Warning: The NCBI web site requires JavaScript to function. more...
The presenilins.
Tandon A, Fraser P.
Genome Biol. 2002 Oct 23;3(11):reviews3014. Epub 2002 Oct 23. Review.
Related citations
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ.
Nature. 1999 Apr 8;398(6727):513-7.
gamma-Secretase inhibitors as molecular probes of presenilin function.
Wolfe MS.
J Mol Neurosci. 2001 Oct;17(2):199-204. Review.
Secretase as a target for Alzheimer's disease.
Curr Top Med Chem. 2002 Apr;2(4):371-83. Review.
Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
Li T, Ma G, Cai H, Price DL, Wong PC.
J Neurosci. 2003 Apr 15;23(8):3272-7.
Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins.
Cervantes S, Saura CA, Pomares E, Gonzàlez-Duarte R, Marfany G.
J Biol Chem. 2004 Aug 27;279(35):36519-29. Epub 2004 Jun 25.
Presenilins as therapeutic targets for the treatment of Alzheimer's disease.
Golde TE, Younkin SG.
Trends Mol Med. 2001 Jun;7(6):264-9. Review.
Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.
J Neurochem. 2005 Sep;94(5):1189-201. Epub 2005 Jun 30.
The presenilins in Alzheimer's disease--proteolysis holds the key.
Haass C, De Strooper B.
Science. 1999 Oct 29;286(5441):916-9. Review.
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D.
Dev Cell. 2002 Jul;3(1):85-97.
Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.
Evin G, Sharples RA, Weidemann A, Reinhard FB, Carbone V, Culvenor JG, Holsinger RM, Sernee MF, Beyreuther K, Masters CL.
Biochemistry. 2001 Jul 27;40(28):8359-68.
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.
Wolfe MS, De Los Angeles J, Miller DD, Xia W, Selkoe DJ.
Biochemistry. 1999 Aug 31;38(35):11223-30. Review.
The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins.
Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R, De Strooper B, Iwatsubo T.
J Biol Chem. 2001 Aug 31;276(35):33273-81. Epub 2001 Jun 29.
Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.
Li G, Percontino L, Sun Q, Qazi AS, Frederikse PH.
Mol Vis. 2003 May 1;9:179-83.
A portrait of Alzheimer secretases--new features and familiar faces.
Esler WP, Wolfe MS.
Science. 2001 Aug 24;293(5534):1449-54. Review.
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS.
Nat Cell Biol. 2000 Jul;2(7):428-34.
Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.
Alves da Costa C, Sunyach C, Pardossi-Piquard R, Sévalle J, Vincent B, Boyer N, Kawarai T, Girardot N, St George-Hyslop P, Checler F.
J Neurosci. 2006 Jun 7;26(23):6377-85.
Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.
J Neurochem. 2006 Feb;96(3):732-42. Epub 2006 Jan 9.
Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, Selkoe DJ, Wolfe MS.
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2720-5. Epub 2002 Feb 26.
Intramembrane proteolysis by presenilins.
Steiner H, Haass C.
Nat Rev Mol Cell Biol. 2000 Dec;1(3):217-24. Review.
Filter your results:
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on