PubMed

Roughing up Smoothened: chemical modulators of hedgehog signaling.

King RW.

J Biol. 2002 Nov 6;1(2):8. Review.PMID: 12437769 [PubMed - indexed for MEDLINE]Related articlesFree article

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.

Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA.

J Biol. 2002 Nov 6;1(2):10.PMID: 12437772 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.

Chen JK, Taipale J, Cooper MK, Beachy PA.

Genes Dev. 2002 Nov 1;16(21):2743-8.PMID: 12414725 [PubMed - indexed for MEDLINE]Related articlesFree article

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

Sinha S, Chen JK.

Nat Chem Biol. 2006 Jan;2(1):29-30. Epub 2005 Nov 20.PMID: 16408088 [PubMed - indexed for MEDLINE]Related articles

Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis.

Jaskoll T, Leo T, Witcher D, Ormestad M, Astorga J, Bringas P Jr, Carlsson P, Melnick M.

Dev Dyn. 2004 Apr;229(4):722-32.PMID: 15042696 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.

Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA.

Nature. 2000 Aug 31;406(6799):1005-9.PMID: 10984056 [PubMed - indexed for MEDLINE]Related articles

Erythroid differentiation in vitro is blocked by cyclopamine, an inhibitor of hedgehog signaling.

Detmer K, Walker AN, Jenkins TM, Steele TA, Dannawi H.

Blood Cells Mol Dis. 2000 Aug;26(4):360-72.PMID: 11042037 [PubMed - indexed for MEDLINE]Related articles

Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells.

Dwyer JR, Sever N, Carlson M, Nelson SF, Beachy PA, Parhami F.

J Biol Chem. 2007 Mar 23;282(12):8959-68. Epub 2007 Jan 2.PMID: 17200122 [PubMed - indexed for MEDLINE]Related articlesFree article

Cancer: a twist in a hedgehog's tale.

Scott MP.

Nature. 2003 Oct 23;425(6960):780-2. No abstract available. PMID: 14574396 [PubMed - indexed for MEDLINE]Related articles

Targeting the hedgehog signaling pathway with small molecules.

Kiselyov AS.

Anticancer Agents Med Chem. 2006 Sep;6(5):445-9. Review.PMID: 17017853 [PubMed - indexed for MEDLINE]Related articles

Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells.

van der Horst G, Farih-Sips H, Löwik CW, Karperien M.

Bone. 2003 Dec;33(6):899-910.PMID: 14678849 [PubMed - indexed for MEDLINE]Related articles

Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo).

Zhang X, Harrington N, Moraes RC, Wu MF, Hilsenbeck SG, Lewis MT.

Breast Cancer Res Treat. 2009 Jun;115(3):505-21. Epub 2008 Jun 19.PMID: 18563554 [PubMed - indexed for MEDLINE]Related articles

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation.

Wang Y, Zhou Z, Walsh CT, McMahon AP.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2623-8. Epub 2009 Feb 5.PMID: 19196978 [PubMed - indexed for MEDLINE]Related articlesFree article

Sonic hedgehog promotes porcine oocyte maturation and early embryo development.

Nguyen NT, Lin DP, Yen SY, Tseng JK, Chuang JF, Chen BY, Lin TA, Chang HH, Ju JC.

Reprod Fertil Dev. 2009;21(6):805-15.PMID: 19567223 [PubMed - indexed for MEDLINE]Related articles

Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity.

Tabs S, Avci O.

Eur J Dermatol. 2004 Mar-Apr;14(2):96-102.PMID: 15196999 [PubMed - indexed for MEDLINE]Related articlesFree article

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.

Meloni AR, Fralish GB, Kelly P, Salahpour A, Chen JK, Wechsler-Reya RJ, Lefkowitz RJ, Caron MG.

Mol Cell Biol. 2006 Oct;26(20):7550-60. Epub 2006 Aug 14.PMID: 16908539 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport.

Incardona JP, Gaffield W, Lange Y, Cooney A, Pentchev PG, Liu S, Watson JA, Kapur RP, Roelink H.

Dev Biol. 2000 Aug 15;224(2):440-52.PMID: 10926779 [PubMed - indexed for MEDLINE]Related articles

Inhibition of the anti-adipogenic Hedgehog signaling pathway by cyclopamine does not trigger adipocyte differentiation.

Cousin W, Dani C, Peraldi P.

Biochem Biophys Res Commun. 2006 Oct 20;349(2):799-803. Epub 2006 Aug 28.PMID: 16949046 [PubMed - indexed for MEDLINE]Related articles

Recruitment of the Sonic hedgehog signalling cascade in electroconvulsive seizure-mediated regulation of adult rat hippocampal neurogenesis.

Banerjee SB, Rajendran R, Dias BG, Ladiwala U, Tole S, Vaidya VA.

Eur J Neurosci. 2005 Oct;22(7):1570-80.PMID: 16197497 [PubMed - indexed for MEDLINE]Related articles

Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis.

Athar M, Li C, Tang X, Chi S, Zhang X, Kim AL, Tyring SK, Kopelovich L, Hebert J, Epstein EH Jr, Bickers DR, Xie J.

Cancer Res. 2004 Oct 15;64(20):7545-52.PMID: 15492281 [PubMed - indexed for MEDLINE]Related articlesFree article