PubMed

Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. A randomized, double-blind, placebo-controlled trial.

Kremer JM, Genovese MC, Cannon GW, Caldwell JR, Cush JJ, Furst DE, Luggen ME, Keystone E, Weisman MH, Bensen WM, Kaine JL, Ruderman EM, Coleman P, Curtis DL, Kopp EJ, Kantor SM, Waltuck J, Lindsley HB, Markenson JA, Strand V, Crawford B, Fernando I, Simpson K, Bathon JM.

Ann Intern Med. 2002 Nov 5;137(9):726-33.PMID: 12416946 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group.

Strand V, Cohen S, Schiff M, Weaver A, Fleischmann R, Cannon G, Fox R, Moreland L, Olsen N, Furst D, Caldwell J, Kaine J, Sharp J, Hurley F, Loew-Friedrich I.

Arch Intern Med. 1999 Nov 22;159(21):2542-50.PMID: 10573044 [PubMed - indexed for MEDLINE]Related articlesFree article

Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Utilization of Leflunomide in the Treatment of Rheumatoid Arthritis Trial Investigator Group.

Cohen S, Cannon GW, Schiff M, Weaver A, Fox R, Olsen N, Furst D, Sharp J, Moreland L, Caldwell J, Kaine J, Strand V.

Arthritis Rheum. 2001 Sep;44(9):1984-92.PMID: 11592358 [PubMed - indexed for MEDLINE]Related articlesFree article

Function and health-related quality of life: results from a randomized controlled trial of leflunomide versus methotrexate or placebo in patients with active rheumatoid arthritis. Leflunomide Rheumatoid Arthritis Investigators Group.

Strand V, Tugwell P, Bombardier C, Maetzel A, Crawford B, Dorrier C, Thompson A, Wells G.

Arthritis Rheum. 1999 Sep;42(9):1870-8.PMID: 10513801 [PubMed - indexed for MEDLINE]Related articlesFree article

Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-week trial.

Keystone EC, Kavanaugh AF, Sharp JT, Tannenbaum H, Hua Y, Teoh LS, Fischkoff SA, Chartash EK.

Arthritis Rheum. 2004 May;50(5):1400-11.PMID: 15146409 [PubMed - indexed for MEDLINE]Related articlesFree article

Leflunomide in the treatment of rheumatoid arthritis.

Li EK, Tam LS, Tomlinson B.

Clin Ther. 2004 Apr;26(4):447-59. Review.PMID: 15189743 [PubMed - indexed for MEDLINE]Related articles

Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial.

Cohen S, Hurd E, Cush J, Schiff M, Weinblatt ME, Moreland LW, Kremer J, Bear MB, Rich WJ, McCabe D.

Arthritis Rheum. 2002 Mar;46(3):614-24.PMID: 11920396 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficacy, pharmacokinetic, and safety assessment of adalimumab, a fully human anti-tumor necrosis factor-alpha monoclonal antibody, in adults with rheumatoid arthritis receiving concomitant methotrexate: a pilot study.

Weisman MH, Moreland LW, Furst DE, Weinblatt ME, Keystone EC, Paulus HE, Teoh LS, Velagapudi RB, Noertersheuser PA, Granneman GR, Fischkoff SA, Chartash EK.

Clin Ther. 2003 Jun;25(6):1700-21.PMID: 12860493 [PubMed - indexed for MEDLINE]Related articles

Clinical improvement as reflected in measures of function and health-related quality of life following treatment with leflunomide compared with methotrexate in patients with rheumatoid arthritis: sensitivity and relative efficiency to detect a treatment effect in a twelve-month, placebo-controlled trial. Leflunomide Rheumatoid Arthritis Investigators Group.

Tugwell P, Wells G, Strand V, Maetzel A, Bombardier C, Crawford B, Dorrier C, Thompson A.

Arthritis Rheum. 2000 Mar;43(3):506-14. Erratum in: Arthritis Rheum 2000 Jun;43(6):1345. PMID: 10728742 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis.

Weinblatt ME, Kremer JM, Coblyn JS, Maier AL, Helfgott SM, Morrell M, Byrne VM, Kaymakcian MV, Strand V.

Arthritis Rheum. 1999 Jul;42(7):1322-8.PMID: 10403258 [PubMed - indexed for MEDLINE]Related articlesFree article

Leflunomide: a review of its use in active rheumatoid arthritis.

Prakash A, Jarvis B.

