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    Results: 1 to 20 of 439

    1.

    Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.

    Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA.

    J Biol. 2002 Nov 6;1(2):10.

    PMID:
    12437772
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    2.

    Sonic hedgehog signaling by the patched-smoothened receptor complex.

    Murone M, Rosenthal A, de Sauvage FJ.

    Curr Biol. 1999 Jan 28;9(2):76-84.

    PMID:
    10021362
    [PubMed - indexed for MEDLINE]
    3.

    Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15.

    Masdeu C, Faure H, Coulombe J, Schoenfelder A, Mann A, Brabet I, Pin JP, Traiffort E, Ruat M.

    Biochem Biophys Res Commun. 2006 Oct 20;349(2):471-9. Epub 2006 Aug 22.

    PMID:
    16945339
    [PubMed - indexed for MEDLINE]
    4.

    Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis.

    Jaskoll T, Leo T, Witcher D, Ormestad M, Astorga J, Bringas P Jr, Carlsson P, Melnick M.

    Dev Dyn. 2004 Apr;229(4):722-32.

    PMID:
    15042696
    [PubMed - indexed for MEDLINE]
    Free Article
    5.

    A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord.

    Wijgerde M, McMahon JA, Rule M, McMahon AP.

    Genes Dev. 2002 Nov 15;16(22):2849-64.

    PMID:
    12435628
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    6.

    Patched acts catalytically to suppress the activity of Smoothened.

    Taipale J, Cooper MK, Maiti T, Beachy PA.

    Nature. 2002 Aug 22;418(6900):892-7. Erratum in: Nature 2002 Nov 28;420(6914):445.

    PMID:
    12192414
    [PubMed - indexed for MEDLINE]
    7.

    Evidence for allosteric interactions of antagonist binding to the smoothened receptor.

    Rominger CM, Bee WL, Copeland RA, Davenport EA, Gilmartin A, Gontarek R, Hornberger KR, Kallal LA, Lai Z, Lawrie K, Lu Q, McMillan L, Truong M, Tummino PJ, Turunen B, Will M, Zuercher WJ, Rominger DH.

    J Pharmacol Exp Ther. 2009 Jun;329(3):995-1005. Epub 2009 Mar 20. Erratum in: J Pharmacol Exp Ther. 2010 Feb;332(2):690.

    PMID:
    19304771
    [PubMed - indexed for MEDLINE]
    Free Article
    8.

    Small molecule modulation of Smoothened activity.

    Chen JK, Taipale J, Young KE, Maiti T, Beachy PA.

    Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6. Epub 2002 Oct 21.

    PMID:
    12391318
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    9.

    Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.

    Reiter JF, Skarnes WC.

    Genes Dev. 2006 Jan 1;20(1):22-7. Epub 2005 Dec 15.

    PMID:
    16357211
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    10.

    Regulation of Hedgehog signaling: a complex story.

    Ogden SK, Ascano M Jr, Stegman MA, Robbins DJ.

    Biochem Pharmacol. 2004 Mar 1;67(5):805-14. Review.

    PMID:
    15104233
    [PubMed - indexed for MEDLINE]
    11.

    Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.

    Svärd J, Heby-Henricson K, Persson-Lek M, Rozell B, Lauth M, Bergström A, Ericson J, Toftgård R, Teglund S.

    Dev Cell. 2006 Feb;10(2):187-97. Erratum in: Dev Cell. 2006 Mar;10(3):409. Henricson, Karin Heby [corrected to Heby-Henricson, Karin].

    PMID:
    16459298
    [PubMed - indexed for MEDLINE]
    12.

    Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist.

    Roudaut H, Traiffort E, Gorojankina T, Vincent L, Faure H, Schoenfelder A, Mann A, Manetti F, Solinas A, Taddei M, Ruat M.

    Mol Pharmacol. 2011 Mar;79(3):453-60. Epub 2010 Dec 21.

    PMID:
    21177415
    [PubMed - indexed for MEDLINE]
    13.

    Small-molecule modulators of the Sonic Hedgehog signaling pathway.

    Stanton BZ, Peng LF.

    Mol Biosyst. 2010 Jan;6(1):44-54. Epub 2009 Aug 27. Review.

    PMID:
    20024066
    [PubMed - indexed for MEDLINE]
    14.

    G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.

    Ogden SK, Fei DL, Schilling NS, Ahmed YF, Hwa J, Robbins DJ.

    Nature. 2008 Dec 18;456(7224):967-70.

    PMID:
    18987629
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    15.

    Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein.

    Ingham PW, Nystedt S, Nakano Y, Brown W, Stark D, van den Heuvel M, Taylor AM.

    Curr Biol. 2000 Oct 19;10(20):1315-8.

    PMID:
    11069117
    [PubMed - indexed for MEDLINE]
    16.

    Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis.

    Sicklick JK, Li YX, Jayaraman A, Kannangai R, Qi Y, Vivekanandan P, Ludlow JW, Owzar K, Chen W, Torbenson MS, Diehl AM.

    Carcinogenesis. 2006 Apr;27(4):748-57. Epub 2005 Dec 8.

    PMID:
    16339184
    [PubMed - indexed for MEDLINE]
    Free Article
    17.

    Targeting the hedgehog signaling pathway with small molecules.

    Kiselyov AS.

    Anticancer Agents Med Chem. 2006 Sep;6(5):445-9. Review.

    PMID:
    17017853
    [PubMed - indexed for MEDLINE]
    18.

    Intrastriatal sonic hedgehog injection increases Patched transcript levels in the adult rat subventricular zone.

    Charytoniuk D, Traiffort E, Hantraye P, Hermel JM, Galdes A, Ruat M.

    Eur J Neurosci. 2002 Dec;16(12):2351-7.

    PMID:
    12492430
    [PubMed - indexed for MEDLINE]
    19.

    Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells.

    van der Horst G, Farih-Sips H, Löwik CW, Karperien M.

    Bone. 2003 Dec;33(6):899-910.

    PMID:
    14678849
    [PubMed - indexed for MEDLINE]

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