

Microarray analysis of differential gene expression in temporomandibular joint condylar cartilage after experimentally induced osteoarthritis.

Meng J, Ma X, Ma D, Xu C.

Osteoarthritis Cartilage. 2005 Dec;13(12):1115-25.PMID: 15905105 [PubMed - indexed for MEDLINE]Related articles

Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation.

Cheung KS, Hashimoto K, Yamada N, Roach HI.

Rheumatol Int. 2009 Mar;29(5):525-34. Epub 2008 Oct 22.PMID: 18941754 [PubMed - indexed for MEDLINE]Related articles