Drugs. 1999 Dec;58(6):1137-64. Review.PMID: 10651393 [PubMed - indexed for MEDLINE]Related articles

Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial.

Kremer JM, Genant HK, Moreland LW, Russell AS, Emery P, Abud-Mendoza C, Szechinski J, Li T, Ge Z, Becker JC, Westhovens R.

Ann Intern Med. 2006 Jun 20;144(12):865-76.PMID: 16785475 [PubMed - indexed for MEDLINE]Related articlesFree article

Golimumab, a human anti-tumor necrosis factor alpha monoclonal antibody, injected subcutaneously every four weeks in methotrexate-naive patients with active rheumatoid arthritis: twenty-four-week results of a phase III, multicenter, randomized, double-blind, placebo-controlled study of golimumab before methotrexate as first-line therapy for early-onset rheumatoid arthritis.

Emery P, Fleischmann RM, Moreland LW, Hsia EC, Strusberg I, Durez P, Nash P, Amante EJ, Churchill M, Park W, Pons-Estel BA, Doyle MK, Visvanathan S, Xu W, Rahman MU.

Arthritis Rheum. 2009 Aug;60(8):2272-83.PMID: 19644849 [PubMed - indexed for MEDLINE]Related articles

Efficacy of tacrolimus in rheumatoid arthritis patients who have been treated unsuccessfully with methotrexate: a six-month, double-blind, randomized, dose-ranging study.

Furst DE, Saag K, Fleischmann MR, Sherrer Y, Block JA, Schnitzer T, Rutstein J, Baldassare A, Kaine J, Calabrese L, Dietz F, Sack M, Senter RG, Wiesenhutter C, Schiff M, Stein CM, Satoi Y, Matsumoto A, Caldwell J, Harris RE, Moreland LW, Hurd E, Yocum D, Stamler DA.

Arthritis Rheum. 2002 Aug;46(8):2020-8.PMID: 12209503 [PubMed - indexed for MEDLINE]Related articlesFree article

A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate.

Weinblatt ME, Kremer JM, Bankhurst AD, Bulpitt KJ, Fleischmann RM, Fox RI, Jackson CG, Lange M, Burge DJ.

N Engl J Med. 1999 Jan 28;340(4):253-9.PMID: 9920948 [PubMed - indexed for MEDLINE]Related articlesFree article

Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks.

Cohen SB, Emery P, Greenwald MW, Dougados M, Furie RA, Genovese MC, Keystone EC, Loveless JE, Burmester GR, Cravets MW, Hessey EW, Shaw T, Totoritis MC; REFLEX Trial Group.

Arthritis Rheum. 2006 Sep;54(9):2793-806.PMID: 16947627 [PubMed - indexed for MEDLINE]Related articlesFree article

Dose escalation of parenteral methotrexate in active rheumatoid arthritis that has been unresponsive to conventional doses of methotrexate: a randomized, controlled trial.

Lambert CM, Sandhu S, Lochhead A, Hurst NP, McRorie E, Dhillon V.

Arthritis Rheum. 2004 Feb;50(2):364-71.PMID: 14872477 [PubMed - indexed for MEDLINE]Related articlesFree article

Combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis.

Lee SS, Park YW, Park JJ, Kang YM, Nam EJ, Kim SI, Lee JH, Yoo WH, Lee SI.

Scand J Rheumatol. 2009 Jan-Feb;38(1):11-4.PMID: 19191187 [PubMed - indexed for MEDLINE]Related articles

The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial.

Emery P, Fleischmann R, Filipowicz-Sosnowska A, Schechtman J, Szczepanski L, Kavanaugh A, Racewicz AJ, van Vollenhoven RF, Li NF, Agarwal S, Hessey EW, Shaw TM; DANCER Study Group.

Arthritis Rheum. 2006 May;54(5):1390-400.PMID: 16649186 [PubMed - indexed for MEDLINE]Related articlesFree article

A 48-week, randomized, double-blind, double-observer, placebo-controlled multicenter trial of combination methotrexate and intramuscular gold therapy in rheumatoid arthritis: results of the METGO study.

Lehman AJ, Esdaile JM, Klinkhoff AV, Grant E, Fitzgerald A, Canvin J; METGO Study Group.

Arthritis Rheum. 2005 May;52(5):1360-70.PMID: 15880810 [PubMed - indexed for MEDLINE]Related articlesFree article